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Protein

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Gene

Pde11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity).By similarity1 Publication

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Activity regulationi

Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei664Proton donorBy similarity1
Metal bindingi668Divalent metal cation 1PROSITE-ProRule annotation1
Metal bindingi704Divalent metal cation 1PROSITE-ProRule annotation1
Metal bindingi705Divalent metal cation 1PROSITE-ProRule annotation1
Metal bindingi705Divalent metal cation 2PROSITE-ProRule annotation1
Metal bindingi816Divalent metal cation 1PROSITE-ProRule annotation1
Binding sitei869cAMP or cGMPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Hydrolase
LigandcAMP, cGMP, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418457 cGMP effects
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC:3.1.4.35, EC:3.1.4.53)
Alternative name(s):
cAMP and cGMP phosphodiesterase 11A
Gene namesi
Name:Pde11a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3036251 Pde11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mice live well and have no impaired fertility. They do however display reduced sperm concentration, rate of forward progression and percentage of live spermatozoa. Pre-ejaculated sperm display increased premature/spontaneous capacitance.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470411 – 933Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AAdd BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei239PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP0C1Q2
PaxDbiP0C1Q2
PRIDEiP0C1Q2

PTM databases

iPTMnetiP0C1Q2
PhosphoSitePlusiP0C1Q2

Expressioni

Tissue specificityi

Expressed in testis and developing spermatoza.1 Publication

Gene expression databases

BgeeiENSMUSG00000075270 Expressed in 20 organ(s), highest expression level in central nervous system
CleanExiMM_PDE11A
ExpressionAtlasiP0C1Q2 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097572

Structurei

3D structure databases

ProteinModelPortaliP0C1Q2
SMRiP0C1Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 370GAF 1Add BLAST154
Domaini402 – 558GAF 2Add BLAST157
Domaini588 – 912PDEasePROSITE-ProRule annotationAdd BLAST325

Domaini

The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000119066
HOGENOMiHOG000007068
HOVERGENiHBG101207
InParanoidiP0C1Q2
KOiK13298
OMAiKNHRDVF
OrthoDBiEOG091G04JU
PhylomeDBiP0C1Q2
TreeFamiTF316499

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.450.40, 2 hits
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 2 hits
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 2 hits
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P0C1Q2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASRLDFGE VETFLDRHPE LFEDYLMRKG KQELVDKWLQ RHTSGQGASS
60 70 80 90 100
LRPALAGASS LAQSNAKGSP GIGGGAGPQG SAHSHPTPGG GESAGVPLSP
110 120 130 140 150
SWASGSRGDG SLQRRASQKE LRKSFARSKA IHVNRTYDEQ VTSRAQEPLS
160 170 180 190 200
SVRRRALLRK ASSLPPTTAH ILSALLESRV NLPQYPPTAI DYKCHLKKHN
210 220 230 240 250
ERQFFLELVK DISNDLDLTS LSYKILIFVC LMVDADRCSL FLVEGAAAGK
260 270 280 290 300
KTLVSKFFDV HAGTPLLPCS STENSNEVQV PWGKGIIGYV GEHGETVNIP
310 320 330 340 350
DAYQDRRFND EIDKLTGYKT KSLLCMPIRN SDGEIIGVAQ AINKVPEGAP
360 370 380 390 400
FTEDDEKVMQ MYLPFCGIAI SNAQLFAASR KEYERSRALL EVVNDLFEEQ
410 420 430 440 450
TDLEKIVKKI MHRAQTLLKC ERCSVLLLED IESPVVKFTK SFELMSPKCS
460 470 480 490 500
ADAENSFKES VEKSSYSDWL INNSIAELVA STGLPVNVSD AYQDPRFDAE
510 520 530 540 550
ADQISGFHIR SVLCVPIWNS NHQIIGVAQV LNRLDGKPFD DADQRLFEAF
560 570 580 590 600
VIFCGLGINN TIMYDQVKKS WAKQSVALDV LSYHATCSKA EVDKFKAANI
610 620 630 640 650
PLVSELAIDD IHFDDFSLDV DAMITAALRM FMELGMVQKF KIDYETLCRW
660 670 680 690 700
LLTVRKNYRM VLYHNWRHAF NVCQLMFAML TTAGFQEILT EVEILAVIVG
710 720 730 740 750
CLCHDLDHRG TNNAFQAKSD SALAQLYGTS ATLEHHHFNH AVMILQSEGH
760 770 780 790 800
NIFANLSSKE YSDLMQLLKQ SILATDLTLY FERRTEFFEL VRKGDYDWSI
810 820 830 840 850
TSHRDVFRSM LMTACDLGAV TKPWEISRQV AELVTSEFFE QGDRERSELK
860 870 880 890 900
LTPSAIFDRN RKDELPRLQL EWIDSICMPL YQALVKVNAK LKPMLDSVAA
910 920 930
NRRKWEELHQ KRLQVSAASP DPASPMVAGE DRL
Length:933
Mass (Da):104,563
Last modified:July 25, 2006 - v1
Checksum:i07B7CA1E4F905755
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SXR7F6SXR7_MOUSE
Phosphodiesterase
Pde11a
444Annotation score:
F7AAG1F7AAG1_MOUSE
Dual 3',5'-cyclic-AMP and -GMP phos...
Pde11a
72Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772341, AL845373, AL929133 Genomic DNA Translation: CAM16587.1
AL845373, AL772341, AL929133 Genomic DNA Translation: CAM17618.1
AL929133, AL772341, AL845373 Genomic DNA Translation: CAM23980.1
AL929589 Genomic DNA No translation available.
CCDSiCCDS38152.1
RefSeqiNP_001074502.1, NM_001081033.1
UniGeneiMm.246613

Genome annotation databases

EnsembliENSMUST00000099992; ENSMUSP00000097572; ENSMUSG00000075270
GeneIDi241489
KEGGimmu:241489
UCSCiuc008kex.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772341, AL845373, AL929133 Genomic DNA Translation: CAM16587.1
AL845373, AL772341, AL929133 Genomic DNA Translation: CAM17618.1
AL929133, AL772341, AL845373 Genomic DNA Translation: CAM23980.1
AL929589 Genomic DNA No translation available.
CCDSiCCDS38152.1
RefSeqiNP_001074502.1, NM_001081033.1
UniGeneiMm.246613

3D structure databases

ProteinModelPortaliP0C1Q2
SMRiP0C1Q2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097572

PTM databases

iPTMnetiP0C1Q2
PhosphoSitePlusiP0C1Q2

Proteomic databases

MaxQBiP0C1Q2
PaxDbiP0C1Q2
PRIDEiP0C1Q2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099992; ENSMUSP00000097572; ENSMUSG00000075270
GeneIDi241489
KEGGimmu:241489
UCSCiuc008kex.1 mouse

Organism-specific databases

CTDi50940
MGIiMGI:3036251 Pde11a

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000119066
HOGENOMiHOG000007068
HOVERGENiHBG101207
InParanoidiP0C1Q2
KOiK13298
OMAiKNHRDVF
OrthoDBiEOG091G04JU
PhylomeDBiP0C1Q2
TreeFamiTF316499

Enzyme and pathway databases

ReactomeiR-MMU-418457 cGMP effects
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:P0C1Q2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075270 Expressed in 20 organ(s), highest expression level in central nervous system
CleanExiMM_PDE11A
ExpressionAtlasiP0C1Q2 baseline and differential

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.450.40, 2 hits
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 2 hits
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 2 hits
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDE11_MOUSE
AccessioniPrimary (citable) accession number: P0C1Q2
Secondary accession number(s): A2AKR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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