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Entry version 67 (29 Sep 2021)
Sequence version 1 (25 Jul 2006)
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Protein

DNA polymerase III PolC-type

Gene

polC

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase III PolC-typeUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
PolIIIUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4910

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002045911 – 1435DNA polymerase III PolC-typeAdd BLAST1435

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P0C1P9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P0C1P9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C1P9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini420 – 576ExonucleaseAdd BLAST157

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-C family. PolC subfamily.UniRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.700, 1 hit
3.30.420.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00356, DNApol_PolC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR024754, DNA_PolC-like_N_II
IPR028112, DNA_PolC-type_N_I
IPR029460, DNAPol_HHH
IPR006054, DnaQ
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR006308, PolC_gram_pos
IPR044923, PolC_middle_finger_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14480, DNA_pol3_a_NI, 1 hit
PF11490, DNA_pol3_a_NII, 1 hit
PF07733, DNA_pol3_alpha, 2 hits
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
PF00929, RNase_T, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00479, EXOIII, 1 hit
SM00481, POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098, SSF53098, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00573, dnaq, 1 hit
TIGR01405, polC_Gram_pos, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0C1P9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEQQKFKVL ADQIKISNQL DAEILNSGEL TRIDVSNKNR TWEFHITLPQ
60 70 80 90 100
FLAHEDYLLF INAIEQEFKD IANVTCRFTV TNGTNQDEHA IKYFGHCIDQ
110 120 130 140 150
TALSPKVKGQ LKQKKLIMSG KVLKVMVSND IERNHFDKAC NGSLIKAFRN
160 170 180 190 200
CGFDIDKIIF ETNDNDQEQN LASLEAHIQE EDEQSARLAT EKLEKMKAEK
210 220 230 240 250
AKQQDNKQSA VDKCQIGKPI QIENIKPIES IIEEEFKVAI EGVIFDINLK
260 270 280 290 300
ELKSGRHIVE IKVTDYTDSL VLKMFTRKNK DDLEHFKALS VGKWVRAQGR
310 320 330 340 350
IEEDTFIRDL VMMMSDIEEI KKATKKDKAE EKRVEFHLHT AMSQMDGIPN
360 370 380 390 400
IGAYVKQAAD WGHPAIAVTD HNVVQAFPDA HAAAEKHGIK MIYGMEGMLV
410 420 430 440 450
DDGVPIAYKP QDVVLKDATY VVFDVETTGL SNQYDKIIEL AAVKVHNGEI
460 470 480 490 500
IDKFERFSNP HERLSETIIN LTHITDDMLV DAPEIEEVLT EFKEWVGDAI
510 520 530 540 550
FVAHNASFDM GFIDTGYERL GFGPSTNGVI DTLELSRTIN TEYGKHGLNF
560 570 580 590 600
LAKKYGVELT QHHRAIYDTE ATAYIFIKMV QQMKELGVLN HNEINKKLSN
610 620 630 640 650
EDAYKRARPS HVTLIVQNQQ GLKNLFKIVS ASLVKYFYRT PRIPRSLLDE
660 670 680 690 700
YREGLLVGTA CDEGELFTAV MQKDQSQVEK IAKYYDFIEI QPPALYQDLI
710 720 730 740 750
DRELIRDTET LHEIYQRLIH AGDTAGIPVI ATGNAHYLFE HDGIARKILI
760 770 780 790 800
ASQPGNPLNR STLPEAHFRT TDEMLNEFHF LGEEKAHEIV VKNTNELADR
810 820 830 840 850
IERVVPIKDE LYTPRMEGAN EEIRELSYAN ARKLYGEDLP QIVIDRLEKE
860 870 880 890 900
LKSIIGNGFA VIYLISQRLV KKSLDDGYLV GSRGSVGSSF VATMTEITEV
910 920 930 940 950
NPLPPHYICP NCKTSEFFND GSVGSGFDLP DKTCETCGAP LIKEGQDIPF
960 970 980 990 1000
EKFLGFKGDK VPDIDLNFSG EYQPNAHNYT KVLFGEDKVF RAGTIGTVAE
1010 1020 1030 1040 1050
KTAFGYVKGY LNDQGIHKRG AEIDRLVKGC TGVKATTGQH PGGIIVVPDY
1060 1070 1080 1090 1100
MDIYDFTPIQ YPADDQNSAW MTTHFDFHSI HDNVLKLDIL GHDDPTMIRM
1110 1120 1130 1140 1150
LQDLSGIDPK TIPVDDKEVM QIFSTPESLG VTEDEILCKT GTFGVPNSDR
1160 1170 1180 1190 1200
IRRQMLEDTK PTTFSELVQI SGLSHGTDVW LGNAQELIKT GICDLSSVIG
1210 1220 1230 1240 1250
CRDDIMVYLM YAGLEPSMAF KIMESVRKGK GLTEEMIETM KENEVPDWYL
1260 1270 1280 1290 1300
DSCLKIKYIF PKAHAAAYVL MAVRIAYFKV HHPLYYYASY FTIRASDFDL
1310 1320 1330 1340 1350
ITMIKDKTSI RNTVKDMYSR YMDLGKKEKD VLTVLEIMNE MAHRGYRMQP
1360 1370 1380 1390 1400
ISLEKSQAFE FIIEGDTLIP PFISVPGLGE NVAKRIVEAR DDGPFLSKED
1410 1420 1430
LNKKAGLYQK IIEYLDELGS LPNLPDKAQL SIFDM
Length:1,435
Mass (Da):162,477
Last modified:July 25, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59CA6C672B56981F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86727 Genomic DNA Translation: BAA13160.1
Z48003 Genomic DNA Translation: CAA88043.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S52267

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86727 Genomic DNA Translation: BAA13160.1
Z48003 Genomic DNA Translation: CAA88043.1
PIRiS52267

3D structure databases

SMRiP0C1P9
ModBaseiSearch...

Chemistry databases

BindingDBiP0C1P9
ChEMBLiCHEMBL4910

Proteomic databases

PRIDEiP0C1P9

Family and domain databases

Gene3Di1.10.150.700, 1 hit
3.30.420.10, 1 hit
HAMAPiMF_00356, DNApol_PolC, 1 hit
InterProiView protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR024754, DNA_PolC-like_N_II
IPR028112, DNA_PolC-type_N_I
IPR029460, DNAPol_HHH
IPR006054, DnaQ
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR006308, PolC_gram_pos
IPR044923, PolC_middle_finger_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PfamiView protein in Pfam
PF14480, DNA_pol3_a_NI, 1 hit
PF11490, DNA_pol3_a_NII, 1 hit
PF07733, DNA_pol3_alpha, 2 hits
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
PF00929, RNase_T, 1 hit
SMARTiView protein in SMART
SM00479, EXOIII, 1 hit
SM00481, POLIIIAc, 1 hit
SUPFAMiSSF53098, SSF53098, 1 hit
TIGRFAMsiTIGR00573, dnaq, 1 hit
TIGR01405, polC_Gram_pos, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPO3_STAAU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C1P9
Secondary accession number(s): P68851
, Q53665, Q57110, Q9F1J9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: September 29, 2021
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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