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Protein

Histone H2B type F-M

Gene

H2BFM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Miscellaneous

In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is the target of monoubiquitination.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B type F-M
Alternative name(s):
Histone H2B.s
Short name:
H2B/s
Gene namesi
Name:H2BFM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101812.12
HGNCiHGNC:27867 H2BFM
neXtProtiNX_P0C1H6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi286436
OpenTargetsiENSG00000101812
PharmGKBiPA142671702

Polymorphism and mutation databases

DMDMi110279004

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002448271 – 154Histone H2B type F-MAdd BLAST154

Proteomic databases

PaxDbiP0C1H6
PeptideAtlasiP0C1H6
PRIDEiP0C1H6
ProteomicsDBi52297

PTM databases

PhosphoSitePlusiP0C1H6

Expressioni

Gene expression databases

BgeeiENSG00000101812
CleanExiHS_H2BFM
ExpressionAtlasiP0C1H6 baseline and differential
GenevisibleiP0C1H6 HS

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130376, 1 interactor
STRINGi9606.ENSP00000347119

Structurei

3D structure databases

ProteinModelPortaliP0C1H6
SMRiP0C1H6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
GeneTreeiENSGT00760000118976
HOGENOMiHOG000112843
HOVERGENiHBG081589
InParanoidiP0C1H6
KOiK11252
OMAiPKEANSM
OrthoDBiEOG091G0WZB

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

P0C1H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAASAMAEA SSETTSEEGQ SIQEPKEANS TKAQKQKRRG CRGSRRRHAN
60 70 80 90 100
RRGDSFGDSF TPYFPRVLKQ VHQGLSLSQE AVSVMDSMIH DILDRIATEA
110 120 130 140 150
GQLAHYTKRV TITSRDIQMA VRLLLPGKMG KLAEAQGTNA ALRTSLCAIW

QQRK
Length:154
Mass (Da):17,001
Last modified:April 16, 2014 - v2
Checksum:i700C131F5F5818B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093522 mRNA No translation available.
Z73497 Genomic DNA No translation available.
CCDSiCCDS55468.1
RefSeqiNP_001157888.1, NM_001164416.1
XP_006724703.1, XM_006724640.2
XP_011529224.1, XM_011530922.2
UniGeneiHs.376474

Genome annotation databases

EnsembliENST00000355016; ENSP00000347119; ENSG00000101812
ENST00000598335; ENSP00000482611; ENSG00000101812
GeneIDi286436
KEGGihsa:286436

Similar proteinsi

Entry informationi

Entry nameiH2BFM_HUMAN
AccessioniPrimary (citable) accession number: P0C1H6
Secondary accession number(s): A6NP82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: April 16, 2014
Last modified: June 20, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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