UniProtKB - P0C1G9 (SOX11_RAT)
Protein
Transcription factor SOX-11
Gene
Sox11
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcription factor that acts as a transcriptional activator (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 49 – 117 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cardiac ventricle formation Source: UniProtKB
- cell differentiation Source: GO_Central
- cell population proliferation Source: RGD
- closure of optic fissure Source: UniProtKB
- cornea development in camera-type eye Source: UniProtKB
- embryonic digestive tract morphogenesis Source: UniProtKB
- embryonic skeletal system morphogenesis Source: UniProtKB
- eyelid development in camera-type eye Source: UniProtKB
- glial cell development Source: UniProtKB
- glial cell proliferation Source: UniProtKB
- hard palate development Source: UniProtKB
- kidney development Source: RGD
- lens morphogenesis in camera-type eye Source: UniProtKB
- limb bud formation Source: UniProtKB
- lung morphogenesis Source: UniProtKB
- negative regulation of cell death Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- negative regulation of glial cell proliferation Source: UniProtKB
- negative regulation of lymphocyte proliferation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of transcription regulatory region DNA binding Source: UniProtKB
- neural crest cell development Source: UniProtKB
- neural tube formation Source: UniProtKB
- neuroepithelial cell differentiation Source: UniProtKB
- neuron differentiation Source: RGD
- noradrenergic neuron differentiation Source: UniProtKB
- oligodendrocyte development Source: RGD
- outflow tract morphogenesis Source: UniProtKB
- positive regulation of BMP signaling pathway Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of hippo signaling Source: UniProtKB
- positive regulation of hormone secretion Source: UniProtKB
- positive regulation of lens epithelial cell proliferation Source: UniProtKB
- positive regulation of neurogenesis Source: UniProtKB
- positive regulation of neuron differentiation Source: UniProtKB
- positive regulation of ossification Source: UniProtKB
- positive regulation of osteoblast differentiation Source: UniProtKB
- positive regulation of stem cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription, DNA-templated Source: GO_Central
- regulation of transforming growth factor beta receptor signaling pathway Source: RGD
- signal transduction involved in cell cycle checkpoint Source: RGD
- skeletal muscle cell differentiation Source: RGD
- skeletal system development Source: UniProtKB
- soft palate development Source: UniProtKB
- somite development Source: UniProtKB
- spinal cord development Source: UniProtKB
- sympathetic nervous system development Source: UniProtKB
- ventricular septum morphogenesis Source: UniProtKB
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor SOX-11 |
Gene namesi | Name:Sox11 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69351, Sox11 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationBy similarity
Nucleus
- nuclear chromatin Source: GO_Central
- nucleoplasm Source: Ensembl
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000244267 | 1 – 395 | Transcription factor SOX-11Add BLAST | 395 |
Proteomic databases
PaxDbi | P0C1G9 |
PRIDEi | P0C1G9 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000030034, Expressed in brain and 15 other tissues |
Genevisiblei | P0C1G9, RN |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 363 – 395 | Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2By similarityAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 188 – 214 | Asp/Glu-rich (highly acidic)Add BLAST | 27 | |
Compositional biasi | 297 – 308 | Poly-SerAdd BLAST | 12 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000161652 |
HOGENOMi | CLU_043342_0_0_1 |
InParanoidi | P0C1G9 |
OMAi | VKCVFMD |
OrthoDBi | 1186233at2759 |
PhylomeDBi | P0C1G9 |
TreeFami | TF351735 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR029551, SOX-11 IPR017386, SOX-12/11/4 |
PANTHERi | PTHR10270:SF113, PTHR10270:SF113, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
PIRSFi | PIRSF038098, SOX-12/11/4a, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C1G9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK
60 70 80 90 100
RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR
110 120 130 140 150
EAERLRLKHM ADYPDYKYRP RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG
160 170 180 190 200
PGKKCAKLKA PAGKAGAGKA AQPGDCGAGK AAKCVFLDDD DEEDDEDDEL
210 220 230 240 250
QLRPKPDADD DDDEPAHSHL LPPPAQQQPP QLLRRYSVAK VPASPTLSSA
260 270 280 290 300
AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS
310 320 330 340 350
SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD
360 370 380 390
KDLDSFSEGS LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ004858 mRNA Translation: CAA06166.1 |
RefSeqi | NP_445801.1, NM_053349.1 |
Genome annotation databases
Ensembli | ENSRNOT00000045963; ENSRNOP00000040127; ENSRNOG00000030034 |
GeneIDi | 84046 |
KEGGi | rno:84046 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ004858 mRNA Translation: CAA06166.1 |
RefSeqi | NP_445801.1, NM_053349.1 |
3D structure databases
SMRi | P0C1G9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000040127 |
Proteomic databases
PaxDbi | P0C1G9 |
PRIDEi | P0C1G9 |
Genome annotation databases
Ensembli | ENSRNOT00000045963; ENSRNOP00000040127; ENSRNOG00000030034 |
GeneIDi | 84046 |
KEGGi | rno:84046 |
Organism-specific databases
CTDi | 6664 |
RGDi | 69351, Sox11 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000161652 |
HOGENOMi | CLU_043342_0_0_1 |
InParanoidi | P0C1G9 |
OMAi | VKCVFMD |
OrthoDBi | 1186233at2759 |
PhylomeDBi | P0C1G9 |
TreeFami | TF351735 |
Miscellaneous databases
PROi | PR:P0C1G9 |
Gene expression databases
Bgeei | ENSRNOG00000030034, Expressed in brain and 15 other tissues |
Genevisiblei | P0C1G9, RN |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR029551, SOX-11 IPR017386, SOX-12/11/4 |
PANTHERi | PTHR10270:SF113, PTHR10270:SF113, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
PIRSFi | PIRSF038098, SOX-12/11/4a, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOX11_RAT | |
Accessioni | P0C1G9Primary (citable) accession number: P0C1G9 Secondary accession number(s): O35178, O89036, Q04889 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |