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Protein

Dortoxin

Gene
N/A
Organism
Parabuthus transvaalicus (South African fattail scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to sodium channels (Nav) and affects the channel activation process (By similarity). In mice, causes hyperactivity that persists until death.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Dortoxin
Alternative name(s):
Dorsotoxin
OrganismiParabuthus transvaalicus (South African fattail scorpion)
Taxonomic identifieri170972 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeParabuthus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002336301 – 58DortoxinAdd BLAST58

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ 41PROSITE-ProRule annotation
Disulfide bondi27 ↔ 46PROSITE-ProRule annotation
Disulfide bondi31 ↔ 48PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP0C1B7
SMRiP0C1B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 58LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit

Sequencei

Sequence statusi: Complete.

P0C1B7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ADVPGNYPLD KDGNTYTCLK LGENKDCQKV CKLHGVQYGY CYAFECWCKE

YLDDKDSV
Length:58
Mass (Da):6,648
Last modified:May 2, 2006 - v1
Checksum:i732B4ED9FC645260
GO

Mass spectrometryi

Molecular mass is 6641.4 Da from positions 1 - 58. Determined by ESI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C1B7
SMRiP0C1B7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDORT_PARTR
AccessioniPrimary (citable) accession number: P0C1B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: July 18, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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