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Protein

Altitoxin

Gene
N/A
Organism
Parabuthus transvaalicus (South African fattail scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). In mice, causes akinesia, depression and death.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Altitoxin
OrganismiParabuthus transvaalicus (South African fattail scorpion)
Taxonomic identifieri170972 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeParabuthus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002336281 – 58AltitoxinAdd BLAST58

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ 41PROSITE-ProRule annotation
Disulfide bondi27 ↔ 46PROSITE-ProRule annotation
Disulfide bondi31 ↔ 48PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP0C1B5
SMRiP0C1B5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 58LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit

Sequencei

Sequence statusi: Complete.

P0C1B5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ADVPGNYPLD KDGNTYTCLE LGENKDCQKV CKLHGVQYGY CYAFFCWCKE

LDDKDVSV
Length:58
Mass (Da):6,603
Last modified:October 17, 2006 - v2
Checksum:iE4FD56B065F7985E
GO

Mass spectrometryi

Molecular mass is 6598.2 Da from positions 1 - 58. Determined by ESI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C1B5
SMRiP0C1B5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALTI_PARTR
AccessioniPrimary (citable) accession number: P0C1B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 40 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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