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Protein

Platelet glycoprotein VI

Gene

Gp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Collagen receptor involved in collagen-induced platelet adhesion and activation (PubMed:16139873, PubMed:24368846). Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.4 Publications

GO - Molecular functioni

  • collagen binding Source: MGI
  • collagen receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-75892 Platelet Adhesion to exposed collagen

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein VICurated
Short name:
GPVICurated
Alternative name(s):
Glycoprotein 5
Gene namesi
Name:Gp6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1889810 Gp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 265ExtracellularSequence analysisAdd BLAST244
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 313CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice deficient in Gp6 show a complete protection against arterial thrombosis and induced pulmonary thromboembolism, without significant prolongation of bleeding time (PubMed:16139873). Mutant mice deficient in Gp6 and P3h2 are born at the expected Mendelian rate and have no visible phenotype (PubMed:24368846).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000023238422 – 313Platelet glycoprotein VIAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 89By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi135 ↔ 181By similarity
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP0C191
PaxDbiP0C191
PRIDEiP0C191

Expressioni

Tissue specificityi

Megakaryocytes and platelets.1 Publication

Developmental stagei

Expressed at embryonic day 13.5, 14.5 and 16.5. Expression decreases in intensity at day 18.5 and in 1.5 day-old newborn.1 Publication

Gene expression databases

BgeeiENSMUSG00000078810 Expressed in 22 organ(s), highest expression level in blood
ExpressionAtlasiP0C191 baseline and differential
GenevisibleiP0C191 MM

Interactioni

Subunit structurei

Associated with Fc receptor gamma chain. The GPVI:FcRgamma complex is associated with the Src kinase family FYN and LYN (By similarity). Interacts with COL1A1, but not with COL4A4 (PubMed:24368846).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104231

Structurei

3D structure databases

ProteinModelPortaliP0C191
SMRiP0C191
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 105Ig-like C2-type 1Add BLAST79
Domaini115 – 197Ig-like C2-type 2Add BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi183 – 188Poly-Ser6

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHKK Eukaryota
ENOG411142H LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiP0C191
KOiK06264
OrthoDBiEOG091G0HU0
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0C191-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPASPTFFC IGLCVLQVIQ TQSGPLPKPS LQAQPSSLVP LGQSVILRCQ
60 70 80 90 100
GPPDVDLYRL EKLKPEKYED QDFLFIPTME RSNAGRYRCS YQNGSHWSLP
110 120 130 140 150
SDQLELIATG VYAKPSLSAH PSSAVPQGRD VTLKCQSPYS FDEFVLYKEG
160 170 180 190 200
DTGSYKRPEK WYRANFPIIT VTAAHSGTYR CYSFSSSSPY LWSAPSDPLV
210 220 230 240 250
LVVTGLSATP SQVPTEESFP VTESSRRPSI LPTNKISTTE KPMNITASPE
260 270 280 290 300
GLSPPFGFAH QHYAKGNLVR ICLGATIIII LLGLLAEDWH SRKKCLQHRM
310
RALQRPLPPL PLA
Length:313
Mass (Da):34,595
Last modified:July 27, 2011 - v2
Checksum:i34D810EAE120C535
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T8Q7A0A140T8Q7_MOUSE
Platelet glycoprotein VI
Gp6
296Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti256F → I no nucleotide entry (PubMed:10961879).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137969 Genomic DNA No translation available.
CCDSiCCDS51972.1
RefSeqiNP_001156486.1, NM_001163014.1
UniGeneiMm.248662

Genome annotation databases

EnsembliENSMUST00000206928; ENSMUSP00000145740; ENSMUSG00000078810
GeneIDi243816
KEGGimmu:243816
UCSCiuc009exk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137969 Genomic DNA No translation available.
CCDSiCCDS51972.1
RefSeqiNP_001156486.1, NM_001163014.1
UniGeneiMm.248662

3D structure databases

ProteinModelPortaliP0C191
SMRiP0C191
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104231

Proteomic databases

MaxQBiP0C191
PaxDbiP0C191
PRIDEiP0C191

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000206928; ENSMUSP00000145740; ENSMUSG00000078810
GeneIDi243816
KEGGimmu:243816
UCSCiuc009exk.2 mouse

Organism-specific databases

CTDi51206
MGIiMGI:1889810 Gp6

Phylogenomic databases

eggNOGiENOG410IHKK Eukaryota
ENOG411142H LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiP0C191
KOiK06264
OrthoDBiEOG091G0HU0
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-75892 Platelet Adhesion to exposed collagen

Miscellaneous databases

PROiPR:P0C191
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078810 Expressed in 22 organ(s), highest expression level in blood
ExpressionAtlasiP0C191 baseline and differential
GenevisibleiP0C191 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGPVI_MOUSE
AccessioniPrimary (citable) accession number: P0C191
Secondary accession number(s): E9QPN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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