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Protein

Potassium channel toxin epsilon-KTx 1.2

Gene
N/A
Organism
Tityus serrulatus (Brazilian scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potassium channel blocker. At 3 µM, this toxin blocks voltage-gated potassium channels rKv1.2/KCNA2 (5%), hKv1.3/KCNA3 (10%),rKv1.4/KCNA4 (20%), Kv11/hERG (24%), and Shaker-IR (27%).1 Publication

Miscellaneous

Does not block voltage-gated potassium channel rKv1.1/KCNA1, rKv1.5/KCNA5, and rKv1.6/KCNA6.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin epsilon-KTx 1.21 Publication
Alternative name(s):
Ts121 Publication
TsPep21 Publication
OrganismiTityus serrulatus (Brazilian scorpion)
Taxonomic identifieri6887 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
PeptideiPRO_000022782027 – 55Potassium channel toxin epsilon-KTx 1.2Add BLAST29
PropeptideiPRO_000022782157 – 68Add BLAST12

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 38By similarity
Disulfide bondi33 ↔ 54By similarity
Disulfide bondi37 ↔ 47By similarity
Disulfide bondi42 ↔ 52By similarity
Modified residuei55Tyrosine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP0C175
SMRiP0C175
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
Is completely devoid of the classical secondary structure elements (alpha-helix and/or beta-strand).By similarity

Sequence similaritiesi

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C175-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFSCGFLLI FLVLSAMIAT FSEVEATVKC GGCNRKCCAG GCRSGKCING
60
KCQCYGRSDL NEEFENYQ
Length:68
Mass (Da):7,435
Last modified:March 21, 2006 - v1
Checksum:iFEF23172A7BC6A3C
GO

Mass spectrometryi

Molecular mass is 2993.71 Da from positions 27 - 55. Determined by MALDI. 1 Publication
Molecular mass is 2991.3 Da from positions 27 - 55. Determined by MALDI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C175
SMRiP0C175
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKEX12_TITSE
AccessioniPrimary (citable) accession number: P0C175
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: April 25, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
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