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UniProtKB - P0C0S8 (H2A1_HUMAN)

Protein

Histone H2A type 1

Gene

HIST1H2AG

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • enzyme binding Source: UniProtKB
  • protein heterodimerization activity Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5689901 Metalloprotease DUBs
SIGNORiP0C0S8

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A type 1
Short name:
H2A.1
Alternative name(s):
Histone H2A/ptl
Gene namesi
Name:HIST1H2AG
Synonyms:H2AFP
AND
Name:HIST1H2AI
Synonyms:H2AFC
AND
Name:HIST1H2AK
Synonyms:H2AFD
AND
Name:HIST1H2AL
Synonyms:H2AFI
AND
Name:HIST1H2AM
Synonyms:H2AFN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000196747.4
HostDB:ENSG00000196787.3
HostDB:ENSG00000275221.1
HostDB:ENSG00000276903.1
HostDB:ENSG00000278677.1
HGNCiHGNC:4737 HIST1H2AG
HGNC:4725 HIST1H2AI
HGNC:4726 HIST1H2AK
HGNC:4730 HIST1H2AL
HGNC:4735 HIST1H2AM
MIMi602787 gene
602788 gene
602793 gene
602796 gene
615012 gene
neXtProtiNX_P0C0S8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2S → A: Blocks the inhibition of transcription by RPS6KA5/MSK1. 1 Publication1

Organism-specific databases

DisGeNETi8332
OpenTargetsiENSG00000196747
ENSG00000196787
ENSG00000275221
ENSG00000276903
ENSG00000278677
PharmGKBiPA29114

Polymorphism and mutation databases

BioMutaiHIST1H2AG
DMDMi83288406

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000552352 – 130Histone H2A type 1Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine3 Publications1
Modified residuei2Phosphoserine; by RPS6KA52 Publications1
Modified residuei4Citrulline; alternate1 Publication1
Modified residuei4Symmetric dimethylarginine; by PRMT5; alternateBy similarity1
Modified residuei6N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei10N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei10N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei10N6-succinyllysine; alternate1 Publication1
Modified residuei14N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate2 Publications
Cross-linki16Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei37N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei37N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei37N6-crotonyllysine; alternate1 Publication1
Modified residuei75N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei76N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei96N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei96N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei96N6-succinyllysine; alternate1 Publication1
Modified residuei105N5-methylglutamine1 Publication1
Modified residuei119N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei119N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei119N6-crotonyllysine; alternate1 Publication1
Modified residuei120N6-crotonyllysine; alternate1 Publication1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate4 Publications
Modified residuei121Phosphothreonine; by DCAF12 Publications1
Modified residuei126N6-crotonyllysine1 Publication1

Post-translational modificationi

Deiminated on Arg-4 in granulocytes upon calcium entry.1 Publication
Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.12 Publications
Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.6 Publications
Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.By similarity
Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).1 Publication
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP0C0S8
MaxQBiP0C0S8
PaxDbiP0C0S8
PeptideAtlasiP0C0S8
PRIDEiP0C0S8
ProteomicsDBi52296
TopDownProteomicsiP0C0S8

PTM databases

iPTMnetiP0C0S8
PhosphoSitePlusiP0C0S8
SwissPalmiP0C0S8

Expressioni

Gene expression databases

BgeeiENSG00000196747 Expressed in 71 organ(s), highest expression level in stomach
CleanExiHS_HIST1H2AG
HS_HIST1H2AI
HS_HIST1H2AK
HS_HIST1H2AL
HS_HIST1H2AM
ExpressionAtlasiP0C0S8 baseline and differential
GenevisibleiP0C0S8 HS

Organism-specific databases

HPAiHPA041189

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi113925, 11 interactors
113926, 12 interactors
113928, 10 interactors
113932, 12 interactors
114459, 53 interactors
DIPiDIP-39638N
IntActiP0C0S8, 29 interactors
MINTiP0C0S8
STRINGi9606.ENSP00000352627

Structurei

3D structure databases

ProteinModelPortaliP0C0S8
SMRiP0C0S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOGENOMiHOG000234652
HOVERGENiHBG009342
InParanoidiP0C0S8
KOiK11251
OrthoDBiEOG091G0XGD
PhylomeDBiP0C0S8
TreeFamiTF300137

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0S8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV 
        60         70         80         90        100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK 
       110        120        130
VTIAQGGVLP NIQAVLLPKK TESHHKAKGK
Length:130
Mass (Da):14,091
Last modified:January 23, 2007 - v2
Checksum:i48DD539793FE8256
GO

Mass spectrometryi

Molecular mass is 13993.9 Da from positions 2 - 130. Determined by ESI. Monoisotopic with N-acetylserine.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83742 Genomic DNA Translation: CAB06037.1
Z83739 Genomic DNA Translation: CAB06034.1
X83549 Genomic DNA Translation: CAA58539.1
X57138 Genomic DNA Translation: CAA40417.1
L19778 mRNA Translation: AAC24466.1
AY131987 Genomic DNA Translation: AAN59968.1
AY131989 Genomic DNA Translation: AAN59970.1
AY131991 Genomic DNA Translation: AAN59972.1
AY131992 Genomic DNA Translation: AAN59973.1
AY131993 Genomic DNA Translation: AAN59974.1
Z98744 Genomic DNA No translation available.
AL009179 Genomic DNA No translation available.
AL021807 Genomic DNA No translation available.
BC016677 mRNA Translation: AAH16677.1
BC069306 mRNA Translation: AAH69306.1
BC104199 mRNA Translation: AAI04200.1
BC104198 mRNA Translation: AAI04199.1
BC105129 mRNA Translation: AAI05130.1
BC112072 mRNA Translation: AAI12073.1
BC112254 mRNA Translation: AAI12255.1
BC112256 mRNA Translation: AAI12257.1
CCDSiCCDS4619.1
CCDS4626.1
CCDS4632.1
CCDS4634.1
CCDS4639.1
PIRiB56624 HSHUA1
RefSeqiNP_003500.1, NM_003509.2
NP_003501.1, NM_003510.2
NP_003502.1, NM_003511.2
NP_003505.1, NM_003514.2
NP_066408.1, NM_021064.4
UniGeneiHs.134999
Hs.233568
Hs.51011
Hs.534035
Hs.734717

Genome annotation databases

EnsembliENST00000358739; ENSP00000351589; ENSG00000196747
ENST00000359193; ENSP00000352119; ENSG00000196787
ENST00000359611; ENSP00000352627; ENSG00000278677
ENST00000613174; ENSP00000482538; ENSG00000276903
ENST00000618958; ENSP00000482431; ENSG00000275221
GeneIDi8329
8330
8332
8336
8969
KEGGihsa:8329
hsa:8330
hsa:8332
hsa:8336
hsa:8969
UCSCiuc003niw.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83742 Genomic DNA Translation: CAB06037.1
Z83739 Genomic DNA Translation: CAB06034.1
X83549 Genomic DNA Translation: CAA58539.1
X57138 Genomic DNA Translation: CAA40417.1
L19778 mRNA Translation: AAC24466.1
AY131987 Genomic DNA Translation: AAN59968.1
AY131989 Genomic DNA Translation: AAN59970.1
AY131991 Genomic DNA Translation: AAN59972.1
AY131992 Genomic DNA Translation: AAN59973.1
AY131993 Genomic DNA Translation: AAN59974.1
Z98744 Genomic DNA No translation available.
AL009179 Genomic DNA No translation available.
AL021807 Genomic DNA No translation available.
BC016677 mRNA Translation: AAH16677.1
BC069306 mRNA Translation: AAH69306.1
BC104199 mRNA Translation: AAI04200.1
BC104198 mRNA Translation: AAI04199.1
BC105129 mRNA Translation: AAI05130.1
BC112072 mRNA Translation: AAI12073.1
BC112254 mRNA Translation: AAI12255.1
BC112256 mRNA Translation: AAI12257.1
CCDSiCCDS4619.1
CCDS4626.1
CCDS4632.1
CCDS4634.1
CCDS4639.1
PIRiB56624 HSHUA1
RefSeqiNP_003500.1, NM_003509.2
NP_003501.1, NM_003510.2
NP_003502.1, NM_003511.2
NP_003505.1, NM_003514.2
NP_066408.1, NM_021064.4
UniGeneiHs.134999
Hs.233568
Hs.51011
Hs.534035
Hs.734717

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QYLX-ray1.80E/F/G/H2-13[»]
5KGFelectron microscopy4.54C/G1-130[»]
ProteinModelPortaliP0C0S8
SMRiP0C0S8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113925, 11 interactors
113926, 12 interactors
113928, 10 interactors
113932, 12 interactors
114459, 53 interactors
DIPiDIP-39638N
IntActiP0C0S8, 29 interactors
MINTiP0C0S8
STRINGi9606.ENSP00000352627

PTM databases

iPTMnetiP0C0S8
PhosphoSitePlusiP0C0S8
SwissPalmiP0C0S8

Polymorphism and mutation databases

BioMutaiHIST1H2AG
DMDMi83288406

Proteomic databases

EPDiP0C0S8
MaxQBiP0C0S8
PaxDbiP0C0S8
PeptideAtlasiP0C0S8
PRIDEiP0C0S8
ProteomicsDBi52296
TopDownProteomicsiP0C0S8

Protocols and materials databases

DNASUi8329
8330
8332
8969
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358739; ENSP00000351589; ENSG00000196747
ENST00000359193; ENSP00000352119; ENSG00000196787
ENST00000359611; ENSP00000352627; ENSG00000278677
ENST00000613174; ENSP00000482538; ENSG00000276903
ENST00000618958; ENSP00000482431; ENSG00000275221
GeneIDi8329
8330
8332
8336
8969
KEGGihsa:8329
hsa:8330
hsa:8332
hsa:8336
hsa:8969
UCSCiuc003niw.4 human

Organism-specific databases

CTDi8329
8330
8332
8336
8969
DisGeNETi8332
EuPathDBiHostDB:ENSG00000196747.4
HostDB:ENSG00000196787.3
HostDB:ENSG00000275221.1
HostDB:ENSG00000276903.1
HostDB:ENSG00000278677.1
GeneCardsiHIST1H2AG
HIST1H2AI
HIST1H2AK
HIST1H2AL
HIST1H2AM
H-InvDBiHIX0200889
HGNCiHGNC:4737 HIST1H2AG
HGNC:4725 HIST1H2AI
HGNC:4726 HIST1H2AK
HGNC:4730 HIST1H2AL
HGNC:4735 HIST1H2AM
HPAiHPA041189
MIMi602787 gene
602788 gene
602793 gene
602796 gene
615012 gene
neXtProtiNX_P0C0S8
OpenTargetsiENSG00000196747
ENSG00000196787
ENSG00000275221
ENSG00000276903
ENSG00000278677
PharmGKBiPA29114
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOGENOMiHOG000234652
HOVERGENiHBG009342
InParanoidiP0C0S8
KOiK11251
OrthoDBiEOG091G0XGD
PhylomeDBiP0C0S8
TreeFamiTF300137

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5689901 Metalloprotease DUBs
SIGNORiP0C0S8

Miscellaneous databases

ChiTaRSiHIST1H2AM human
GeneWikiiHIST1H2AG
HIST1H2AI
HIST1H2AK
HIST1H2AL
HIST1H2AM
PROiPR:P0C0S8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196747 Expressed in 71 organ(s), highest expression level in stomach
CleanExiHS_HIST1H2AG
HS_HIST1H2AI
HS_HIST1H2AK
HS_HIST1H2AL
HS_HIST1H2AM
ExpressionAtlasiP0C0S8 baseline and differential
GenevisibleiP0C0S8 HS

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2A1_HUMAN
AccessioniPrimary (citable) accession number: P0C0S8
Secondary accession number(s): P02261, Q2M1R2, Q76PA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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