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UniProtKB - P0C0S8 (H2A1_HUMAN)

Entry version 141 (13 Feb 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H2A type 1

Gene

HIST1H2AG

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: GO_Central
  • enzyme binding Source: UniProtKB
  • protein heterodimerization activity Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5689901 Metalloprotease DUBs

SIGNOR Signaling Network Open Resource

More...SIGNORi		P0C0S8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H2A type 1
Short name:
H2A.1
Alternative name(s):
Histone H2A/ptl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HIST1H2AG
Synonyms:H2AFP
AND
Name:HIST1H2AI
Synonyms:H2AFC
AND
Name:HIST1H2AK
Synonyms:H2AFD
AND
Name:HIST1H2AL
Synonyms:H2AFI
AND
Name:HIST1H2AM
Synonyms:H2AFN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000196747.4
HostDB:ENSG00000196787.3
HostDB:ENSG00000275221.1
HostDB:ENSG00000276903.1
HostDB:ENSG00000278677.1

Human Gene Nomenclature Database

More...HGNCi		HGNC:4737 HIST1H2AG
HGNC:4725 HIST1H2AI
HGNC:4726 HIST1H2AK
HGNC:4730 HIST1H2AL
HGNC:4735 HIST1H2AM

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602787 gene
602788 gene
602793 gene
602796 gene
615012 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P0C0S8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2S → A: Blocks the inhibition of transcription by RPS6KA5/MSK1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8332

Open Targets

More...OpenTargetsi		ENSG00000196747
ENSG00000196787
ENSG00000275221
ENSG00000276903
ENSG00000278677

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29114

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HIST1H2AI

Domain mapping of disease mutations (DMDM)

More...DMDMi		83288406

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000552352 – 130Histone H2A type 1Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine3 Publications1
Modified residuei2Phosphoserine; by RPS6KA52 Publications1
Modified residuei4Citrulline; alternate1 Publication1
Modified residuei4Symmetric dimethylarginine; by PRMT5; alternateBy similarity1
Modified residuei6N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei10N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei10N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei10N6-succinyllysine; alternate1 Publication1
Modified residuei14N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate2 Publications
Cross-linki16Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei37N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei37N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei37N6-crotonyllysine; alternate1 Publication1
Modified residuei75N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei76N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei96N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei96N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei96N6-succinyllysine; alternate1 Publication1
Modified residuei105N5-methylglutamine1 Publication1
Modified residuei119N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei119N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei119N6-crotonyllysine; alternate1 Publication1
Modified residuei120N6-crotonyllysine; alternate1 Publication1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate4 Publications
Modified residuei121Phosphothreonine; by DCAF12 Publications1
Modified residuei126N6-crotonyllysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Deiminated on Arg-4 in granulocytes upon calcium entry.1 Publication
Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.12 Publications
Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.6 Publications
Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.By similarity
Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).1 Publication
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P0C0S8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0C0S8

MaxQB - The MaxQuant DataBase

More...MaxQBi		P0C0S8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0C0S8

PeptideAtlas

More...PeptideAtlasi		P0C0S8

PRoteomics IDEntifications database

More...PRIDEi		P0C0S8

ProteomicsDB human proteome resource

More...ProteomicsDBi		52296

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P0C0S8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P0C0S8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P0C0S8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P0C0S8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196747 Expressed in 71 organ(s), highest expression level in stomach

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P0C0S8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA041189

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113925, 12 interactors
113926, 12 interactors
113928, 10 interactors
113932, 12 interactors
114459, 54 interactors

Database of interacting proteins

More...DIPi		DIP-39638N

Protein interaction database and analysis system

More...IntActi		P0C0S8, 30 interactors

Molecular INTeraction database

More...MINTi		P0C0S8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352627

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QYLX-ray1.80E/F/G/H2-13[»]
5KGFelectron microscopy4.54C/G1-130[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P0C0S8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0C0S8

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1756 Eukaryota
COG5262 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153125

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234652

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG009342

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0C0S8

KEGG Orthology (KO)

More...KOi		K11251

Database of Orthologous Groups

More...OrthoDBi		1504122at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0C0S8

TreeFam database of animal gene trees

More...TreeFami		TF300137

Family and domain databases

Conserved Domains Database

More...CDDi		cd00074 H2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00620 HISTONEH2A

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00414 H2A, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47113 SSF47113, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0S8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV 
        60         70         80         90        100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK 
       110        120        130
VTIAQGGVLP NIQAVLLPKK TESHHKAKGK
Length:130
Mass (Da):14,091
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48DD539793FE8256
GO

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 13993.9 Da from positions 2 - 130. Determined by ESI. Monoisotopic with N-acetylserine.1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z83742 Genomic DNA Translation: CAB06037.1
Z83739 Genomic DNA Translation: CAB06034.1
X83549 Genomic DNA Translation: CAA58539.1
X57138 Genomic DNA Translation: CAA40417.1
L19778 mRNA Translation: AAC24466.1
AY131987 Genomic DNA Translation: AAN59968.1
AY131989 Genomic DNA Translation: AAN59970.1
AY131991 Genomic DNA Translation: AAN59972.1
AY131992 Genomic DNA Translation: AAN59973.1
AY131993 Genomic DNA Translation: AAN59974.1
Z98744 Genomic DNA No translation available.
AL009179 Genomic DNA No translation available.
AL021807 Genomic DNA No translation available.
BC016677 mRNA Translation: AAH16677.1
BC069306 mRNA Translation: AAH69306.1
BC104199 mRNA Translation: AAI04200.1
BC104198 mRNA Translation: AAI04199.1
BC105129 mRNA Translation: AAI05130.1
BC112072 mRNA Translation: AAI12073.1
BC112254 mRNA Translation: AAI12255.1
BC112256 mRNA Translation: AAI12257.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4619.1
CCDS4626.1
CCDS4632.1
CCDS4634.1
CCDS4639.1

Protein sequence database of the Protein Information Resource

More...PIRi		B56624 HSHUA1

NCBI Reference Sequences

More...RefSeqi		NP_003500.1, NM_003509.2
NP_003501.1, NM_003510.2
NP_003502.1, NM_003511.2
NP_003505.1, NM_003514.2
NP_066408.1, NM_021064.4

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.134999
Hs.233568
Hs.51011
Hs.534035
Hs.734717

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000358739; ENSP00000351589; ENSG00000196747
ENST00000359193; ENSP00000352119; ENSG00000196787
ENST00000359611; ENSP00000352627; ENSG00000278677
ENST00000613174; ENSP00000482538; ENSG00000276903
ENST00000618958; ENSP00000482431; ENSG00000275221

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8329
8330
8332
8336
8969

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8329
hsa:8330
hsa:8332
hsa:8336
hsa:8969

UCSC genome browser

More...UCSCi		uc003niw.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83742 Genomic DNA Translation: CAB06037.1
Z83739 Genomic DNA Translation: CAB06034.1
X83549 Genomic DNA Translation: CAA58539.1
X57138 Genomic DNA Translation: CAA40417.1
L19778 mRNA Translation: AAC24466.1
AY131987 Genomic DNA Translation: AAN59968.1
AY131989 Genomic DNA Translation: AAN59970.1
AY131991 Genomic DNA Translation: AAN59972.1
AY131992 Genomic DNA Translation: AAN59973.1
AY131993 Genomic DNA Translation: AAN59974.1
Z98744 Genomic DNA No translation available.
AL009179 Genomic DNA No translation available.
AL021807 Genomic DNA No translation available.
BC016677 mRNA Translation: AAH16677.1
BC069306 mRNA Translation: AAH69306.1
BC104199 mRNA Translation: AAI04200.1
BC104198 mRNA Translation: AAI04199.1
BC105129 mRNA Translation: AAI05130.1
BC112072 mRNA Translation: AAI12073.1
BC112254 mRNA Translation: AAI12255.1
BC112256 mRNA Translation: AAI12257.1
CCDSiCCDS4619.1
CCDS4626.1
CCDS4632.1
CCDS4634.1
CCDS4639.1
PIRiB56624 HSHUA1
RefSeqiNP_003500.1, NM_003509.2
NP_003501.1, NM_003510.2
NP_003502.1, NM_003511.2
NP_003505.1, NM_003514.2
NP_066408.1, NM_021064.4
UniGeneiHs.134999
Hs.233568
Hs.51011
Hs.534035
Hs.734717

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QYLX-ray1.80E/F/G/H2-13[»]
5KGFelectron microscopy4.54C/G1-130[»]
ProteinModelPortaliP0C0S8
SMRiP0C0S8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113925, 12 interactors
113926, 12 interactors
113928, 10 interactors
113932, 12 interactors
114459, 54 interactors
DIPiDIP-39638N
IntActiP0C0S8, 30 interactors
MINTiP0C0S8
STRINGi9606.ENSP00000352627

PTM databases

iPTMnetiP0C0S8
PhosphoSitePlusiP0C0S8
SwissPalmiP0C0S8

Polymorphism and mutation databases

BioMutaiHIST1H2AI
DMDMi83288406

Proteomic databases

EPDiP0C0S8
jPOSTiP0C0S8
MaxQBiP0C0S8
PaxDbiP0C0S8
PeptideAtlasiP0C0S8
PRIDEiP0C0S8
ProteomicsDBi52296
TopDownProteomicsiP0C0S8

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		8329
8330
8332
8969
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358739; ENSP00000351589; ENSG00000196747
ENST00000359193; ENSP00000352119; ENSG00000196787
ENST00000359611; ENSP00000352627; ENSG00000278677
ENST00000613174; ENSP00000482538; ENSG00000276903
ENST00000618958; ENSP00000482431; ENSG00000275221
GeneIDi8329
8330
8332
8336
8969
KEGGihsa:8329
hsa:8330
hsa:8332
hsa:8336
hsa:8969
UCSCiuc003niw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8329
8330
8332
8336
8969
DisGeNETi8332
EuPathDBiHostDB:ENSG00000196747.4
HostDB:ENSG00000196787.3
HostDB:ENSG00000275221.1
HostDB:ENSG00000276903.1
HostDB:ENSG00000278677.1

GeneCards: human genes, protein and diseases

More...GeneCardsi		HIST1H2AG
HIST1H2AI
HIST1H2AK
HIST1H2AL
HIST1H2AM

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0200889
HGNCiHGNC:4737 HIST1H2AG
HGNC:4725 HIST1H2AI
HGNC:4726 HIST1H2AK
HGNC:4730 HIST1H2AL
HGNC:4735 HIST1H2AM
HPAiHPA041189
MIMi602787 gene
602788 gene
602793 gene
602796 gene
615012 gene
neXtProtiNX_P0C0S8
OpenTargetsiENSG00000196747
ENSG00000196787
ENSG00000275221
ENSG00000276903
ENSG00000278677
PharmGKBiPA29114

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00940000153125
HOGENOMiHOG000234652
HOVERGENiHBG009342
InParanoidiP0C0S8
KOiK11251
OrthoDBi1504122at2759
PhylomeDBiP0C0S8
TreeFamiTF300137

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5689901 Metalloprotease DUBs
SIGNORiP0C0S8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HIST1H2AM human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HIST1H2AG
HIST1H2AI
HIST1H2AK
HIST1H2AL
HIST1H2AM

Protein Ontology

More...PROi		PR:P0C0S8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196747 Expressed in 71 organ(s), highest expression level in stomach
GenevisibleiP0C0S8 HS

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C0S8
Secondary accession number(s): P02261, Q2M1R2, Q76PA6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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