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UniProtKB - P0C0S6 (H2AZ_MOUSE)

Entry version 140 (25 May 2022)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Histone H2A.Z

Gene

H2az1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Essential for early development.

3 Publications

Miscellaneous

Down-regulation of H2az1 by RNA interference leads to death at early embryonic stages.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-110330, Recognition and association of DNA glycosylase with site containing an affected purine
R-MMU-110331, Cleavage of the damaged purine
R-MMU-212300, PRC2 methylates histones and DNA
R-MMU-2299718, Condensation of Prophase Chromosomes
R-MMU-2559580, Oxidative Stress Induced Senescence
R-MMU-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586, DNA Damage/Telomere Stress Induced Senescence
R-MMU-427359, SIRT1 negatively regulates rRNA expression
R-MMU-427413, NoRC negatively regulates rRNA expression
R-MMU-5250924, B-WICH complex positively regulates rRNA expression
R-MMU-5578749, Transcriptional regulation by small RNAs
R-MMU-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-68616, Assembly of the ORC complex at the origin of replication
R-MMU-73728, RNA Polymerase I Promoter Opening
R-MMU-73772, RNA Polymerase I Promoter Escape
R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519, Estrogen-dependent gene expression
R-MMU-9670095, Inhibition of DNA recombination at telomere

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H2A.Z
Short name:
H2A/z
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:H2az1Imported
Synonyms:H2afzImported, H2az1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1888388, H2az1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000037894

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCurated
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000552982 – 128Histone H2A.ZAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5N6-acetyllysine; alternate1 Publication1
Modified residuei5N6-methyllysine; alternateBy similarity1
Modified residuei8N6-acetyllysine; alternate1 Publication1
Modified residuei8N6-methyllysine; alternateBy similarity1
Modified residuei12N6-acetyllysine; alternate1 Publication1
Modified residuei12N6-lactoyllysine; alternate1 Publication1
Modified residuei14N6-acetyllysine; alternateBy similarity1
Modified residuei14N6-lactoyllysine; alternateBy similarity1
Modified residuei116N6-lactoyllysine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.By similarity
Acetylated on Lys-5, Lys-8, Lys-12 and Lys-14 by KAT2A; KAT2A is recruited by the XPC complex in absence of DNA damage (By similarity). Acetylated on Lys-5, Lys-8 and Lys-12 during interphase; acetylation disappears at mitosis (PubMed:16204459, PubMed:7217105). Acetylation by the NuA4 histone acetyltransferase complex is required for hematopoietic stem cell maintenance (PubMed:32542325).By similarity3 Publications
Not phosphorylated.1 Publication
Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.By similarity
Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P0C0S6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0C0S6

MaxQB - The MaxQuant DataBase

More...MaxQBi		P0C0S6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0C0S6

PRoteomics IDEntifications database

More...PRIDEi		P0C0S6

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P0C0S6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P0C0S6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P0C0S6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000037894, Expressed in primitive streak and 290 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P0C0S6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via M6 cassette) with ANP32E; leading to removal of H2A.Z/H2AZ1 from the nucleosome (By similarity). The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B (By similarity). H2AZ1 interacts with INCENP (PubMed:12660166).

Interacts with VPS72 (via N-terminal domain).

Interacts with PWWP2A (By similarity).

Interacts with FH (when phosphorylated by PRKDC) (By similarity).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		206173, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5715, Nucleosome, variant H3.1-H2A.Z-H2B.1

Protein interaction database and analysis system

More...IntActi		P0C0S6, 10 interactors

Molecular INTeraction database

More...MINTi		P0C0S6

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000036907

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P0C0S6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P0C0S6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0C0S6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni1 – 17Required for interaction with INCENP1 PublicationAdd BLAST17
Regioni89 – 100M6 cassetteBy similarityAdd BLAST12
Regioni93 – 103Required for interaction with INCENP1 PublicationAdd BLAST11
Regioni120 – 128Required for interaction with PWWP2ABy similarity9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1757, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00900000140979

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_062828_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0C0S6

Identification of Orthologs from Complete Genome Data

More...OMAi		WHCQAGG

Database of Orthologous Groups

More...OrthoDBi		1504122at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0C0S6

TreeFam database of animal gene trees

More...TreeFami		TF354232

Family and domain databases

Conserved Domains Database

More...CDDi		cd00074, H2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009072, Histone-fold
IPR002119, Histone_H2A
IPR007125, Histone_H2A/H2B/H3
IPR032454, Histone_H2A_C
IPR032458, Histone_H2A_CS

The PANTHER Classification System

More...PANTHERi		PTHR23430, PTHR23430, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00125, Histone, 1 hit
PF16211, Histone_H2A_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00620, HISTONEH2A

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00414, H2A, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47113, SSF47113, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00046, HISTONE_H2A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P0C0S6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT 
        60         70         80         90        100
AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL 
       110        120 
IKATIAGGGV IPHIHKSLIG KKGQQKTV
Length:128
Mass (Da):13,553
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE024E53818230371
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UA95Q3UA95_MOUSE
Histone H2A
H2az1 H2afz
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWL7G3UWL7_MOUSE
Histone H2A
H2az1
87Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UX40G3UX40_MOUSE
Histone H2A.Z
H2az1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12K → E in BAE30460 (PubMed:16141072).Curated1
Sequence conflicti29P → A in BAE26959 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U70494 mRNA Translation: AAB09578.1
AY074806 mRNA Translation: AAL71864.1
AK028176 mRNA Translation: BAC25791.1
AK088704 mRNA Translation: BAC40515.1
AK143572 mRNA Translation: BAE25443.1
AK146181 mRNA Translation: BAE26959.1
AK150454 mRNA Translation: BAE29574.1
AK151052 mRNA Translation: BAE30069.1
AK151509 mRNA Translation: BAE30460.1
AK151868 mRNA Translation: BAE30756.1
AK152398 mRNA Translation: BAE31186.1
AK152848 mRNA Translation: BAE31541.1
AK168178 mRNA Translation: BAE40138.1
BC079903 mRNA Translation: AAH79903.1
BC147478 mRNA Translation: AAI47479.1
BC158035 mRNA Translation: AAI58036.1
BC171999 mRNA Translation: AAI71999.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38647.1

NCBI Reference Sequences

More...RefSeqi		NP_058030.1, NM_016750.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000041045; ENSMUSP00000036907; ENSMUSG00000037894

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51788

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:51788

UCSC genome browser

More...UCSCi		uc008rmo.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70494 mRNA Translation: AAB09578.1
AY074806 mRNA Translation: AAL71864.1
AK028176 mRNA Translation: BAC25791.1
AK088704 mRNA Translation: BAC40515.1
AK143572 mRNA Translation: BAE25443.1
AK146181 mRNA Translation: BAE26959.1
AK150454 mRNA Translation: BAE29574.1
AK151052 mRNA Translation: BAE30069.1
AK151509 mRNA Translation: BAE30460.1
AK151868 mRNA Translation: BAE30756.1
AK152398 mRNA Translation: BAE31186.1
AK152848 mRNA Translation: BAE31541.1
AK168178 mRNA Translation: BAE40138.1
BC079903 mRNA Translation: AAH79903.1
BC147478 mRNA Translation: AAI47479.1
BC158035 mRNA Translation: AAI58036.1
BC171999 mRNA Translation: AAI71999.1
CCDSiCCDS38647.1
RefSeqiNP_058030.1, NM_016750.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7M1Xelectron microscopy3.70C/G1-128[»]
AlphaFoldDBiP0C0S6
SMRiP0C0S6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi206173, 9 interactors
ComplexPortaliCPX-5715, Nucleosome, variant H3.1-H2A.Z-H2B.1
IntActiP0C0S6, 10 interactors
MINTiP0C0S6
STRINGi10090.ENSMUSP00000036907

PTM databases

iPTMnetiP0C0S6
PhosphoSitePlusiP0C0S6

Proteomic databases

EPDiP0C0S6
jPOSTiP0C0S6
MaxQBiP0C0S6
PaxDbiP0C0S6
PRIDEiP0C0S6
TopDownProteomicsiP0C0S6

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P0C0S6, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45022, 545 antibodies from 38 providers

The DNASU plasmid repository

More...DNASUi		51788

Genome annotation databases

EnsembliENSMUST00000041045; ENSMUSP00000036907; ENSMUSG00000037894
GeneIDi51788
KEGGimmu:51788
UCSCiuc008rmo.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3015
MGIiMGI:1888388, H2az1
VEuPathDBiHostDB:ENSMUSG00000037894

Phylogenomic databases

eggNOGiKOG1757, Eukaryota
GeneTreeiENSGT00900000140979
HOGENOMiCLU_062828_2_2_1
InParanoidiP0C0S6
OMAiWHCQAGG
OrthoDBi1504122at2759
PhylomeDBiP0C0S6
TreeFamiTF354232

Enzyme and pathway databases

ReactomeiR-MMU-110330, Recognition and association of DNA glycosylase with site containing an affected purine
R-MMU-110331, Cleavage of the damaged purine
R-MMU-212300, PRC2 methylates histones and DNA
R-MMU-2299718, Condensation of Prophase Chromosomes
R-MMU-2559580, Oxidative Stress Induced Senescence
R-MMU-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586, DNA Damage/Telomere Stress Induced Senescence
R-MMU-427359, SIRT1 negatively regulates rRNA expression
R-MMU-427413, NoRC negatively regulates rRNA expression
R-MMU-5250924, B-WICH complex positively regulates rRNA expression
R-MMU-5578749, Transcriptional regulation by small RNAs
R-MMU-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-606279, Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-68616, Assembly of the ORC complex at the origin of replication
R-MMU-73728, RNA Polymerase I Promoter Opening
R-MMU-73772, RNA Polymerase I Promoter Escape
R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519, Estrogen-dependent gene expression
R-MMU-9670095, Inhibition of DNA recombination at telomere

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51788, 29 hits in 73 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		H2afz, mouse

Protein Ontology

More...PROi		PR:P0C0S6
RNActiP0C0S6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000037894, Expressed in primitive streak and 290 other tissues
GenevisibleiP0C0S6, MM

Family and domain databases

CDDicd00074, H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072, Histone-fold
IPR002119, Histone_H2A
IPR007125, Histone_H2A/H2B/H3
IPR032454, Histone_H2A_C
IPR032458, Histone_H2A_CS
PANTHERiPTHR23430, PTHR23430, 1 hit
PfamiView protein in Pfam
PF00125, Histone, 1 hit
PF16211, Histone_H2A_C, 1 hit
PRINTSiPR00620, HISTONEH2A
SMARTiView protein in SMART
SM00414, H2A, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046, HISTONE_H2A, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2AZ_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C0S6
Secondary accession number(s): B2RXZ3
, P17317, Q3UA55, Q3UK43, Q68FD2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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