UniProtKB - P0C0S6 (H2AZ_MOUSE)
Histone H2A.Z
H2az1
Functioni
Miscellaneous
GO - Molecular functioni
- chromatin DNA binding Source: MGI
- DNA binding Source: GO_Central
- nucleosomal DNA binding Source: MGI
- protein heterodimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
GO - Biological processi
- cellular response to estradiol stimulus Source: MGI
- cellular response to insulin stimulus Source: MGI
- chromatin organization Source: GO_Central
- chromatin silencing Source: GO_Central
- multicellular organism development Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Enzyme and pathway databases
Reactomei | R-MMU-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-MMU-110331, Cleavage of the damaged purine R-MMU-212300, PRC2 methylates histones and DNA R-MMU-2299718, Condensation of Prophase Chromosomes R-MMU-2559586, DNA Damage/Telomere Stress Induced Senescence R-MMU-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-9670095, Inhibition of DNA recombination at telomere |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H2A.ZShort name: H2A/z |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1888388, H2az1 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Chromosome 2 Publications
Note: Enriched in constitutive heterochromatin (PubMed:12660166, PubMed:15195148). Absent from facultative heterochromatin of the inactive X chromosome (PubMed:12660166).2 Publications
Nucleus
- nuclear chromatin Source: GO_Central
- nuclear euchromatin Source: MGI
- nuclear heterochromatin Source: MGI
- nucleus Source: MGI
Other locations
- nucleosome Source: UniProtKB-KW
Keywords - Cellular componenti
Chromosome, Nucleosome core, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCurated | |||
ChainiPRO_0000055298 | 2 – 128 | Histone H2A.ZAdd BLAST | 127 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 5 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 5 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 8 | N6-acetyllysine; alternate1 Publication | 1 | |
Modified residuei | 8 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 12 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 14 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 122 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Ubl conjugationProteomic databases
EPDi | P0C0S6 |
jPOSTi | P0C0S6 |
MaxQBi | P0C0S6 |
PaxDbi | P0C0S6 |
PRIDEi | P0C0S6 |
TopDownProteomicsi | P0C0S6 |
PTM databases
iPTMneti | P0C0S6 |
PhosphoSitePlusi | P0C0S6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037894, Expressed in primitive streak and 282 other tissues |
Genevisiblei | P0C0S6, MM |
Interactioni
Subunit structurei
Interacts (via M6 cassette) with ANP32E; leading to removal of H2A.Z/H2AZ1 from the nucleosome (By similarity). The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B (By similarity). H2AZ1 interacts with INCENP (PubMed:12660166).
Interacts with VPS72 (via N-terminal domain).
Interacts with PWWP2A (By similarity).
Interacts with FH (when phosphorylated by PRKDC) (By similarity).
By similarity1 PublicationGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 206173, 6 interactors |
ComplexPortali | CPX-5715, Nucleosome, variant H3.1-H2A.Z-H2B.1 |
IntActi | P0C0S6, 13 interactors |
MINTi | P0C0S6 |
STRINGi | 10090.ENSMUSP00000036907 |
Miscellaneous databases
RNActi | P0C0S6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 17 | Required for interaction with INCENP1 PublicationAdd BLAST | 17 | |
Regioni | 89 – 100 | M6 cassetteBy similarityAdd BLAST | 12 | |
Regioni | 93 – 103 | Required for interaction with INCENP1 PublicationAdd BLAST | 11 | |
Regioni | 120 – 128 | Required for interaction with PWWP2ABy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1757, Eukaryota |
GeneTreei | ENSGT00900000140979 |
HOGENOMi | CLU_062828_2_2_1 |
InParanoidi | P0C0S6 |
OMAi | QYQLRAN |
OrthoDBi | 1504122at2759 |
PhylomeDBi | P0C0S6 |
TreeFami | TF354232 |
Family and domain databases
CDDi | cd00074, H2A, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR002119, Histone_H2A IPR007125, Histone_H2A/H2B/H3 IPR032454, Histone_H2A_C IPR032458, Histone_H2A_CS |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF16211, Histone_H2A_C, 1 hit |
PRINTSi | PR00620, HISTONEH2A |
SMARTi | View protein in SMART SM00414, H2A, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00046, HISTONE_H2A, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT
60 70 80 90 100
AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL
110 120
IKATIAGGGV IPHIHKSLIG KKGQQKTV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3UA95 | Q3UA95_MOUSE | Histone H2A | H2az1 H2afz | 105 | Annotation score: | ||
G3UWL7 | G3UWL7_MOUSE | Histone H2A | H2az1 | 87 | Annotation score: | ||
G3UX40 | G3UX40_MOUSE | Histone H2A.Z | H2az1 | 54 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | K → E in BAE30460 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 29 | P → A in BAE26959 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70494 mRNA Translation: AAB09578.1 AY074806 mRNA Translation: AAL71864.1 AK028176 mRNA Translation: BAC25791.1 AK088704 mRNA Translation: BAC40515.1 AK143572 mRNA Translation: BAE25443.1 AK146181 mRNA Translation: BAE26959.1 AK150454 mRNA Translation: BAE29574.1 AK151052 mRNA Translation: BAE30069.1 AK151509 mRNA Translation: BAE30460.1 AK151868 mRNA Translation: BAE30756.1 AK152398 mRNA Translation: BAE31186.1 AK152848 mRNA Translation: BAE31541.1 AK168178 mRNA Translation: BAE40138.1 BC079903 mRNA Translation: AAH79903.1 BC147478 mRNA Translation: AAI47479.1 BC158035 mRNA Translation: AAI58036.1 BC171999 mRNA Translation: AAI71999.1 |
CCDSi | CCDS38647.1 |
RefSeqi | NP_058030.1, NM_016750.3 |
Genome annotation databases
Ensembli | ENSMUST00000041045; ENSMUSP00000036907; ENSMUSG00000037894 |
GeneIDi | 51788 |
KEGGi | mmu:51788 |
UCSCi | uc008rmo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70494 mRNA Translation: AAB09578.1 AY074806 mRNA Translation: AAL71864.1 AK028176 mRNA Translation: BAC25791.1 AK088704 mRNA Translation: BAC40515.1 AK143572 mRNA Translation: BAE25443.1 AK146181 mRNA Translation: BAE26959.1 AK150454 mRNA Translation: BAE29574.1 AK151052 mRNA Translation: BAE30069.1 AK151509 mRNA Translation: BAE30460.1 AK151868 mRNA Translation: BAE30756.1 AK152398 mRNA Translation: BAE31186.1 AK152848 mRNA Translation: BAE31541.1 AK168178 mRNA Translation: BAE40138.1 BC079903 mRNA Translation: AAH79903.1 BC147478 mRNA Translation: AAI47479.1 BC158035 mRNA Translation: AAI58036.1 BC171999 mRNA Translation: AAI71999.1 |
CCDSi | CCDS38647.1 |
RefSeqi | NP_058030.1, NM_016750.3 |
3D structure databases
SMRi | P0C0S6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 206173, 6 interactors |
ComplexPortali | CPX-5715, Nucleosome, variant H3.1-H2A.Z-H2B.1 |
IntActi | P0C0S6, 13 interactors |
MINTi | P0C0S6 |
STRINGi | 10090.ENSMUSP00000036907 |
PTM databases
iPTMneti | P0C0S6 |
PhosphoSitePlusi | P0C0S6 |
Proteomic databases
EPDi | P0C0S6 |
jPOSTi | P0C0S6 |
MaxQBi | P0C0S6 |
PaxDbi | P0C0S6 |
PRIDEi | P0C0S6 |
TopDownProteomicsi | P0C0S6 |
Protocols and materials databases
ABCDi | P0C0S6, 1 sequenced antibody |
Antibodypediai | 45022, 491 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000041045; ENSMUSP00000036907; ENSMUSG00000037894 |
GeneIDi | 51788 |
KEGGi | mmu:51788 |
UCSCi | uc008rmo.2, mouse |
Organism-specific databases
CTDi | 3015 |
MGIi | MGI:1888388, H2az1 |
Phylogenomic databases
eggNOGi | KOG1757, Eukaryota |
GeneTreei | ENSGT00900000140979 |
HOGENOMi | CLU_062828_2_2_1 |
InParanoidi | P0C0S6 |
OMAi | QYQLRAN |
OrthoDBi | 1504122at2759 |
PhylomeDBi | P0C0S6 |
TreeFami | TF354232 |
Enzyme and pathway databases
Reactomei | R-MMU-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-MMU-110331, Cleavage of the damaged purine R-MMU-212300, PRC2 methylates histones and DNA R-MMU-2299718, Condensation of Prophase Chromosomes R-MMU-2559586, DNA Damage/Telomere Stress Induced Senescence R-MMU-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-9670095, Inhibition of DNA recombination at telomere |
Miscellaneous databases
BioGRID-ORCSi | 51788, 10 hits in 18 CRISPR screens |
ChiTaRSi | H2afz, mouse |
PROi | PR:P0C0S6 |
RNActi | P0C0S6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037894, Expressed in primitive streak and 282 other tissues |
Genevisiblei | P0C0S6, MM |
Family and domain databases
CDDi | cd00074, H2A, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR002119, Histone_H2A IPR007125, Histone_H2A/H2B/H3 IPR032454, Histone_H2A_C IPR032458, Histone_H2A_CS |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF16211, Histone_H2A_C, 1 hit |
PRINTSi | PR00620, HISTONEH2A |
SMARTi | View protein in SMART SM00414, H2A, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00046, HISTONE_H2A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H2AZ_MOUSE | |
Accessioni | P0C0S6Primary (citable) accession number: P0C0S6 Secondary accession number(s): B2RXZ3 Q68FD2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families