H2afz

Functionⁱ

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Essential for early development.3 Publications

Miscellaneous

Down-regulation of H2afz by RNA interference leads to death at early embryonic stages.

GO - Molecular functionⁱ

chromatin DNA binding Source: MGI
DNA binding Source: GO_Central
nucleosomal DNA binding Source: MGI
protein heterodimerization activity Source: InterPro
RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to estradiol stimulus Source: MGI
cellular response to insulin stimulus Source: MGI
chromatin silencing Source: GO_Central
multicellular organism development Source: UniProtKB-KW
positive regulation of transcription by RNA polymerase II Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding

Molecular function

Developmental protein, DNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex R-MMU-212300 PRC2 methylates histones and DNA R-MMU-2299718 Condensation of Prophase Chromosomes R-MMU-2559580 Oxidative Stress Induced Senescence R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence R-MMU-3214858 RMTs methylate histone arginines R-MMU-427359 SIRT1 negatively regulates rRNA expression R-MMU-427413 NoRC negatively regulates rRNA expression R-MMU-5250924 B-WICH complex positively regulates rRNA expression R-MMU-5578749 Transcriptional regulation by small RNAs R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-MMU-73728 RNA Polymerase I Promoter Opening R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-212300 PRC2 methylates histones and DNA
R-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-427359 SIRT1 negatively regulates rRNA expression
R-MMU-427413 NoRC negatively regulates rRNA expression
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-73728 RNA Polymerase I Promoter Opening
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone H2A.Z Short name: H2A/z
Gene namesⁱ	Name:H2afz Synonyms:H2az
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1888388 H2afz

Keywords - Cellular componentⁱ

Chromosome, Nucleosome core, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCurated
ChainⁱPRO_0000055298	2 – 128	Histone H2A.ZAdd BLAST		127

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	5	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	5	N6-methyllysine; alternateBy similarity	1
Modified residueⁱ	8	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	8	N6-methyllysine; alternateBy similarity	1
Modified residueⁱ	12	N6-acetyllysine1 Publication	1
Modified residueⁱ	14	N6-acetyllysineBy similarity	1
Cross-linkⁱ	122	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationⁱ

Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.By similarity

Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.2 Publications

Not phosphorylated.1 Publication

Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDⁱ	P0C0S6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P0C0S6
PaxDbⁱ	P0C0S6
PRIDEⁱ	P0C0S6
TopDownProteomicsⁱ	P0C0S6

PTM databases

iPTMnetⁱ	P0C0S6
PhosphoSitePlusⁱ	P0C0S6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000037894
CleanExⁱ	MM_H2AFZ
ExpressionAtlasⁱ	P0C0S6 baseline and differential
Genevisibleⁱ	P0C0S6 MM

Interactionⁱ

Subunit structureⁱ

Interacts (via M6 cassette) with ANP32E; leading to removal of H2A.Z/H2AFZ from the nucleosome (By similarity). The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms a heterodimer with H2B (By similarity). H2AFZ interacts with INCENP (PubMed:12660166). Interacts with VPS72 (via N-terminal domain). Interacts with PWWP2A (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	206173, 5 interactors
IntActⁱ	P0C0S6, 13 interactors
Molecular INTeraction database More...MINTⁱ	P0C0S6
STRINGⁱ	10090.ENSMUSP00000036907

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0C0S6
SMRⁱ	P0C0S6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 17	Required for interaction with INCENP1 PublicationAdd BLAST	17
Regionⁱ	89 – 100	M6 cassetteBy similarityAdd BLAST	12
Regionⁱ	93 – 103	Required for interaction with INCENP1 PublicationAdd BLAST	11
Regionⁱ	120 – 128	Required for interaction with PWWP2ABy similarity	9

Sequence similaritiesⁱ

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1757 Eukaryota COG5262 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140979
HOGENOMⁱ	HOG000234652
HOVERGENⁱ	HBG009342
InParanoidⁱ	P0C0S6
KEGG Orthology (KO) More...KOⁱ	K11251
OMAⁱ	KGTMSSK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XGD
PhylomeDBⁱ	P0C0S6
TreeFamⁱ	TF354232

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00074 H2A, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR009072 Histone-fold IPR002119 Histone_H2A IPR007125 Histone_H2A/H2B/H3 IPR032454 Histone_H2A_C IPR032458 Histone_H2A_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125 Histone, 1 hit PF16211 Histone_H2A_C, 1 hit
PRINTSⁱ	PR00620 HISTONEH2A
SMARTⁱ	View protein in SMART SM00414 H2A, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit
PROSITEⁱ	View protein in PROSITE PS00046 HISTONE_H2A, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P0C0S6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT 
        60         70         80         90        100
AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL 
       110        120 
IKATIAGGGV IPHIHKSLIG KKGQQKTV

Length:128

Mass (Da):13,553

Last modified:January 23, 2007 - v2

Checksum:ⁱE024E53818230371

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	12	K → E in BAE30460 (PubMed:16141072).Curated		1
Sequence conflictⁱ	29	P → A in BAE26959 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U70494 mRNA Translation: AAB09578.1 AY074806 mRNA Translation: AAL71864.1 AK028176 mRNA Translation: BAC25791.1 AK088704 mRNA Translation: BAC40515.1 AK143572 mRNA Translation: BAE25443.1 AK146181 mRNA Translation: BAE26959.1 AK150454 mRNA Translation: BAE29574.1 AK151052 mRNA Translation: BAE30069.1 AK151509 mRNA Translation: BAE30460.1 AK151868 mRNA Translation: BAE30756.1 AK152398 mRNA Translation: BAE31186.1 AK152848 mRNA Translation: BAE31541.1 AK168178 mRNA Translation: BAE40138.1 BC079903 mRNA Translation: AAH79903.1 BC147478 mRNA Translation: AAI47479.1 BC158035 mRNA Translation: AAI58036.1 BC171999 mRNA Translation: AAI71999.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS38647.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058030.1, NM_016750.3
UniGeneⁱ	Mm.117541 Mm.372513 Mm.465508

Genome annotation databases

Ensemblⁱ	ENSMUST00000041045; ENSMUSP00000036907; ENSMUSG00000037894
GeneIDⁱ	51788
KEGGⁱ	mmu:51788
UCSC genome browser More...UCSCⁱ	uc008rmo.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P0C0S6	Histone H2A.Z	)	HUMAN		128
Histone H2A.Z		BOVIN		128
Histone H2A.Z		ONCMY		128
Histone H2A.Z		PONAB		128
Histone H2A.Z		RAT		128
+28

Protein	Similar proteins		Species	Score	Length
P0C0S6	Histone H2A.Z	)	HUMAN		128
Histone H2A.Z		BOVIN		128
Histone H2A.Z		ONCMY		128
Histone H2A.Z		PONAB		128
Histone H2A.Z		RAT		128
+32

Protein	Similar proteins		Species	Score	Length
P0C0S6	Histone H2A.Z	)	HUMAN		128
Histone H2A.Z		BOVIN		128
Histone H2A.Z		ONCMY		128
Histone H2A.Z		PONAB		128
Histone H2A.Z		RAT		128
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U70494 mRNA Translation: AAB09578.1 AY074806 mRNA Translation: AAL71864.1 AK028176 mRNA Translation: BAC25791.1 AK088704 mRNA Translation: BAC40515.1 AK143572 mRNA Translation: BAE25443.1 AK146181 mRNA Translation: BAE26959.1 AK150454 mRNA Translation: BAE29574.1 AK151052 mRNA Translation: BAE30069.1 AK151509 mRNA Translation: BAE30460.1 AK151868 mRNA Translation: BAE30756.1 AK152398 mRNA Translation: BAE31186.1 AK152848 mRNA Translation: BAE31541.1 AK168178 mRNA Translation: BAE40138.1 BC079903 mRNA Translation: AAH79903.1 BC147478 mRNA Translation: AAI47479.1 BC158035 mRNA Translation: AAI58036.1 BC171999 mRNA Translation: AAI71999.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS38647.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058030.1, NM_016750.3
UniGeneⁱ	Mm.117541 Mm.372513 Mm.465508

3D structure databases

ProteinModelPortalⁱ	P0C0S6
SMRⁱ	P0C0S6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	206173, 5 interactors
IntActⁱ	P0C0S6, 13 interactors
Molecular INTeraction database More...MINTⁱ	P0C0S6
STRINGⁱ	10090.ENSMUSP00000036907

PTM databases

iPTMnetⁱ	P0C0S6
PhosphoSitePlusⁱ	P0C0S6

Proteomic databases

EPDⁱ	P0C0S6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P0C0S6
PaxDbⁱ	P0C0S6
PRIDEⁱ	P0C0S6
TopDownProteomicsⁱ	P0C0S6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000041045; ENSMUSP00000036907; ENSMUSG00000037894
GeneIDⁱ	51788
KEGGⁱ	mmu:51788
UCSC genome browser More...UCSCⁱ	uc008rmo.2 mouse

Organism-specific databases

CTDⁱ	3015
MGIⁱ	MGI:1888388 H2afz

Phylogenomic databases

eggNOGⁱ	KOG1757 Eukaryota COG5262 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140979
HOGENOMⁱ	HOG000234652
HOVERGENⁱ	HBG009342
InParanoidⁱ	P0C0S6
KEGG Orthology (KO) More...KOⁱ	K11251
OMAⁱ	KGTMSSK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XGD
PhylomeDBⁱ	P0C0S6
TreeFamⁱ	TF354232

Enzyme and pathway databases

Reactomeⁱ	R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex R-MMU-212300 PRC2 methylates histones and DNA R-MMU-2299718 Condensation of Prophase Chromosomes R-MMU-2559580 Oxidative Stress Induced Senescence R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence R-MMU-3214858 RMTs methylate histone arginines R-MMU-427359 SIRT1 negatively regulates rRNA expression R-MMU-427413 NoRC negatively regulates rRNA expression R-MMU-5250924 B-WICH complex positively regulates rRNA expression R-MMU-5578749 Transcriptional regulation by small RNAs R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-MMU-73728 RNA Polymerase I Promoter Opening R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-212300 PRC2 methylates histones and DNA
R-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-427359 SIRT1 negatively regulates rRNA expression
R-MMU-427413 NoRC negatively regulates rRNA expression
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-73728 RNA Polymerase I Promoter Opening
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0C0S6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037894
CleanExⁱ	MM_H2AFZ
ExpressionAtlasⁱ	P0C0S6 baseline and differential
Genevisibleⁱ	P0C0S6 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00074 H2A, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR009072 Histone-fold IPR002119 Histone_H2A IPR007125 Histone_H2A/H2B/H3 IPR032454 Histone_H2A_C IPR032458 Histone_H2A_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125 Histone, 1 hit PF16211 Histone_H2A_C, 1 hit
PRINTSⁱ	PR00620 HISTONEH2A
SMARTⁱ	View protein in SMART SM00414 H2A, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit
PROSITEⁱ	View protein in PROSITE PS00046 HISTONE_H2A, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H2AZ_MOUSE
Accessionⁱ	P0C0S6Primary (citable) accession number: P0C0S6 Secondary accession number(s): B2RXZ3 , P17317, Q3UA55, Q3UK43, Q68FD2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	January 23, 2007
	Last modified:	June 20, 2018
	This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P0C0S6 (H2AZ_MOUSE)

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Histone H2A.Z

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ