UniProtKB - P0C0S4 (H2AZ_BOVIN)
Histone H2A.Z
H2AZ1
Functioni
GO - Molecular functioni
- DNA binding Source: GO_Central
- nucleosomal DNA binding Source: Ensembl
- protein heterodimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- cellular response to estradiol stimulus Source: Ensembl
- chromatin silencing Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H2A.ZShort name: H2A/z |
Gene namesi | Name:H2AZ1 Synonyms:H2AZ |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:83610, H2AZ1 |
Subcellular locationi
Nucleus
Other locations
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- euchromatin Source: Ensembl
- heterochromatin Source: Ensembl
- nucleosome Source: UniProtKB-KW
Keywords - Cellular componenti
Chromosome, Nucleosome core, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000055296 | 2 – 128 | Histone H2A.ZAdd BLAST | 127 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 5 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 5 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 8 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 8 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 12 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 12 | N6-lactoyllysine; alternateBy similarity | 1 | |
Modified residuei | 14 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 14 | N6-lactoyllysine; alternateBy similarity | 1 | |
Modified residuei | 116 | N6-lactoyllysineBy similarity | 1 | |
Cross-linki | 122 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarityCurated |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Ubl conjugationProteomic databases
PeptideAtlasi | P0C0S4 |
PRIDEi | P0C0S4 |
Interactioni
Subunit structurei
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B. H2AZ1 interacts with INCENP.
Interacts (via M6 cassette) with ANP32E; leading to removal of H2A.Z/H2AZ1 from the nucleosome.
Interacts with VPS72 (via N-terminal domain).
Interacts with PWWP2A.
Interacts with FH (when phosphorylated by PRKDC).
By similarityGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 17 | Required for interaction with INCENPBy similarityAdd BLAST | 16 | |
Regioni | 89 – 100 | M6 cassetteBy similarityAdd BLAST | 12 | |
Regioni | 93 – 103 | Required for interaction with INCENPBy similarityAdd BLAST | 11 | |
Regioni | 120 – 128 | Required for interaction with PWWP2ABy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00900000140979 |
InParanoidi | P0C0S4 |
OrthoDBi | 1504122at2759 |
Family and domain databases
CDDi | cd00074, H2A, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR002119, Histone_H2A IPR007125, Histone_H2A/H2B/H3 IPR032454, Histone_H2A_C IPR032458, Histone_H2A_CS |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF16211, Histone_H2A_C, 1 hit |
PRINTSi | PR00620, HISTONEH2A |
SMARTi | View protein in SMART SM00414, H2A, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00046, HISTONE_H2A, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT
60 70 80 90 100
AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL
110 120
IKATIAGGGV IPHIHKSLIG KKGQQKTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52318 mRNA Translation: CAA36554.1 M37585 mRNA Translation: AAA30566.1 BC109743 mRNA Translation: AAI09744.1 |
PIRi | S03642 |
RefSeqi | NP_777234.1, NM_174809.2 XP_010804249.1, XM_010805947.2 |
Genome annotation databases
Ensembli | ENSBTAT00000005802; ENSBTAP00000005802; ENSBTAG00000004428 |
GeneIDi | 287016 |
KEGGi | bta:287016 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52318 mRNA Translation: CAA36554.1 M37585 mRNA Translation: AAA30566.1 BC109743 mRNA Translation: AAI09744.1 |
PIRi | S03642 |
RefSeqi | NP_777234.1, NM_174809.2 XP_010804249.1, XM_010805947.2 |
3D structure databases
SMRi | P0C0S4 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | P0C0S4 |
PRIDEi | P0C0S4 |
Genome annotation databases
Ensembli | ENSBTAT00000005802; ENSBTAP00000005802; ENSBTAG00000004428 |
GeneIDi | 287016 |
KEGGi | bta:287016 |
Organism-specific databases
CTDi | 3015 |
VGNCi | VGNC:83610, H2AZ1 |
Phylogenomic databases
GeneTreei | ENSGT00900000140979 |
InParanoidi | P0C0S4 |
OrthoDBi | 1504122at2759 |
Gene expression databases
ExpressionAtlasi | P0C0S4, baseline and differential |
Family and domain databases
CDDi | cd00074, H2A, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR002119, Histone_H2A IPR007125, Histone_H2A/H2B/H3 IPR032454, Histone_H2A_C IPR032458, Histone_H2A_CS |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF16211, Histone_H2A_C, 1 hit |
PRINTSi | PR00620, HISTONEH2A |
SMARTi | View protein in SMART SM00414, H2A, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00046, HISTONE_H2A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H2AZ_BOVIN | |
Accessioni | P0C0S4Primary (citable) accession number: P0C0S4 Secondary accession number(s): P17317, Q32L66 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 102 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families