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Protein

Neuropeptide S

Gene

Nps

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.1 Publication

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide S
Gene namesi
Name:Nps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3642232 Nps

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000004294124 – 69Add BLAST46
PeptideiPRO_000004294270 – 89Neuropeptide SAdd BLAST20

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP0C0P8
PRIDEiP0C0P8

Expressioni

Gene expression databases

BgeeiENSMUSG00000073804 Expressed in 11 organ(s), highest expression level in brain
CleanExiMM_NPS
ExpressionAtlasiP0C0P8 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095597

Structurei

3D structure databases

SMRiP0C0P8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J45R Eukaryota
ENOG41115PF LUCA
GeneTreeiENSGT00400000024769
HOGENOMiHOG000113845
HOVERGENiHBG082056
InParanoidiP0C0P8
OrthoDBiEOG091G14R3
PhylomeDBiP0C0P8

Family and domain databases

InterProiView protein in InterPro
IPR028138 Neuropeptide_S
PANTHERiPTHR36679 PTHR36679, 1 hit
PfamiView protein in Pfam
PF14993 Neuropeptide_S, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0C0P8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGSLKLSFV LALSLSVMHV LWCYPVLSSK VPGKPDYFLI LLSSCPARLE
60 70 80
GSDRLAFLKP ILEKTSMKRS FRNGVGSGAK KTSFRRAKQ
Length:89
Mass (Da):9,861
Last modified:November 22, 2005 - v1
Checksum:iA2C8208D20107D59
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRF8A0A1B0GRF8_MOUSE
Neuropeptide S
Nps
72Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BD168690 Unassigned DNA No translation available.
CCDSiCCDS52420.1
RefSeqiNP_001157083.1, NM_001163611.1
UniGeneiMm.192092

Genome annotation databases

EnsembliENSMUST00000097983; ENSMUSP00000095597; ENSMUSG00000073804
GeneIDi100043254
KEGGimmu:100043254
UCSCiuc012fvj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BD168690 Unassigned DNA No translation available.
CCDSiCCDS52420.1
RefSeqiNP_001157083.1, NM_001163611.1
UniGeneiMm.192092

3D structure databases

SMRiP0C0P8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095597

Proteomic databases

PaxDbiP0C0P8
PRIDEiP0C0P8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097983; ENSMUSP00000095597; ENSMUSG00000073804
GeneIDi100043254
KEGGimmu:100043254
UCSCiuc012fvj.1 mouse

Organism-specific databases

CTDi594857
MGIiMGI:3642232 Nps

Phylogenomic databases

eggNOGiENOG410J45R Eukaryota
ENOG41115PF LUCA
GeneTreeiENSGT00400000024769
HOGENOMiHOG000113845
HOVERGENiHBG082056
InParanoidiP0C0P8
OrthoDBiEOG091G14R3
PhylomeDBiP0C0P8

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:P0C0P8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073804 Expressed in 11 organ(s), highest expression level in brain
CleanExiMM_NPS
ExpressionAtlasiP0C0P8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR028138 Neuropeptide_S
PANTHERiPTHR36679 PTHR36679, 1 hit
PfamiView protein in Pfam
PF14993 Neuropeptide_S, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPS_MOUSE
AccessioniPrimary (citable) accession number: P0C0P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 7, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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