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Protein

Neuropeptide S

Gene

NPS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).By similarity2 Publications

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide S
Gene namesi
Name:NPS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000214285.2
HGNCiHGNC:33940 NPS
MIMi609513 gene
neXtProtiNX_P0C0P6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi594857
OpenTargetsiENSG00000214285
PharmGKBiPA162398160

Chemistry databases

ChEMBLiCHEMBL3596086

Polymorphism and mutation databases

BioMutaiNPS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000004288824 – 67Add BLAST44
PeptideiPRO_000004288970 – 89Neuropeptide SAdd BLAST20

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP0C0P6
PeptideAtlasiP0C0P6
PRIDEiP0C0P6
ProteomicsDBi52294

Expressioni

Gene expression databases

BgeeiENSG00000214285
CleanExiHS_NPS

Organism-specific databases

HPAiCAB020139

Interactioni

Protein-protein interaction databases

IntActiP0C0P6, 1 interactor
STRINGi9606.ENSP00000381105

Structurei

3D structure databases

ProteinModelPortaliP0C0P6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J45R Eukaryota
ENOG41115PF LUCA
GeneTreeiENSGT00400000024769
HOGENOMiHOG000113845
HOVERGENiHBG082056
InParanoidiP0C0P6
OMAiMKRSFRN
OrthoDBiEOG091G14R3
PhylomeDBiP0C0P6

Family and domain databases

InterProiView protein in InterPro
IPR028138 Neuropeptide_S
PANTHERiPTHR36679 PTHR36679, 1 hit
PfamiView protein in Pfam
PF14993 Neuropeptide_S, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD
60 70 80
RSKELAFLKP ILEKMFVKRS FRNGVGTGMK KTSFQRAKS
Length:89
Mass (Da):10,103
Last modified:November 22, 2005 - v1
Checksum:i41574555F540A7A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05123914S → L. Corresponds to variant dbSNP:rs990310Ensembl.1
Natural variantiVAR_05124075V → L. Corresponds to variant dbSNP:rs4751440Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BD168686 mRNA No translation available.
AL355316 Genomic DNA No translation available.
BC148465 mRNA Translation: AAI48466.1
BC156665 mRNA Translation: AAI56666.1
CCDSiCCDS41577.1
RefSeqiNP_001025184.1, NM_001030013.1
UniGeneiHs.643423

Genome annotation databases

EnsembliENST00000398023; ENSP00000381105; ENSG00000214285
GeneIDi594857
KEGGihsa:594857
UCSCiuc001ljx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNPS_HUMAN
AccessioniPrimary (citable) accession number: P0C0P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 20, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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