NPS

Functionⁱ

Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).By similarity2 Publications

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: Reactome
neuropeptide signaling pathway Source: UniProtKB-KW
positive regulation of action potential Source: Ensembl
positive regulation of circadian sleep/wake cycle, wakefulness Source: Ensembl
positive regulation of synaptic transmission, GABAergic Source: Ensembl
positive regulation of synaptic transmission, glutamatergic Source: Ensembl
visual learning Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Neuropeptide

Molecular function

Neuropeptide

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuropeptide S
Gene namesⁱ	Name:NPS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000214285.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33940 NPS
MIMⁱ	609513 gene
neXtProtⁱ	NX_P0C0P6

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	594857
Open Targets More...OpenTargetsⁱ	ENSG00000214285
PharmGKBⁱ	PA162398160

Chemistry databases

ChEMBLⁱ	CHEMBL3596086

ChEMBLⁱ

CHEMBL3596086

Polymorphism and mutation databases

BioMutaⁱ	NPS

BioMutaⁱ

NPS

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST	23
PropeptideⁱPRO_0000042888	24 – 67	Add BLAST	44
PeptideⁱPRO_0000042889	70 – 89	Neuropeptide SAdd BLAST	20

Keywords - PTMⁱ

Cleavage on pair of basic residues

Proteomic databases

PaxDbⁱ	P0C0P6
PeptideAtlas More...PeptideAtlasⁱ	P0C0P6
PRIDEⁱ	P0C0P6
ProteomicsDBⁱ	52294

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000214285
CleanExⁱ	HS_NPS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB020139

HPAⁱ

CAB020139

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	P0C0P6, 1 interactor
STRINGⁱ	9606.ENSP00000381105

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0C0P6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J45R Eukaryota ENOG41115PF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00400000024769
HOGENOMⁱ	HOG000113845
HOVERGENⁱ	HBG082056
InParanoidⁱ	P0C0P6
OMAⁱ	MKRSFRN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14R3
PhylomeDBⁱ	P0C0P6

Family and domain databases

InterProⁱ	View protein in InterPro IPR028138 Neuropeptide_S
PANTHERⁱ	PTHR36679 PTHR36679, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14993 Neuropeptide_S, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P0C0P6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD 
        60         70         80 
RSKELAFLKP ILEKMFVKRS FRNGVGTGMK KTSFQRAKS

Length:89

Mass (Da):10,103

Last modified:November 22, 2005 - v1

Checksum:ⁱ41574555F540A7A4

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051239	14	S → L. Corresponds to variant dbSNP:rs990310Ensembl.		1
Natural variantⁱVAR_051240	75	V → L. Corresponds to variant dbSNP:rs4751440Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BD168686 mRNA No translation available. AL355316 Genomic DNA No translation available. BC148465 mRNA Translation: AAI48466.1 BC156665 mRNA Translation: AAI56666.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41577.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001025184.1, NM_001030013.1
UniGeneⁱ	Hs.643423

Genome annotation databases

Ensemblⁱ	ENST00000398023; ENSP00000381105; ENSG00000214285
GeneIDⁱ	594857
KEGGⁱ	hsa:594857
UCSC genome browser More...UCSCⁱ	uc001ljx.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P0C0P6	NPS isoform 1		PANTR		89
NPS isoform 1		PONAB		89
Neuropeptide S		SAIBB		89
Uncharacterized protein (Fragment)		MACMU		89
Neuropeptide S		COLAP		89
+13

Protein	Similar proteins		Species	Score	Length
P0C0P6	Neuropeptide S		MACNE		89
Neuropeptide S		NOMLE		89
Neuropeptide S		RHIRO		89
Neuropeptide S		RHIBE		89
NPS isoform 1		PONAB		89
+39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BD168686 mRNA No translation available. AL355316 Genomic DNA No translation available. BC148465 mRNA Translation: AAI48466.1 BC156665 mRNA Translation: AAI56666.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41577.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001025184.1, NM_001030013.1
UniGeneⁱ	Hs.643423

3D structure databases

ProteinModelPortalⁱ	P0C0P6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P0C0P6, 1 interactor
STRINGⁱ	9606.ENSP00000381105

Chemistry databases

ChEMBLⁱ	CHEMBL3596086

ChEMBLⁱ

CHEMBL3596086

Polymorphism and mutation databases

BioMutaⁱ	NPS

BioMutaⁱ

NPS

Proteomic databases

PaxDbⁱ	P0C0P6
PeptideAtlas More...PeptideAtlasⁱ	P0C0P6
PRIDEⁱ	P0C0P6
ProteomicsDBⁱ	52294

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	594857
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000398023; ENSP00000381105; ENSG00000214285
GeneIDⁱ	594857
KEGGⁱ	hsa:594857
UCSC genome browser More...UCSCⁱ	uc001ljx.2 human

Organism-specific databases

CTDⁱ	594857
DisGeNET More...DisGeNETⁱ	594857
EuPathDBⁱ	HostDB:ENSG00000214285.2
GeneCardsⁱ	NPS
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33940 NPS
Human Protein Atlas More...HPAⁱ	CAB020139
MIMⁱ	609513 gene
neXtProtⁱ	NX_P0C0P6
Open Targets More...OpenTargetsⁱ	ENSG00000214285
PharmGKBⁱ	PA162398160
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J45R Eukaryota ENOG41115PF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00400000024769
HOGENOMⁱ	HOG000113845
HOVERGENⁱ	HBG082056
InParanoidⁱ	P0C0P6
OMAⁱ	MKRSFRN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14R3
PhylomeDBⁱ	P0C0P6

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiⁱ	Neuropeptide_S
GenomeRNAiⁱ	594857
Protein Ontology More...PROⁱ	PR:P0C0P6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000214285
CleanExⁱ	HS_NPS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028138 Neuropeptide_S
PANTHERⁱ	PTHR36679 PTHR36679, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14993 Neuropeptide_S, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NPS_HUMAN
Accessionⁱ	P0C0P6Primary (citable) accession number: P0C0P6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
	Last sequence update:	November 22, 2005
	Last modified:	June 20, 2018
	This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0C0P6 (NPS_HUMAN)

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Neuropeptide S

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ