UniProtKB - P0C0P6 (NPS_HUMAN)
Protein
Neuropeptide S
Gene
NPS
Organism
Homo sapiens (Human)
Status
Functioni
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).By similarity2 Publications
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- neuropeptide signaling pathway Source: UniProtKB-KW
- positive regulation of action potential Source: GO_Central
- positive regulation of circadian sleep/wake cycle, wakefulness Source: Ensembl
- positive regulation of synaptic transmission, GABAergic Source: GO_Central
- positive regulation of synaptic transmission, glutamatergic Source: GO_Central
- visual learning Source: Ensembl
Keywordsi
Molecular function | Neuropeptide |
Enzyme and pathway databases
PathwayCommonsi | P0C0P6 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Names & Taxonomyi
Protein namesi | Recommended name: Neuropeptide S |
Gene namesi | Name:NPS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33940, NPS |
MIMi | 609513, gene |
neXtProti | NX_P0C0P6 |
VEuPathDBi | HostDB:ENSG00000214285.2 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 594857 |
OpenTargetsi | ENSG00000214285 |
PharmGKBi | PA162398160 |
Miscellaneous databases
Pharosi | P0C0P6, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3596086 |
Genetic variation databases
BioMutai | NPS |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000042888 | 24 – 67 | Add BLAST | 44 | |
PeptideiPRO_0000042889 | 70 – 89 | Neuropeptide SAdd BLAST | 20 |
Keywords - PTMi
Cleavage on pair of basic residuesProteomic databases
PaxDbi | P0C0P6 |
PeptideAtlasi | P0C0P6 |
PRIDEi | P0C0P6 |
ProteomicsDBi | 52294 |
Expressioni
Gene expression databases
Bgeei | ENSG00000214285, Expressed in hypothalamus and 44 other tissues |
Organism-specific databases
HPAi | ENSG00000214285, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
IntActi | P0C0P6, 1 interactor |
STRINGi | 9606.ENSP00000381105 |
Miscellaneous databases
RNActi | P0C0P6, protein |
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SSTA, Eukaryota |
GeneTreei | ENSGT00400000024769 |
HOGENOMi | CLU_2432613_0_0_1 |
InParanoidi | P0C0P6 |
OMAi | FMKRSFR |
OrthoDBi | 1613904at2759 |
PhylomeDBi | P0C0P6 |
Family and domain databases
InterProi | View protein in InterPro IPR028138, Neuropeptide_S |
PANTHERi | PTHR36679, PTHR36679, 1 hit |
Pfami | View protein in Pfam PF14993, Neuropeptide_S, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0C0P6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD
60 70 80
RSKELAFLKP ILEKMFVKRS FRNGVGTGMK KTSFQRAKS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051239 | 14 | S → L. Corresponds to variant dbSNP:rs990310Ensembl. | 1 | |
Natural variantiVAR_051240 | 75 | V → L. Corresponds to variant dbSNP:rs4751440Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BD168686 mRNA No translation available. AL355316 Genomic DNA No translation available. BC148465 mRNA Translation: AAI48466.1 BC156665 mRNA Translation: AAI56666.1 |
CCDSi | CCDS41577.1 |
RefSeqi | NP_001025184.1, NM_001030013.1 |
Genome annotation databases
Ensembli | ENST00000398023; ENSP00000381105; ENSG00000214285 |
GeneIDi | 594857 |
KEGGi | hsa:594857 |
UCSCi | uc001ljx.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BD168686 mRNA No translation available. AL355316 Genomic DNA No translation available. BC148465 mRNA Translation: AAI48466.1 BC156665 mRNA Translation: AAI56666.1 |
CCDSi | CCDS41577.1 |
RefSeqi | NP_001025184.1, NM_001030013.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P0C0P6, 1 interactor |
STRINGi | 9606.ENSP00000381105 |
Chemistry databases
ChEMBLi | CHEMBL3596086 |
Genetic variation databases
BioMutai | NPS |
Proteomic databases
PaxDbi | P0C0P6 |
PeptideAtlasi | P0C0P6 |
PRIDEi | P0C0P6 |
ProteomicsDBi | 52294 |
Protocols and materials databases
Antibodypediai | 57702, 132 antibodies |
DNASUi | 594857 |
Genome annotation databases
Ensembli | ENST00000398023; ENSP00000381105; ENSG00000214285 |
GeneIDi | 594857 |
KEGGi | hsa:594857 |
UCSCi | uc001ljx.2, human |
Organism-specific databases
CTDi | 594857 |
DisGeNETi | 594857 |
GeneCardsi | NPS |
HGNCi | HGNC:33940, NPS |
HPAi | ENSG00000214285, Tissue enhanced (brain) |
MIMi | 609513, gene |
neXtProti | NX_P0C0P6 |
OpenTargetsi | ENSG00000214285 |
PharmGKBi | PA162398160 |
VEuPathDBi | HostDB:ENSG00000214285.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SSTA, Eukaryota |
GeneTreei | ENSGT00400000024769 |
HOGENOMi | CLU_2432613_0_0_1 |
InParanoidi | P0C0P6 |
OMAi | FMKRSFR |
OrthoDBi | 1613904at2759 |
PhylomeDBi | P0C0P6 |
Enzyme and pathway databases
PathwayCommonsi | P0C0P6 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Miscellaneous databases
BioGRID-ORCSi | 594857, 6 hits in 850 CRISPR screens |
GeneWikii | Neuropeptide_S |
GenomeRNAii | 594857 |
Pharosi | P0C0P6, Tbio |
PROi | PR:P0C0P6 |
RNActi | P0C0P6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000214285, Expressed in hypothalamus and 44 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR028138, Neuropeptide_S |
PANTHERi | PTHR36679, PTHR36679, 1 hit |
Pfami | View protein in Pfam PF14993, Neuropeptide_S, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NPS_HUMAN | |
Accessioni | P0C0P6Primary (citable) accession number: P0C0P6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 22, 2005 | |
Last modified: | February 10, 2021 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot