UniProtKB - P0C0L9 (ISCX_ECOLI)
Protein
Protein IscX
Gene
iscX
Organism
Escherichia coli (strain K12)
Status
Functioni
May function as iron donor in the assembly of iron-sulfur clusters.
GO - Molecular functioni
- enzyme inhibitor activity Source: EcoCyc
- ferrous iron binding Source: EcoCyc
- iron ion binding Source: EcoCyc
GO - Biological processi
- iron-sulfur cluster assembly Source: EcoCyc
Enzyme and pathway databases
BioCyci | EcoCyc:EG12311-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Protein IscX |
Gene namesi | Name:iscX Synonyms:yfhJ Ordered Locus Names:b2524, JW2508 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211853 | 1 – 66 | Protein IscXAdd BLAST | 66 |
Proteomic databases
jPOSTi | P0C0L9 |
PaxDbi | P0C0L9 |
PRIDEi | P0C0L9 |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4260583, 9 interactors |
DIPi | DIP-48188N |
IntActi | P0C0L9, 5 interactors |
STRINGi | 511145.b2524 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P0C0L9 |
SMRi | P0C0L9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0C0L9 |
Family & Domainsi
Sequence similaritiesi
Belongs to the IscX family.Curated
Phylogenomic databases
eggNOGi | COG2975, Bacteria |
HOGENOMi | CLU_168040_1_0_6 |
InParanoidi | P0C0L9 |
PhylomeDBi | P0C0L9 |
Family and domain databases
Gene3Di | 1.10.10.600, 1 hit |
InterProi | View protein in InterPro IPR007479, ISC_FeS_clus_asmbl_IscsX IPR036762, IscX-like_sf |
PANTHERi | PTHR37532, PTHR37532, 1 hit |
Pfami | View protein in Pfam PF04384, Fe-S_assembly, 1 hit |
PIRSFi | PIRSF039003, IscX, 1 hit |
SUPFAMi | SSF140319, SSF140319, 1 hit |
TIGRFAMsi | TIGR03412, iscX_yfhJ, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C0L9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLKWTDSRE IGEALYDAYP DLDPKTVRFT DMHQWICDLE DFDDDPQASN
60
EKILEAILLV WLDEAE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 43 – 51 | DDDPQASNE → RTDPGIPTK (PubMed:8300516).Curated | 9 | |
Sequence conflicti | 55 | E → R (PubMed:8300516).Curated | 1 | |
Sequence conflicti | 58 – 66 | LLVWLDEAE → C (PubMed:8300516).Curated | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88654 Genomic DNA No translation available. U01827 Unassigned DNA No translation available. U00096 Genomic DNA Translation: AAC75577.1 AP009048 Genomic DNA Translation: BAA16414.1 |
PIRi | C65029 |
RefSeqi | NP_417019.1, NC_000913.3 WP_000523616.1, NZ_STEB01000011.1 |
Genome annotation databases
EnsemblBacteriai | AAC75577; AAC75577; b2524 BAA16414; BAA16414; BAA16414 |
GeneIDi | 58460724 945196 |
KEGGi | ecj:JW2508 eco:b2524 |
PATRICi | fig|1411691.4.peg.4210 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88654 Genomic DNA No translation available. U01827 Unassigned DNA No translation available. U00096 Genomic DNA Translation: AAC75577.1 AP009048 Genomic DNA Translation: BAA16414.1 |
PIRi | C65029 |
RefSeqi | NP_417019.1, NC_000913.3 WP_000523616.1, NZ_STEB01000011.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UJ8 | X-ray | 1.75 | A | 2-66 | [»] | |
2BZT | NMR | - | A | 1-66 | [»] | |
BMRBi | P0C0L9 | |||||
SMRi | P0C0L9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260583, 9 interactors |
DIPi | DIP-48188N |
IntActi | P0C0L9, 5 interactors |
STRINGi | 511145.b2524 |
Proteomic databases
jPOSTi | P0C0L9 |
PaxDbi | P0C0L9 |
PRIDEi | P0C0L9 |
Genome annotation databases
EnsemblBacteriai | AAC75577; AAC75577; b2524 BAA16414; BAA16414; BAA16414 |
GeneIDi | 58460724 945196 |
KEGGi | ecj:JW2508 eco:b2524 |
PATRICi | fig|1411691.4.peg.4210 |
Organism-specific databases
EchoBASEi | EB2217 |
Phylogenomic databases
eggNOGi | COG2975, Bacteria |
HOGENOMi | CLU_168040_1_0_6 |
InParanoidi | P0C0L9 |
PhylomeDBi | P0C0L9 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12311-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0C0L9 |
PROi | PR:P0C0L9 |
Family and domain databases
Gene3Di | 1.10.10.600, 1 hit |
InterProi | View protein in InterPro IPR007479, ISC_FeS_clus_asmbl_IscsX IPR036762, IscX-like_sf |
PANTHERi | PTHR37532, PTHR37532, 1 hit |
Pfami | View protein in Pfam PF04384, Fe-S_assembly, 1 hit |
PIRSFi | PIRSF039003, IscX, 1 hit |
SUPFAMi | SSF140319, SSF140319, 1 hit |
TIGRFAMsi | TIGR03412, iscX_yfhJ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ISCX_ECOLI | |
Accessioni | P0C0L9Primary (citable) accession number: P0C0L9 Secondary accession number(s): P37096 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 22, 2005 | |
Last modified: | April 7, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families