UniProtKB - P0C0L2 (OSMC_ECOLI)
Protein
Peroxiredoxin OsmC
Gene
osmC
Organism
Escherichia coli (strain K12)
Status
Functioni
Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide.1 Publication
Catalytic activityi
GO - Molecular functioni
- peroxidase activity Source: EcoCyc
- peroxiredoxin activity Source: EcoCyc
GO - Biological processi
- hyperosmotic response Source: EcoCyc
- response to hydroperoxide Source: EcoCyc
- response to oxidative stress Source: EcoCyc
Keywordsi
Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10680-MONOMER MetaCyc:EG10680-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxiredoxin OsmC (EC:1.11.1.-)Alternative name(s): Osmotically-inducible protein C |
Gene namesi | Name:osmC Ordered Locus Names:b1482, JW1477 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- cytosol Source: EcoCyc
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000172729 | 2 – 143 | Peroxiredoxin OsmCAdd BLAST | 142 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | N6-acetyllysine1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P0C0L2 |
PaxDbi | P0C0L2 |
PRIDEi | P0C0L2 |
PTM databases
iPTMneti | P0C0L2 |
Expressioni
Inductioni
By elevated osmotic pressure in the growth medium.
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260206, 234 interactors 850404, 3 interactors |
DIPi | DIP-48058N |
IntActi | P0C0L2, 11 interactors |
STRINGi | 511145.b1482 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0C0L2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0C0L2 |
Family & Domainsi
Sequence similaritiesi
Belongs to the OsmC/Ohr family.Curated
Phylogenomic databases
eggNOGi | COG1764, Bacteria |
HOGENOMi | CLU_106355_1_0_6 |
InParanoidi | P0C0L2 |
PhylomeDBi | P0C0L2 |
Family and domain databases
Gene3Di | 3.30.300.20, 1 hit |
InterProi | View protein in InterPro IPR015946, KH_dom-like_a/b IPR003718, OsmC/Ohr_fam IPR036102, OsmC/Ohrsf IPR019904, Peroxiredoxin_OsmC |
Pfami | View protein in Pfam PF02566, OsmC, 1 hit |
SUPFAMi | SSF82784, SSF82784, 1 hit |
TIGRFAMsi | TIGR03562, osmo_induc_OsmC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0C0L2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTIHKKGQAH WEGDIKRGKG TVSTESGVLN QQPYGFNTRF EGEKGTNPEE
60 70 80 90 100
LIGAAHAACF SMALSLMLGE AGFTPTSIDT TADVSLDKVD AGFAITKIAL
110 120 130 140
KSEVAVPGID ASTFDGIIQK AKAGCPVSQV LKAEITLDYQ LKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57433 Genomic DNA Translation: CAA40680.1 U00096 Genomic DNA Translation: AAC74555.1 AP009048 Genomic DNA Translation: BAA15128.1 |
PIRi | E64901 |
RefSeqi | NP_415999.1, NC_000913.3 WP_000152305.1, NZ_STEB01000054.1 |
Genome annotation databases
EnsemblBacteriai | AAC74555; AAC74555; b1482 BAA15128; BAA15128; BAA15128 |
GeneIDi | 48105731 946043 |
KEGGi | ecj:JW1477 eco:b1482 |
PATRICi | fig|1411691.4.peg.785 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57433 Genomic DNA Translation: CAA40680.1 U00096 Genomic DNA Translation: AAC74555.1 AP009048 Genomic DNA Translation: BAA15128.1 |
PIRi | E64901 |
RefSeqi | NP_415999.1, NC_000913.3 WP_000152305.1, NZ_STEB01000054.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NYE | X-ray | 2.40 | A/B/C/D/E/F | 1-143 | [»] | |
1QWI | X-ray | 1.80 | A/B/C/D | 1-143 | [»] | |
SMRi | P0C0L2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260206, 234 interactors 850404, 3 interactors |
DIPi | DIP-48058N |
IntActi | P0C0L2, 11 interactors |
STRINGi | 511145.b1482 |
PTM databases
iPTMneti | P0C0L2 |
Proteomic databases
jPOSTi | P0C0L2 |
PaxDbi | P0C0L2 |
PRIDEi | P0C0L2 |
Protocols and materials databases
DNASUi | 946043 |
Genome annotation databases
EnsemblBacteriai | AAC74555; AAC74555; b1482 BAA15128; BAA15128; BAA15128 |
GeneIDi | 48105731 946043 |
KEGGi | ecj:JW1477 eco:b1482 |
PATRICi | fig|1411691.4.peg.785 |
Organism-specific databases
EchoBASEi | EB0674 |
Phylogenomic databases
eggNOGi | COG1764, Bacteria |
HOGENOMi | CLU_106355_1_0_6 |
InParanoidi | P0C0L2 |
PhylomeDBi | P0C0L2 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10680-MONOMER MetaCyc:EG10680-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P0C0L2 |
PROi | PR:P0C0L2 |
Family and domain databases
Gene3Di | 3.30.300.20, 1 hit |
InterProi | View protein in InterPro IPR015946, KH_dom-like_a/b IPR003718, OsmC/Ohr_fam IPR036102, OsmC/Ohrsf IPR019904, Peroxiredoxin_OsmC |
Pfami | View protein in Pfam PF02566, OsmC, 1 hit |
SUPFAMi | SSF82784, SSF82784, 1 hit |
TIGRFAMsi | TIGR03562, osmo_induc_OsmC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OSMC_ECOLI | |
Accessioni | P0C0L2Primary (citable) accession number: P0C0L2 Secondary accession number(s): P23929, P77655 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families