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Protein

Ephrin type-B receptor 6

Gene

EPHB6

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi675 – 683ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionReceptor
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-B receptor 6
Alternative name(s):
Tyrosine-protein kinase-defective receptor EPH-6
Gene namesi
Name:EPHB6
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 597ExtracellularSequence analysisAdd BLAST566
Transmembranei598 – 618HelicalSequence analysisAdd BLAST21
Topological domaini619 – 1020CytoplasmicSequence analysisAdd BLAST402

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000004211232 – 1020Ephrin type-B receptor 6Add BLAST989

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0C0K6
PRIDEiP0C0K6

Interactioni

Subunit structurei

Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner (By similarity).By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000033908

Structurei

3D structure databases

SMRiP0C0K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 236Eph LBDPROSITE-ProRule annotationAdd BLAST204
Domaini368 – 485Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST118
Domaini486 – 581Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini669 – 918Protein kinasePROSITE-ProRule annotationAdd BLAST250
Domaini947 – 1011SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1018 – 1020PDZ-bindingSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi166 – 175Poly-Ser10
Compositional biasi218 – 365Cys-richAdd BLAST148
Compositional biasi880 – 883Poly-Pro4

Domaini

The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2 (By similarity).PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233856
HOVERGENiHBG062180
InParanoidiP0C0K6

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P0C0K6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATEGAAQLG NRVAGMVCSL WVLLLVSSVL ALEEVLLDTT GETSEIGWLT
60 70 80 90 100
YPPGGWDEVS VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVERRGA
110 120 130 140 150
QRAHIRLHFS VRACSSLGVS GGTCRETFTL YYRQAEEPDS PDSVSSWHLK
160 170 180 190 200
RWTKVDTIAA DESFPSSSSS SSSSSAAWAV GPHGAGQRAG LQLNVKERSF
210 220 230 240 250
GPLTQRGFYV AFQDTGACLA LVAVRLFSYT CPAVLRSFAS FPETQASGAG
260 270 280 290 300
GASLVAAVGT CVAHAEPEED GVGGQAGGSP PRLHCNGEGK WMVAVGGCRC
310 320 330 340 350
QPGYQPARGD KACQACPRGL YKASAGNAPC SPCPARSHAA NPAAPVCPCL
360 370 380 390 400
EGFYRASSDP PEAPCTGPPS APQELWFEVQ GSALMLHWRL PRELGGRGDL
410 420 430 440 450
LFNVVCKECE GRQEPASGGG GTCRRCRDEV HFDPRQRGLT ESRVLVGGLR
460 470 480 490 500
AHVPYILEVQ AVNGVSELSP DPPQAAAINV STSHEVPSAV PVVHQVSRAS
510 520 530 540 550
NSITVSWPQP DQTNGNILDY QLRYYDQVED ESHSFTLTSE TNTATVTQLS
560 570 580 590 600
PGHIYGFQVR ARTAAGHGPY GGKVYFQTLP QGELSSQLPE RLSLVIGSIL
610 620 630 640 650
GALAFLLLAA ITVLAVVFQR KRRGTGYTEQ LQQYSSPGLG VKYYIDPSTY
660 670 680 690 700
EDPCQAIREL AREVDPAYIK IEEVIGTGSF GEVRRGRLQP RGRREQTVAI
710 720 730 740 750
QALWAGGAES LQMTFLGRAA VLGQFQHPNI LRLEGVVTKS RPLMVLTEFM
760 770 780 790 800
ELGPLDSFLR QREGQFSSLQ LVAMQRGVAA AMQYLSSFAF VHRSLSAHSV
810 820 830 840 850
LVNSHLVCKV ARLGHSPQGP SCLLRWAAPE VIAHGKHTTS SDVWSFGILM
860 870 880 890 900
WEVMSYGERP YWDMSEQEVL NAIEQEFRLP PPPGCPPGLH LLMLDTWQKD
910 920 930 940 950
RARRPHFDQL VAAFDKMIRK PDTLQACGDP GERPSQALLT PVALDFPCLD
960 970 980 990 1000
SPQAWLSAIG LECYQDNFSK FGLCTFSDVA QLSLEDLPAL GITLAGHQKK
1010 1020
LLHHIQLLQQ HLRQQGSVEV
Length:1,020
Mass (Da):110,692
Last modified:April 20, 2010 - v4
Checksum:iA3E63E2DF11BEEC5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2QVJ1H2QVJ1_PANTR
EPH receptor B6
EPHB6 CK820_G0014105
1,020Annotation score:
A0A2I3SFW2A0A2I3SFW2_PANTR
EPHB6 isoform 5
EPHB6 CK820_G0014105
183Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADA01063189 Genomic DNA No translation available.
AADA01251555 Genomic DNA No translation available.

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADA01063189 Genomic DNA No translation available.
AADA01251555 Genomic DNA No translation available.

3D structure databases

SMRiP0C0K6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000033908

Proteomic databases

PaxDbiP0C0K6
PRIDEiP0C0K6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233856
HOVERGENiHBG062180
InParanoidiP0C0K6

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEPHB6_PANTR
AccessioniPrimary (citable) accession number: P0C0K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 79 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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