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Entry version 78 (22 Apr 2020)
Sequence version 1 (13 Sep 2005)
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Protein

Streptopain

Gene

speB

Organism
Streptococcus pyogenes
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Preferential cleavage with hydrophobic residues at P2, P1 and P1'. EC:3.4.22.10

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei192Nucleophile1 Publication1
Active sitei340Proton acceptor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • pathogenesis Source: UniProtKB-KW
  • proteolysis in other organism Source: CACAO

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease, Toxin
Biological processVirulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_000468795-HMP:HMPREF1231_2014-MONOMER
GCF_000483565-HMP:HMPREF1236_RS05775-MONOMER
GCF_000483625-HMP:HMPREF1239_RS00080-MONOMER
GCF_000499145-HMP:HMPREF1243_RS06705-MONOMER
GCF_000499265-HMP:HMPREF1244_RS00550-MONOMER
SPYO1010840:G1H3G-1637-MONOMER
SPYO1336746:G1HIJ-1739-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.10 5935

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P0C0J0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Streptopain (EC:3.4.22.10)
Alternative name(s):
Exotoxin type B
SPE B
Streptococcal cysteine proteinase
Streptococcus peptidase A
Short name:
SPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:speB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pyogenes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1314 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...
PHI-basei
PHI:5437
PHI:7040

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2034806

Drug and drug target database

More...
DrugBanki
DB02766 N-[(2R)-4-diazonio-3-oxoniumylidene-1-phenylbutan-2-yl]-1-phenylmethoxymethanimidate

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 271 PublicationAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002850328 – 1451 PublicationAdd BLAST118
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000028504146 – 398StreptopainAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei192Cysteine methyl disulfide; in zymogen form1 Publication1

Keywords - PTMi

Methylation, Zymogen

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1314.HKU360_01851

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P0C0J0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C0J0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P0C0J0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105JBQ Bacteria
ENOG4111S8V LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR000200 Peptidase_C10
IPR025896 Spi_Prtas-inh

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13734 Inhibitor_I69, 1 hit
PF01640 Peptidase_C10, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00797 STREPTOPAIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKKKLGIRL LSLLALGGFV LANPVFADQN FARNEKEAKD SAITFIQKSA
60 70 80 90 100
AIKAGARSAE DIKLDKVNLG GELSGSNMYV YNISTGGFVI VSGDKRSPEI
110 120 130 140 150
LGYSTSGSFD ANGKENIASF MESYVEQIKE NKKLDTTYAG TAEIKQPVVK
160 170 180 190 200
SLLDSKGIHY NQGNPYNLLT PVIEKVKPGE QSFVGQHAAT GCVATATAQI
210 220 230 240 250
MKYHNYPNKG LKDYTYTLSS NNPYFNHPKN LFAAISTRQY NWNNILPTYS
260 270 280 290 300
GRESNVQKMA ISELMADVGI SVDMDYGPSS GSAGSSRVQR ALKENFGYNQ
310 320 330 340 350
SVHQINRSDF SKQDWEAQID KELSQNQPVY YQGVGKVGGH AFVIDGADGR
360 370 380 390
NFYHVNWGWG GVSDGFFRLD ALNPSALGTG GGAGGFNGYQ SAVVGIKP
Length:398
Mass (Da):43,174
Last modified:September 13, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16FF180D720AEE0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84 – 85ST → AS AA sequence (Ref. 4) Curated2
Sequence conflicti169L → I AA sequence (Ref. 4) Curated1
Sequence conflicti187 – 191HAATG → AATGH AA sequence (Ref. 4) Curated5
Sequence conflicti187 – 191HAATG → AATGH AA sequence (PubMed:1270417).Curated5
Sequence conflicti208N → D AA sequence (Ref. 4) Curated1
Sequence conflicti208N → D AA sequence (PubMed:1270417).Curated1
Sequence conflicti213D → N AA sequence (Ref. 4) Curated1
Sequence conflicti213D → N AA sequence (PubMed:1270417).Curated1
Sequence conflicti222 – 223NP → PD AA sequence (Ref. 4) Curated2
Sequence conflicti222 – 223NP → PD AA sequence (PubMed:1270417).Curated2
Sequence conflicti226N → D AA sequence (Ref. 4) Curated1
Sequence conflicti226N → D AA sequence (PubMed:1270417).Curated1
Sequence conflicti241N → D AA sequence (Ref. 4) Curated1
Sequence conflicti241N → D AA sequence (PubMed:1270417).Curated1
Sequence conflicti253 – 257ESNVQ → QSQNV AA sequence (Ref. 4) Curated5
Sequence conflicti253 – 257ESNVQ → QSQNV AA sequence (PubMed:1270417).Curated5
Sequence conflicti306N → D AA sequence (Ref. 4) Curated1
Sequence conflicti332Q → E AA sequence (Ref. 4) Curated1
Sequence conflicti332Q → E AA sequence (PubMed:1270417).Curated1
Sequence conflicti346 – 348GAD → DGA AA sequence (Ref. 4) Curated3
Sequence conflicti346 – 348GAD → DGA AA sequence (PubMed:1270417).Curated3
Sequence conflicti356N → D AA sequence (Ref. 4) Curated1
Sequence conflicti356N → D AA sequence (PubMed:1270417).Curated1
Sequence conflicti390Q → E AA sequence (Ref. 4) Curated1
Sequence conflicti390Q → E AA sequence (PubMed:1270417).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti17G → S in strain: MGAS 1896. 1
Natural varianti80V → I in strain: MGAS 168. 1
Natural varianti111A → V in strain: MGAS 165, 168, 429, 659, 660, 796, 800, 1719, 1838, 1882, 2017 and 2018. 1
Natural varianti137T → I in strain: MGAS 650. 1
Natural varianti154D → N in strain: MGAS 684. 1
Natural varianti211L → V in strain: MGAS 366, 427, 758, 1294, 1911, 1914A and 1991. 1
Natural varianti305I → V in strain: MGAS 1901 and Sv. 1
Natural varianti308S → G in strain: MGAS 429, 659, 807, 1226, 1719, 1832, 1842, 1871, 1872, 2017 and 2018. 1
Natural varianti317A → S in strain: MGAS 165, 168, 289, 302, 1233 and 1898. 1
Natural varianti384G → D in strain: MGAS 1871. 1
Natural varianti394V → I in strain: MGAS 366 and 1294. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M86905 Genomic DNA Translation: AAA26978.1
L26126 Genomic DNA Translation: AAA26992.1
L26127 Genomic DNA Translation: AAA26993.1
L26128 Genomic DNA Translation: AAA26994.1
L26129 Genomic DNA Translation: AAA26995.1
L26130 Genomic DNA Translation: AAA26996.1
L26131 Genomic DNA Translation: AAA26997.1
L26132 Genomic DNA Translation: AAA26998.1
L26133 Genomic DNA Translation: AAA26999.1
L26135 Genomic DNA Translation: AAA27001.1
L26136 Genomic DNA Translation: AAA27002.1
L26137 Genomic DNA Translation: AAA27003.1
L26138 Genomic DNA Translation: AAA27004.1
L26139 Genomic DNA Translation: AAA27005.1
L26140 Genomic DNA Translation: AAA27006.1
L26141 Genomic DNA Translation: AAA27007.1
L26142 Genomic DNA Translation: AAA27008.1
L26143 Genomic DNA Translation: AAA27009.1
L26144 Genomic DNA Translation: AAA27010.1
L26145 Genomic DNA Translation: AAA27011.1
L26147 Genomic DNA Translation: AAA27013.1
L26148 Genomic DNA Translation: AAA27014.1
L26149 Genomic DNA Translation: AAA27015.1
L26150 Genomic DNA Translation: AAA27016.1
L26151 Genomic DNA Translation: AAA26980.1
L26152 Genomic DNA Translation: AAA26981.1
L26153 Genomic DNA Translation: AAA26982.1
L26154 Genomic DNA Translation: AAA26983.1
L26155 Genomic DNA Translation: AAA26984.1
L26156 Genomic DNA Translation: AAA26985.1
L26157 Genomic DNA Translation: AAA26986.1
L26159 Genomic DNA Translation: AAA26988.1
L26160 Genomic DNA Translation: AAA26989.1
L26161 Genomic DNA Translation: AAA26990.1
L26162 Genomic DNA Translation: AAA26991.1
AB030578 Genomic DNA Translation: BAB16027.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A37768

NCBI Reference Sequences

More...
RefSeqi
WP_002982421.1, NZ_UHHE01000001.1
WP_002991253.1, NZ_WBMD01000004.1
WP_009881074.1, NZ_SJKX01000007.1
WP_011285235.1, NZ_UHHJ01000005.1
WP_014407896.1, NZ_UHHN01000001.1
WP_021733538.1, NZ_QFXT01000046.1
WP_023611203.1, NZ_LS483336.1
WP_031488619.1, NZ_SJLK01000002.1
WP_038433740.1, NZ_LS483353.1
WP_076639504.1, NZ_UHHK01000003.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86905 Genomic DNA Translation: AAA26978.1
L26126 Genomic DNA Translation: AAA26992.1
L26127 Genomic DNA Translation: AAA26993.1
L26128 Genomic DNA Translation: AAA26994.1
L26129 Genomic DNA Translation: AAA26995.1
L26130 Genomic DNA Translation: AAA26996.1
L26131 Genomic DNA Translation: AAA26997.1
L26132 Genomic DNA Translation: AAA26998.1
L26133 Genomic DNA Translation: AAA26999.1
L26135 Genomic DNA Translation: AAA27001.1
L26136 Genomic DNA Translation: AAA27002.1
L26137 Genomic DNA Translation: AAA27003.1
L26138 Genomic DNA Translation: AAA27004.1
L26139 Genomic DNA Translation: AAA27005.1
L26140 Genomic DNA Translation: AAA27006.1
L26141 Genomic DNA Translation: AAA27007.1
L26142 Genomic DNA Translation: AAA27008.1
L26143 Genomic DNA Translation: AAA27009.1
L26144 Genomic DNA Translation: AAA27010.1
L26145 Genomic DNA Translation: AAA27011.1
L26147 Genomic DNA Translation: AAA27013.1
L26148 Genomic DNA Translation: AAA27014.1
L26149 Genomic DNA Translation: AAA27015.1
L26150 Genomic DNA Translation: AAA27016.1
L26151 Genomic DNA Translation: AAA26980.1
L26152 Genomic DNA Translation: AAA26981.1
L26153 Genomic DNA Translation: AAA26982.1
L26154 Genomic DNA Translation: AAA26983.1
L26155 Genomic DNA Translation: AAA26984.1
L26156 Genomic DNA Translation: AAA26985.1
L26157 Genomic DNA Translation: AAA26986.1
L26159 Genomic DNA Translation: AAA26988.1
L26160 Genomic DNA Translation: AAA26989.1
L26161 Genomic DNA Translation: AAA26990.1
L26162 Genomic DNA Translation: AAA26991.1
AB030578 Genomic DNA Translation: BAB16027.1
PIRiA37768
RefSeqiWP_002982421.1, NZ_UHHE01000001.1
WP_002991253.1, NZ_WBMD01000004.1
WP_009881074.1, NZ_SJKX01000007.1
WP_011285235.1, NZ_UHHJ01000005.1
WP_014407896.1, NZ_UHHN01000001.1
WP_021733538.1, NZ_QFXT01000046.1
WP_023611203.1, NZ_LS483336.1
WP_031488619.1, NZ_SJLK01000002.1
WP_038433740.1, NZ_LS483353.1
WP_076639504.1, NZ_UHHK01000003.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DKIX-ray1.60A/B/C/D28-398[»]
1PVJX-ray3.00A/B/C/D31-398[»]
2UZJX-ray1.55A/B146-398[»]
SMRiP0C0J0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi1314.HKU360_01851

Chemistry databases

BindingDBiP0C0J0
ChEMBLiCHEMBL2034806
DrugBankiDB02766 N-[(2R)-4-diazonio-3-oxoniumylidene-1-phenylbutan-2-yl]-1-phenylmethoxymethanimidate

Phylogenomic databases

eggNOGiENOG4105JBQ Bacteria
ENOG4111S8V LUCA

Enzyme and pathway databases

BioCyciGCF_000468795-HMP:HMPREF1231_2014-MONOMER
GCF_000483565-HMP:HMPREF1236_RS05775-MONOMER
GCF_000483625-HMP:HMPREF1239_RS00080-MONOMER
GCF_000499145-HMP:HMPREF1243_RS06705-MONOMER
GCF_000499265-HMP:HMPREF1244_RS00550-MONOMER
SPYO1010840:G1H3G-1637-MONOMER
SPYO1336746:G1HIJ-1739-MONOMER
BRENDAi3.4.22.10 5935
SABIO-RKiP0C0J0

Miscellaneous databases

EvolutionaryTraceiP0C0J0
PHI-baseiPHI:5437
PHI:7040

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR000200 Peptidase_C10
IPR025896 Spi_Prtas-inh
PfamiView protein in Pfam
PF13734 Inhibitor_I69, 1 hit
PF01640 Peptidase_C10, 1 hit
PRINTSiPR00797 STREPTOPAIN
SUPFAMiSSF54001 SSF54001, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPEB_STRPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C0J0
Secondary accession number(s): P00788
, P26296, P68883, Q54960, Q54961, Q54962, Q54963, Q54964, Q54965, Q54966, Q54967, Q54968, Q57024, Q57082, Q57202, Q57211, Q57212, Q9S680
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 13, 2005
Last modified: April 22, 2020
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
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