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Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Streptococcus pyogenes
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 7,8-dihydroneopterin aldolase (SPYOINFP_00405), 7,8-dihydroneopterin aldolase (folB), 7,8-dihydroneopterin aldolase (folB), Dihydroneopterin aldolase (folB), 7,8-dihydroneopterin aldolase (folB), 7,8-dihydroneopterin aldolase (folB)
  4. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00155.

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
OrganismiStreptococcus pyogenes
Taxonomic identifieri1314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682591 – 1662-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd BLAST166

Structurei

3D structure databases

ProteinModelPortaliP0C0G2.
SMRiP0C0G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiENOG4105K8U. Bacteria.
COG0801. LUCA.

Family and domain databases

CDDicd00483. HPPK. 1 hit.
Gene3Di3.30.70.560. 1 hit.
InterProiView protein in InterPro
IPR000550. Hppk.
IPR035907. Hppk_sf.
PfamiView protein in Pfam
PF01288. HPPK. 1 hit.
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiView protein in PROSITE
PS00794. HPPK. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIVYLSLGT NMGDRAAYLQ KALEALADLP QTRLLAQSSI YETTAWGKTG
60 70 80 90 100
QADFLNMACQ LDTQLTAADF LKETQAIEQS LGRVRHEKWG SRTIDIDILL
110 120 130 140 150
FGEEVYDTKE LKVPHPYMTE RAFVLIPLLE LQPDLKLPPN HKFLRDYLAA
160
LDQSDITLFS AQQTEF
Length:166
Mass (Da):18,824
Last modified:September 13, 2005 - v1
Checksum:i5241A1C55BF70A3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312186 Genomic DNA. Translation: CAC39315.1.
AJ000685 Genomic DNA. Translation: CAA04240.1.
RefSeqiWP_002984757.1. NZ_OEIP01000011.1.

Similar proteinsi

Entry informationi

Entry nameiHPPK_STRPY
AccessioniPrimary (citable) accession number: P0C0G2
Secondary accession number(s): O33726
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program