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Protein

Charged multivesicular body protein 6

Gene

Chmp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Charged multivesicular body protein 6
Alternative name(s):
Chromatin-modifying protein 6
Gene namesi
Name:Chmp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3583942 Chmp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002115092 – 200Charged multivesicular body protein 6Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei119PhosphoserineCombined sources1
Modified residuei130PhosphothreonineBy similarity1

Post-translational modificationi

ISGylated in a CHMP5-dependent manner. Isgylation weakens its interaction with VPS4A (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP0C0A3
MaxQBiP0C0A3
PaxDbiP0C0A3
PRIDEiP0C0A3

PTM databases

iPTMnetiP0C0A3
PhosphoSitePlusiP0C0A3

Expressioni

Gene expression databases

BgeeiENSMUSG00000025371 Expressed in 230 organ(s), highest expression level in ear vesicle
CleanExiMM_CHMP6
ExpressionAtlasiP0C0A3 baseline and differential
GenevisibleiP0C0A3 MM

Interactioni

Subunit structurei

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C. Interacts with SNF8, VPS25 and VPS36 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228946, 18 interactors
ComplexPortaliCPX-332 ESCRT-III complex, variant Chmp1b1
CPX-333 ESCRT-III complex, variant Chmp1b2
IntActiP0C0A3, 18 interactors
STRINGi10090.ENSMUSP00000026434

Structurei

3D structure databases

ProteinModelPortaliP0C0A3
SMRiP0C0A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 145Sequence analysisAdd BLAST136

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi168 – 179Type-2 MIT-interacting motifBy similarityAdd BLAST12

Domaini

The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity).By similarity

Sequence similaritiesi

Belongs to the SNF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2910 Eukaryota
ENOG4111HN3 LUCA
GeneTreeiENSGT00720000108863
HOGENOMiHOG000238748
HOVERGENiHBG080510
InParanoidiP0C0A3
KOiK12195
OMAiYQKRITQ
OrthoDBiEOG091G0PBE
PhylomeDBiP0C0A3
TreeFamiTF105929

Family and domain databases

InterProiView protein in InterPro
IPR005024 Snf7_fam
PfamiView protein in Pfam
PF03357 Snf7, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P0C0A3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNLFGRKKQ SRVTEQDRAI LQLKQQRDKL RQYQKRVTQQ LERERALARQ
60 70 80 90 100
LLRDGRKERA KLLLKKKRYR EQLLDRTENQ ISSLEAMVQS IEFTQIEMKV
110 120 130 140 150
MEGLQVGNEC LNKMHQVMSI EEVERILDET QEAVEYQRQI DELLAGNFTQ
160 170 180 190 200
EDEDAILEEL NAITQEQMEL PEVPSEPLPD RNPEAPAKAR SRQAELVAAS
Length:200
Mass (Da):23,416
Last modified:January 23, 2007 - v2
Checksum:i13EE6683997D46C6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AZ42B1AZ42_MOUSE
Charged multivesicular body protein...
Chmp6
78Annotation score:
B1AZ41B1AZ41_MOUSE
Charged multivesicular body protein...
Chmp6
37Annotation score:
B1AZ40B1AZ40_MOUSE
Charged multivesicular body protein...
Chmp6
24Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BI157958 mRNA No translation available.
CCDSiCCDS36385.1
RefSeqiNP_001078967.1, NM_001085498.2
UniGeneiMm.306673

Genome annotation databases

EnsembliENSMUST00000026434; ENSMUSP00000026434; ENSMUSG00000025371
GeneIDi208092
KEGGimmu:208092
UCSCiuc007mrd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BI157958 mRNA No translation available.
CCDSiCCDS36385.1
RefSeqiNP_001078967.1, NM_001085498.2
UniGeneiMm.306673

3D structure databases

ProteinModelPortaliP0C0A3
SMRiP0C0A3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228946, 18 interactors
ComplexPortaliCPX-332 ESCRT-III complex, variant Chmp1b1
CPX-333 ESCRT-III complex, variant Chmp1b2
IntActiP0C0A3, 18 interactors
STRINGi10090.ENSMUSP00000026434

PTM databases

iPTMnetiP0C0A3
PhosphoSitePlusiP0C0A3

Proteomic databases

EPDiP0C0A3
MaxQBiP0C0A3
PaxDbiP0C0A3
PRIDEiP0C0A3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026434; ENSMUSP00000026434; ENSMUSG00000025371
GeneIDi208092
KEGGimmu:208092
UCSCiuc007mrd.2 mouse

Organism-specific databases

CTDi79643
MGIiMGI:3583942 Chmp6

Phylogenomic databases

eggNOGiKOG2910 Eukaryota
ENOG4111HN3 LUCA
GeneTreeiENSGT00720000108863
HOGENOMiHOG000238748
HOVERGENiHBG080510
InParanoidiP0C0A3
KOiK12195
OMAiYQKRITQ
OrthoDBiEOG091G0PBE
PhylomeDBiP0C0A3
TreeFamiTF105929

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

PROiPR:P0C0A3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025371 Expressed in 230 organ(s), highest expression level in ear vesicle
CleanExiMM_CHMP6
ExpressionAtlasiP0C0A3 baseline and differential
GenevisibleiP0C0A3 MM

Family and domain databases

InterProiView protein in InterPro
IPR005024 Snf7_fam
PfamiView protein in Pfam
PF03357 Snf7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHMP6_MOUSE
AccessioniPrimary (citable) accession number: P0C0A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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