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Entry version 103 (13 Feb 2019)
Sequence version 2 (16 Nov 2011)
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Protein

FRAS1-related extracellular matrix protein 3

Gene

FREM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix protein which may play a role in cell adhesion.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: BHF-UCL
  • cell communication Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FRAS1-related extracellular matrix protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FREM3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183090.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25172 FREM3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608946 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0C091

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
166752

Open Targets

More...
OpenTargetsi
ENSG00000183090

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FREM3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
357528797

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001012731 – 2139FRAS1-related extracellular matrix protein 3Add BLAST2109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi846N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1588N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0C091

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0C091

PeptideAtlas

More...
PeptideAtlasi
P0C091

PRoteomics IDEntifications database

More...
PRIDEi
P0C091

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52290

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0C091

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0C091

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183090 Expressed in 64 organ(s), highest expression level in dorsolateral prefrontal cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0C091 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041641

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332886

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P0C091

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C091

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati306 – 409CSPG 1PROSITE-ProRule annotationAdd BLAST104
Repeati432 – 522CSPG 2PROSITE-ProRule annotationAdd BLAST91
Repeati543 – 677CSPG 3PROSITE-ProRule annotationAdd BLAST135
Repeati702 – 807CSPG 4PROSITE-ProRule annotationAdd BLAST106
Repeati828 – 920CSPG 5PROSITE-ProRule annotationAdd BLAST93
Repeati948 – 1040CSPG 6PROSITE-ProRule annotationAdd BLAST93
Repeati1069 – 1171CSPG 7PROSITE-ProRule annotationAdd BLAST103
Repeati1192 – 1285CSPG 8PROSITE-ProRule annotationAdd BLAST94
Repeati1306 – 1404CSPG 9PROSITE-ProRule annotationAdd BLAST99
Repeati1425 – 1516CSPG 10PROSITE-ProRule annotationAdd BLAST92
Repeati1536 – 1625CSPG 11PROSITE-ProRule annotationAdd BLAST90
Repeati1659 – 1756CSPG 12PROSITE-ProRule annotationAdd BLAST98
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1764 – 1862Calx-beta 1Add BLAST99
Domaini1875 – 1985Calx-beta 2Add BLAST111
Domaini2000 – 2106Calx-beta 3Add BLAST107

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRAS1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1306 Eukaryota
KOG3597 Eukaryota
ENOG41112TU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162501

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007464

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081538

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0C091

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLSDGKH

Database of Orthologous Groups

More...
OrthoDBi
13258at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0C091

TreeFam database of animal gene trees

More...
TreeFami
TF316876

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2030, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR039005 CSPG_rpt
IPR032833 FREM3

The PANTHER Classification System

More...
PANTHERi
PTHR11878:SF31 PTHR11878:SF31, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160 Calx-beta, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237 Calx_beta, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072 SSF141072, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854 CSPG, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0C091-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGASRHPTG TPRQLLVALA CLLLSRPALQ GRASSLGTEP DPALYLPARG
60 70 80 90 100
ALDGTRPDGP SVLIANPGLR VPLGRSLWLD PLRDLVIGVQ PGDRCEVTVL
110 120 130 140 150
DALPRLKGAL SPRRFPCTFG PRQVQYTHFG SHSPGRARVL LQLRYDAPTH
160 170 180 190 200
TLVLPFTLAV DLVFSQLELV TRNRPLVVEK LRSWSRAIDR RVLDFASLKS
210 220 230 240 250
GATATRRCRL TPLPHEDGPL PKYGRLVDAV GAPLPRGKGV DCEAFLRAGV
260 270 280 290 300
RYQHTATSSP NRDYVPMMVE LLGPEGQDAG SAGVLVREHF QLLVRIRGGA
310 320 330 340 350
ENTPPRPSFM ATMMMEVDPL VLTALTPDAL AAEDVESDPG DLVFNILNAP
360 370 380 390 400
THPPGHPGQQ GYVVSTDDPL GLPVSFFTQQ ELRELKIAYQ PPAENSHGER
410 420 430 440 450
LFQLELEVVD GDGAASDPFA FMVTVKSMNT LVPVASHNRG LVLFEGQSRP
460 470 480 490 500
LSSTHSIPIS DKDNLEEVKM AAVRGLRHGQ LVVFGAPAGC KYFTPADLAA
510 520 530 540 550
GRVVYQHDGS NTYSDNIIFR MEDGHHQVDF LFPLTILPVD DEPPMVNTNT
560 570 580 590 600
GLSLTEGQVV QISPFVLSAT DIDSEDSTIH FVLENQPLKG NEEEPQWELA
610 620 630 640 650
PGSSHSGHYL GDLLLQQAEL PLSTEDEDWH YMEKEGLYEK VVTEWLQRDI
660 670 680 690 700
MEGRLFYRHL GPHSPQSVMV QLAFHVQDDH DPPNLSKQHI FTIKVQPVDI
710 720 730 740 750
LSPQLYPGTT LEMTVQEYQL THFQKNFLRY IDQDSDDQNL WYTLLTLPTD
760 770 780 790 800
TDGNHQVRAG EIVLTDSPDT LIMHFTQAQV NQHKVAYQPP QKLGIAPRVV
810 820 830 840 850
QFTYQVEDAA GNSVPGTFTL FLQPVDNQPP EVTNRGFAIL EGGSFNLSSN
860 870 880 890 900
ELHVTDPDTD IDQIVFILVR GPQHGHLQYF KRCMVPGESF MQADVINGSV
910 920 930 940 950
SYQHGRDQTT TSDTFHLEVS DGVHHIPITI PISVHPNVAN RSPRISLRSS
960 970 980 990 1000
SLLDVSIDVL ENKATEITMG VIHGKRKDVG DLMLSFIVKD SPKLGTILVN
1010 1020 1030 1040 1050
GLPTERFTQE DLINGRVAYA HTAGEVGFQK QHDAFSLILS KDSYQWVVGN
1060 1070 1080 1090 1100
SIIEKVQVQV TVLPVDNVGP KVFVGESFIV YEGEKNSLTL QHLHVEDVDT
1110 1120 1130 1140 1150
HQDELLCTVT SQPASGYLEK IASAPGSKMS QSGSPISAFS LRDIQVRHIN
1160 1170 1180 1190 1200
YVQSIHKGVE PQEDQFTFYC SDGINFSPNV FFPIIILPTN DEQPKLFAHE
1210 1220 1230 1240 1250
FKVLEGMSLV IDTQLLNGAD ADLPPNELHF QLTALPRHGR IIQQLATGSQ
1260 1270 1280 1290 1300
PIHSFTLKEI QEASTIVYEH DDSETKEDSF EVWLSDGKHT THRKVPIVVT
1310 1320 1330 1340 1350
LVDDETPHLT VNNGLKVEKG HSEIITNRIL KATDLDSDDK SLSFVLHSGP
1360 1370 1380 1390 1400
QQGLLQRLRK PRGEVRNNLT LGMNFTQDEI NRGLICYIHT GQEGIVDIIK
1410 1420 1430 1440 1450
FDVTDGVNTL TDHYFYVTIG NLDSVFPEVI SKRITLIEGA RVTLTNNLLT
1460 1470 1480 1490 1500
NSDINSSDEH HFSITRAPSL GHLESSDYAG EPIASFTQLQ LASNKISYVH
1510 1520 1530 1540 1550
TSNDEKKMDS FEFQVIGELY PVFRTFRIFI TDVDNKKPIL TIHRLTLQKE
1560 1570 1580 1590 1600
DSQLITLLEL TVEDSDTPDD LILFTITQVP MHGKILYNGS RPVTTFTKQD
1610 1620 1630 1640 1650
LNKNLISYKH DGSETTEDSF SLTVTDGTHT DFYVLPDTAL ATHKPQVMRV
1660 1670 1680 1690 1700
QIRSLDNRLP QITTNRGAPA LKRLHTGHMG FLITSKSLKA EDQDSPHRLL
1710 1720 1730 1740 1750
KYKVTRGPEH GFIIKTGLGN QSTRVFTQAD IDEMKISYVL NEGSNASKDI
1760 1770 1780 1790 1800
FYFSVEDNGG NKLTNQPFHL NWAWICLEKE YYIVDEDSTF LEVTLTRRGY
1810 1820 1830 1840 1850
LGETSFISIG TKDETAKKDK DFKWKTNKQI QFNPGQTTAT WRVRIIPDNE
1860 1870 1880 1890 1900
YETSETFQII LSEPLMAVLE FPEMATVEIV DPGDESTVYI PEAEYKIEED
1910 1920 1930 1940 1950
IGELLIPVRR SGDASQELIV ICSTRQGSAT GTISSTVLFS DYISRPEDHT
1960 1970 1980 1990 2000
SILHFDKNET QKTCQVLIID DSLYEEEESF SVSLRLPVGG QLGARFPTTK
2010 2020 2030 2040 2050
VTILADRYDE PVLHFGDAEY HVNESARYVE VCVWRRGTDL SQPSSIAVRS
2060 2070 2080 2090 2100
RKSEQESAEA GTDYVGISRN LDFAPGVRMQ TFQVTILDDL GQPTLEGPEK
2110 2120 2130
FELLLQMPMG AVLGEPNKTT IFIEDTITDC KQSACSSFD
Length:2,139
Mass (Da):238,179
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F086CB8AFB64E9C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055819412D → N. Corresponds to variant dbSNP:rs4478130Ensembl.1
Natural variantiVAR_059291417D → N. Corresponds to variant dbSNP:rs184496Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC139713 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54808.1

NCBI Reference Sequences

More...
RefSeqi
NP_001161707.1, NM_001168235.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.252714

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329798; ENSP00000332886; ENSG00000183090

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
166752

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:166752

UCSC genome browser

More...
UCSCi
uc021xsj.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139713 Genomic DNA No translation available.
CCDSiCCDS54808.1
RefSeqiNP_001161707.1, NM_001168235.1
UniGeneiHs.252714

3D structure databases

ProteinModelPortaliP0C091
SMRiP0C091
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332886

PTM databases

iPTMnetiP0C091
PhosphoSitePlusiP0C091

Polymorphism and mutation databases

BioMutaiFREM3
DMDMi357528797

Proteomic databases

jPOSTiP0C091
PaxDbiP0C091
PeptideAtlasiP0C091
PRIDEiP0C091
ProteomicsDBi52290

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329798; ENSP00000332886; ENSG00000183090
GeneIDi166752
KEGGihsa:166752
UCSCiuc021xsj.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
166752
DisGeNETi166752
EuPathDBiHostDB:ENSG00000183090.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FREM3
HGNCiHGNC:25172 FREM3
HPAiHPA041641
MIMi608946 gene
neXtProtiNX_P0C091
OpenTargetsiENSG00000183090

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1306 Eukaryota
KOG3597 Eukaryota
ENOG41112TU LUCA
GeneTreeiENSGT00940000162501
HOGENOMiHOG000007464
HOVERGENiHBG081538
InParanoidiP0C091
OMAiWLSDGKH
OrthoDBi13258at2759
PhylomeDBiP0C091
TreeFamiTF316876

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
166752

Protein Ontology

More...
PROi
PR:P0C091

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183090 Expressed in 64 organ(s), highest expression level in dorsolateral prefrontal cortex
GenevisibleiP0C091 HS

Family and domain databases

Gene3Di2.60.40.2030, 3 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR039005 CSPG_rpt
IPR032833 FREM3
PANTHERiPTHR11878:SF31 PTHR11878:SF31, 1 hit
PfamiView protein in Pfam
PF03160 Calx-beta, 3 hits
SMARTiView protein in SMART
SM00237 Calx_beta, 3 hits
SUPFAMiSSF141072 SSF141072, 3 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFREM3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C091
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 16, 2011
Last modified: February 13, 2019
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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