UniProtKB - P0C066 (MLTC_ECOLI)
Protein
Membrane-bound lytic murein transglycosylase C
Gene
mltC
Organism
Escherichia coli (strain K12)
Status
Functioni
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.UniRule annotation
Catalytic activityi
- Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation EC:4.2.2.n1
GO - Molecular functioni
- hydrolase activity, acting on glycosyl bonds Source: InterPro
- lyase activity Source: UniProtKB-KW
- lytic endotransglycosylase activity Source: EcoCyc
- lytic transglycosylase activity Source: EcoCyc
GO - Biological processi
- cellular response to oxidative stress Source: EcoCyc
- cell wall macromolecule catabolic process Source: UniProtKB-UniRule
- cell wall organization Source: UniProtKB-KW
- peptidoglycan catabolic process Source: EcoCyc
Keywordsi
Molecular function | Lyase |
Biological process | Cell wall biogenesis/degradation |
Enzyme and pathway databases
BioCyci | EcoCyc:G7533-MONOMER MetaCyc:G7533-MONOMER |
Protein family/group databases
CAZyi | GH23, Glycoside Hydrolase Family 23 |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane-bound lytic murein transglycosylase CUniRule annotation (EC:4.2.2.n1UniRule annotation)Alternative name(s): Murein lyase CUniRule annotation |
Gene namesi | Name:mltCUniRule annotation Synonyms:yggZ Ordered Locus Names:b2963, JW5481 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
- Cell outer membrane Curated; Lipid-anchor Curated
Other locations
- anchored component of membrane Source: EcoCyc
- cell outer membrane Source: UniProtKB-SubCell
- outer membrane-bounded periplasmic space Source: EcoCyc
Keywords - Cellular componenti
Cell outer membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | UniRule annotationAdd BLAST | 16 | |
ChainiPRO_0000032785 | 17 – 359 | Membrane-bound lytic murein transglycosylase CAdd BLAST | 343 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 17 | N-palmitoyl cysteineUniRule annotation | 1 | |
Lipidationi | 17 | S-diacylglycerol cysteineUniRule annotation | 1 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
jPOSTi | P0C066 |
PaxDbi | P0C066 |
PRIDEi | P0C066 |
Expressioni
Inductioni
By SoxS.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262361, 452 interactors |
STRINGi | 511145.b2963 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0C066 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the transglycosylase Slt family.UniRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG0741, Bacteria |
HOGENOMi | CLU_044583_0_0_6 |
Family and domain databases
HAMAPi | MF_01616, MltC, 1 hit |
InterProi | View protein in InterPro IPR023346, Lysozyme-like_dom_sf IPR023664, Murein_transglycosylaseC IPR024570, Murein_transglycosylaseC_N IPR000189, Transglyc_AS IPR008258, Transglycosylase_SLT_dom_1 |
Pfami | View protein in Pfam PF11873, Mltc_N, 1 hit PF01464, SLT, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS51257, PROKAR_LIPOPROTEIN, 1 hit PS00922, TRANSGLYCOSYLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0C066-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKYLALALI APLLISCSTT KKGDTYNEAW VKDTNGFDIL MGQFAHNIEN
60 70 80 90 100
IWGFKEVVIA GPKDYVKYTD QYQTRSHINF DDGTITIETI AGTEPAAHLR
110 120 130 140 150
RAIIKTLLMG DDPSSVDLYS DVDDITISKE PFLYGQVVDN TGQPIRWEGR
160 170 180 190 200
ASNFADYLLK NRLKSRSNGL RIIYSVTINM VPNHLDKRAH KYLGMVRQAS
210 220 230 240 250
RKYGVDESLI LAIMQTESSF NPYAVSRSDA LGLMQVVQHT AGKDVFRSQG
260 270 280 290 300
KSGTPSRSFL FDPASNIDTG TAYLAMLNNV YLGGIDNPTS RRYAVITAYN
310 320 330 340 350
GGAGSVLRVF SNDKIQAANI INTMTPGDVY QTLTTRHPSA ESRRYLYKVN
TAQKSYRRR
Sequence cautioni
The sequence AAA69130 differs from that shown. Reason: Frameshift.Curated
The sequence AAA69130 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAA69131 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69130.1 Sequence problems. U28377 Genomic DNA Translation: AAA69131.1 Frameshift. U00096 Genomic DNA Translation: AAC76000.2 AP009048 Genomic DNA Translation: BAE77026.1 U59902 Genomic DNA Translation: AAC44296.1 |
PIRi | B65082 |
RefSeqi | NP_417438.2, NC_000913.3 WP_000760323.1, NZ_STEB01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC76000; AAC76000; b2963 BAE77026; BAE77026; BAE77026 |
GeneIDi | 58462896 945428 |
KEGGi | ecj:JW5481 eco:b2963 |
PATRICi | fig|1411691.4.peg.3768 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69130.1 Sequence problems. U28377 Genomic DNA Translation: AAA69131.1 Frameshift. U00096 Genomic DNA Translation: AAC76000.2 AP009048 Genomic DNA Translation: BAE77026.1 U59902 Genomic DNA Translation: AAC44296.1 |
PIRi | B65082 |
RefSeqi | NP_417438.2, NC_000913.3 WP_000760323.1, NZ_STEB01000001.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4C5F | X-ray | 2.34 | A/B | 20-359 | [»] | |
4CFO | X-ray | 2.90 | A/B | 20-359 | [»] | |
4CFP | X-ray | 2.15 | A/B | 20-359 | [»] | |
4CHX | X-ray | 2.45 | A/B | 20-359 | [»] | |
SMRi | P0C066 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262361, 452 interactors |
STRINGi | 511145.b2963 |
Protein family/group databases
CAZyi | GH23, Glycoside Hydrolase Family 23 |
Proteomic databases
jPOSTi | P0C066 |
PaxDbi | P0C066 |
PRIDEi | P0C066 |
Genome annotation databases
EnsemblBacteriai | AAC76000; AAC76000; b2963 BAE77026; BAE77026; BAE77026 |
GeneIDi | 58462896 945428 |
KEGGi | ecj:JW5481 eco:b2963 |
PATRICi | fig|1411691.4.peg.3768 |
Organism-specific databases
EchoBASEi | EB2810 |
Phylogenomic databases
eggNOGi | COG0741, Bacteria |
HOGENOMi | CLU_044583_0_0_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7533-MONOMER MetaCyc:G7533-MONOMER |
Miscellaneous databases
PROi | PR:P0C066 |
Family and domain databases
HAMAPi | MF_01616, MltC, 1 hit |
InterProi | View protein in InterPro IPR023346, Lysozyme-like_dom_sf IPR023664, Murein_transglycosylaseC IPR024570, Murein_transglycosylaseC_N IPR000189, Transglyc_AS IPR008258, Transglycosylase_SLT_dom_1 |
Pfami | View protein in Pfam PF11873, Mltc_N, 1 hit PF01464, SLT, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS51257, PROKAR_LIPOPROTEIN, 1 hit PS00922, TRANSGLYCOSYLASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MLTC_ECOLI | |
Accessioni | P0C066Primary (citable) accession number: P0C066 Secondary accession number(s): P52066 Q2M9N0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | April 7, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families