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Entry version 69 (23 Feb 2022)
Sequence version 2 (23 Jan 2007)
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Protein

Gramicidin S synthase 2

Gene

grsB

Organism
Aneurinibacillus migulanus (Bacillus migulanus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a multifunctional enzyme, able to activate and polymerize the amino acids Pro, Val, Orn and Leu. Activation sites for these AA consist of individual domains.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateNote: Binds 4 phosphopantetheines covalently.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gramicidin S biosynthesis

This protein is involved in the pathway gramicidin S biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gramicidin S biosynthesis and in Antibiotic biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Ligase, Multifunctional enzyme
Biological processAntibiotic biosynthesis

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00102

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gramicidin S synthase 2
Alternative name(s):
Gramicidin S synthase II
Including the following 4 domains:
ATP-dependent proline adenylase
Short name:
ProA
Alternative name(s):
Proline activase
ATP-dependent valine adenylase
Short name:
ValA
Alternative name(s):
Valine activase
ATP-dependent ornithine adenylase
Short name:
OrnA
Alternative name(s):
Ornithine activase
ATP-dependent leucine adenylase
Short name:
LeuA
Alternative name(s):
Leucine activase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:grsB
Synonyms:grs2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAneurinibacillus migulanus (Bacillus migulanus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri47500 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeAneurinibacillus groupAneurinibacillus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930872 – 4451Gramicidin S synthase 2Add BLAST4450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1006O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2041O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3087O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4125O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P0C063

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Large multienzyme complex of GrsA and GrsB.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
47500.AF333_17645

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C063

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini971 – 1046Carrier 1PROSITE-ProRule annotationAdd BLAST76
Domaini2006 – 2081Carrier 2PROSITE-ProRule annotationAdd BLAST76
Domaini3052 – 3127Carrier 3PROSITE-ProRule annotationAdd BLAST76
Domaini4090 – 4165Carrier 4PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni467 – 1044Domain 1 (proline-activating)By similarityAdd BLAST578
Regioni1521 – 2080Domain 2 (valine-activating)By similarityAdd BLAST560
Regioni2538 – 3135Domain 3 (ornithine-activating)By similarityAdd BLAST598
Regioni3591 – 4173Domain 4 (leucine-activating)Add BLAST583

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of four modules, and harbors a putative thioesterase domain at its C-terminal end. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional), and N methylation (optional).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.300.30, 4 hits
3.30.559.10, 4 hits
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR001031, Thioesterase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 4 hits
PF13193, AMP-binding_C, 4 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 4 hits
PF00975, Thioesterase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 4 hits
SSF53474, SSF53474, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 4 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0C063-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTFKKEHVQ DMYRLSPMQE GMLFHALLDK DKNAHLVQMS IAIEGIVDVE
60 70 80 90 100
LLSESLNILI DRYDVFRTTF LHEKIKQPLQ VVLKERPVQL QFKDISSLDE
110 120 130 140 150
EKREQAIEQY KYQDGETVFD LTRDPLMRVA IFQTGKVNYQ MIWSFHHILM
160 170 180 190 200
DGWCFNIIFN DLFNIYLSLK EKKPLQLEAV QPYKQFIKWL EKQDKQEALR
210 220 230 240 250
YWKEHLMNYD QSVTLPKKKA AINNTTYEPA QFRFAFDKVL TQQLLRIANQ
260 270 280 290 300
SQVTLNIVFQ TIWGIVLQKY NSTNHVVYGS VVSGRPSEIS GIEKMVGLFI
310 320 330 340 350
NTLPLRIQTQ KDQSFIELVK TVHQNVLFSQ QHEYFPLYEI QNHTELKQNL
360 370 380 390 400
IDHIMVIENY PLVEELQKNS IMQKVGFTVR DVKMFEPTNY DMTVMVLPRD
410 420 430 440 450
EISVRLDYNA AVYDIDFIKK IEGHMKEVAL CVANNPHVLV QDVPLLTKQE
460 470 480 490 500
KQHLLVELHD SITEYPDKTI HQLFTEQVEK TPEHVAVVFE DEKVTYRELH
510 520 530 540 550
ERSNQLARFL REKGVKKESI IGIMMERSVE MIVGILGILK AGGAFVPIDP
560 570 580 590 600
EYPKERIGYM LDSVRLVLTQ RHLKDKFAFT KETIVIEDPS ISHELTEEID
610 620 630 640 650
YINESEDLFY IIYTSGTTGK PKGVMLEHKN IVNLLHFTFE KTNINFSDKV
660 670 680 690 700
LQYTTCSFDV CYQEIFSTLL SGGQLYLIRK ETQRDVEQLF DLVKRENIEV
710 720 730 740 750
LSFPVAFLKF IFNEREFINR FPTCVKHIIT AGEQLVVNNE FKRYLHEHNV
760 770 780 790 800
HLHNHYGPSE THVVTTYTIN PEAEIPELPP IGKPISNTWI YILDQEQQLQ
810 820 830 840 850
PQGIVGELYI SGANVGRGYL NNQELTAEKF FADPFRPNER MYRTGDLARW
860 870 880 890 900
LPDGNIEFLG RADHQVKIRG HRIELGEIEA QLLNCKGVKE AVVIDKADDK
910 920 930 940 950
GGKYLCAYVV MEVEVNDSEL REYLGKALPD YMIPSFFVPL DQLPLTPNGK
960 970 980 990 1000
IDRKSLPNLE GIVNTNAKYV VPTNELEEKL AKIWEEVLGI SQIGIQDNFF
1010 1020 1030 1040 1050
SLGGHSLKAI TLISRMNKEC NVDIPLRLLF EAPTIQEISN YINGAKKESY
1060 1070 1080 1090 1100
VAIQPVPEQE YYPVSSVQKR MFILNEFDRS GTAYNLPGVM FLDGKLNYRQ
1110 1120 1130 1140 1150
LEAAVKKLVE RHEALRTSFH SINGEPVQRV HQNVELQIAY SESTEDQVER
1160 1170 1180 1190 1200
IIAEFMQPFA LEVRPLLRVG LVKLEAERHL FIMDMHHIIS DGVSMQIMIQ
1210 1220 1230 1240 1250
EIADLYKEKE LPTLGIQYKD FTVWHNRLLQ SDVIEKQEAY WLNVFTEEIP
1260 1270 1280 1290 1300
VLNLPTDYPR PTIQSFDGKR FTFSTGKQLM DDLYKVATET GTTLYMVLLA
1310 1320 1330 1340 1350
AYNVFLSKYS GQDDIVVGTP IAGRSHADVE NMLGMFVNTL AIRSRLNNED
1360 1370 1380 1390 1400
TFKDFLANVK QTALHAYENP DYPFDTLVEK LGIQRDLSRN PLFDTMFVLQ
1410 1420 1430 1440 1450
NTDRKSFEVE QITITPYVPN SRHSKFDLTL EVSEEQNEIL LCLEYCTKLF
1460 1470 1480 1490 1500
TDKTVERMAG HFLQILHAIV GNPTIIISEI EILSEEEKQH ILFEFNDTKT
1510 1520 1530 1540 1550
TYPHMQTIQG LFEEQVEKTP DHVAVGWKDQ TLTYRELNER ANQVARVLRQ
1560 1570 1580 1590 1600
KGVQPDNIVG LLVERSPEML VGIMGILKAG GAYLPLDPEY PADRISYMIQ
1610 1620 1630 1640 1650
DCGVRIMLTQ QHLLSLVHDE FDCVILDEDS LYKGDSSNLA PVNQAGDLAY
1660 1670 1680 1690 1700
IMYTSGSTGK PKGVMVEHRN VIRLVKNTNY VQVREDDRII QTGAIGFDAL
1710 1720 1730 1740 1750
TFEVFGSLLH GAELYPVTKD VLLDAEKLHK FLQANQITIM WLTSPLFNQL
1760 1770 1780 1790 1800
SQGTEEMFAG LRSLIVGGDA LSPKHINNVK RKCPNLTMWN GYGPTENTTF
1810 1820 1830 1840 1850
STCFLIDKEY DDNIPIGKAI SNSTVYIMDR YGQLQPVGVP GELCVGGDGV
1860 1870 1880 1890 1900
ARGYMNQPAL TEEKFVPNPF APGERMYRTG DLARWLPDGT IEYLGRIDQQ
1910 1920 1930 1940 1950
VKIRGYRIEP GEIETLLVKH KKVKESVIMV VEDNNGQKAL CAYYVPEEEV
1960 1970 1980 1990 2000
TVSELREYIA KELPVYMVPA YFVQIEQMPL TQNGKVNRSA LPKPDGEFGT
2010 2020 2030 2040 2050
ATEYVAPSSD IEMKLAEIWH NVLGVNKIGV LDNFFELGGH SLRAMTMISQ
2060 2070 2080 2090 2100
VHKEFDVELP LKVLFETPTI SALAQYIADG QKGMYLAIQP VTPTDYYPVS
2110 2120 2130 2140 2150
SAQKRMYILY EFEGAGITYN VPNVMFIEGK LDYQRFEYAI KSLVNRHEAL
2160 2170 2180 2190 2200
RTSFYSLNGE PVQRVHQNVE LQIAYSEAKE DEIEQIVESF VQPFDLEIAP
2210 2220 2230 2240 2250
LLRVGLVKLA SDRYLFLMDM HHIISDGVSM QIITKEIADL YKGKELAELH
2260 2270 2280 2290 2300
IQYKDFAVWQ NEWFQSDALE KQKTYWLNTF AEDIPVLNLS TDYPRPTIQS
2310 2320 2330 2340 2350
FEGDIVTFSA GKQLAEELKR LAAETGTTLY MLLLAAYNVL LHKYSGQEEI
2360 2370 2380 2390 2400
VVGTPIAGRS HADVENIVGM FVNTLALKNT PIAVRTFHEF LLEVKQNALE
2410 2420 2430 2440 2450
AFENQDYPFE NLIEKLQVRR DLSRNPLFDT MFSLSNIDEQ VEIGIEGLNF
2460 2470 2480 2490 2500
SPYEMQYWIA KFDISFDILE KQDDIQFYFN YCTNLFKKET IERLATHFMH
2510 2520 2530 2540 2550
ILQEIVINPE IKLCEINMLS EEEQQRVLYD FNGTDATYAT NKIFHELFEE
2560 2570 2580 2590 2600
QVEKTPDHIA VIDEREKLSY QELNAKANQL ARVLRQKGVQ PNSMVGIMVD
2610 2620 2630 2640 2650
RSLDMIVGML GVLKAGGAYV PIDIDYPQER ISYMMEDSGA ALLLTQQKLT
2660 2670 2680 2690 2700
QQIAFSGDIL YLDQEEWLHE EASNLEPIAR PHYIAYIIYT SGTTGKPKGV
2710 2720 2730 2740 2750
MIEHQSYVNV AMAWKDAYRL DTFPVRLLQM ASFAFAFDVS AGDFARALLT
2760 2770 2780 2790 2800
GGQLIVCPNE VKMDPASLYA IIKKYDITIF EATPALVIPL MEYIYEQKLD
2810 2820 2830 2840 2850
ISQLQILIVG SDSCSMEDFK TLVSRFGSTI RIVNSYGVTE ACIDSSYYEQ
2860 2870 2880 2890 2900
PLSSLHVTGT VPIGKPYANM KMYIMNQYLQ IQPVGVIGEL CIGGAGVARG
2910 2920 2930 2940 2950
YLNRPDLTAE KFVPNPFVPG EKLYRTGDLA RWMPDGNVEF LGRNDHQVKI
2960 2970 2980 2990 3000
RGIRIELGEI EAQLRKHDSI KEATVIARED HMKEKYLCAY MVTEGEVNVA
3010 3020 3030 3040 3050
ELRAYLANDR AAMIPSYFVS LEAMPLTANG KIDKRSLPEP DGSISIGTEY
3060 3070 3080 3090 3100
DRPRTMLEGK LEEIWKDVLG LQRVGIHDDF FTIGGHSLKA MAVISQVHKE
3110 3120 3130 3140 3150
CQTEVPLRVL FETPTIQGLA KYIEETDTEQ YMAIQPVSGQ DYYPVSSAQK
3160 3170 3180 3190 3200
RMFIVNQFVG VGISYNMPSI MLIEGKLERT RLESAFKRLI ERHESLRTSF
3210 3220 3230 3240 3250
EIINGKPVQK IHEEVDFNMS YQVASNEQVE KMIDEFIQPF DLSVAPLLRV
3260 3270 3280 3290 3300
ELLKLEEDRH VLIFDMHHII SDGISSNILM KELGELYQGN ALPELRIQYK
3310 3320 3330 3340 3350
DFAVWQNEWF QSEAFKKQEE YWVNVFADER PILDIPTDYP RPMQQSFDGA
3360 3370 3380 3390 3400
QLTFGTGKQL MDGLYRVATE TGTTLYMVLL AAYNVLLSKY SGQEDIIVGT
3410 3420 3430 3440 3450
PIVGRSHTDL ENIVGMFVNT LAMRNKPEGE KTFKAFVSEI KQNALAAFEN
3460 3470 3480 3490 3500
QDYPFEELIE KLEIQRDLSR NPLFDTLFSL QNIGEESFEL AELTCKPFDL
3510 3520 3530 3540 3550
VSKLEHAKFD LSLVAVVFEE EIAFGLQYCT KLYKEKTVEQ LAQHFIQIVK
3560 3570 3580 3590 3600
AIVENPDVKL SDIDMLSEEE KKQIMLEFND TKIQYTQNQT IQELFEEQVK
3610 3620 3630 3640 3650
KTPEHIAIVW EGQALIYHEL NIKANQLARV LREKGVTPNH PVAIMTERSL
3660 3670 3680 3690 3700
EMIVGIFSIL KAGGAYVPID PAYPQERIQY LLEDSGAALL LTQSHVLNKL
3710 3720 3730 3740 3750
PVDIEWLDLT DEQNYVEDGT NLPFMNQSTD LAYIIYTSGT TGKPKGVMIE
3760 3770 3780 3790 3800
HQSIINCLQW RKEEYEFGPG DTALQVFSFA FDGFVASLFA PILAGATSVL
3810 3820 3830 3840 3850
PKEEEAKDPV ALKKLIASEE ITHYYGVPSL FSAILDVSSS KDLQNLRCVT
3860 3870 3880 3890 3900
LGGEKLPAQI VKKIKEKNKE IEVNNEYGPT ENSVVTTIMR DIQVEQEITI
3910 3920 3930 3940 3950
GRPLSNVDVY IVNCNHQLQP VGVVGELCIG GQGLARGYLN KPELTADKFV
3960 3970 3980 3990 4000
VNPFVPGERM YKTGDLAKWR SDGMIEYVGR VDEQVKVRGY RIELGEIESA
4010 4020 4030 4040 4050
ILEYEKIKEA VVMVSEHTAS EQMLCAYIVG EEDVLTLDLR SYLAKLLPSY
4060 4070 4080 4090 4100
MIPNYFIQLD SIPLTPNGKV DRKALPEPQT IGLMAREYVA PRNEIEAQLV
4110 4120 4130 4140 4150
LIWQEVLGIE LIGITDNFFE LGGHSLKATL LVAKIYEYMQ IEMPLNVVFK
4160 4170 4180 4190 4200
HSTIMKIAEY ITHQESENNV HQPILVNVEA DREALSLNGE KQRKNIELPI
4210 4220 4230 4240 4250
LLNEETDRNV FLFAPIGAQG VFYKKLAEQI PTASLYGFDF IEDDDRIQQY
4260 4270 4280 4290 4300
IESMIQTQSD GQYVLIGYSS GGNLAFEVAK EMERQGYSVS DLVLFDVYWK
4310 4320 4330 4340 4350
GKVFEQTKEE EEENIKIIME ELRENPGMFN MTREDFELYF ANEFVKQSFT
4360 4370 4380 4390 4400
RKMRKYMSFY TQLVNYGEVE ATIHLIQAEF EEEKIDENEK ADEEEKTYLE
4410 4420 4430 4440 4450
EKWNEKAWNK AAKRFVKYNG YGAHSNMLGG DGLERNSSIL KQILQGTFVV

K
Length:4,451
Mass (Da):509,254
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C6DBA8B27636121
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti655 – 665TCSFDVCYQEI → NAVLTCVTKKF in CAA43838 (PubMed:1560782).CuratedAdd BLAST11
Sequence conflicti942 – 947QLPLTP → HVRLHL in CAA43838 (PubMed:1560782).Curated6
Sequence conflicti1240 – 1304YWLNV…AAYNV → SLAERICRRDSSIESTDRLP KYQPFKALMVKDLHSVQESS LWMIYTRWQQKQEQHYIWFY LLRIMF in CAA43838 (PubMed:1560782).CuratedAdd BLAST65
Sequence conflicti1504 – 1520HMQTI…VEKTP → LCKQFKDYLRNRWRRRA in CAA43838 (PubMed:1560782).CuratedAdd BLAST17
Sequence conflicti2842 – 2849CIDSSYYE → ALILAIMN in CAA43838 (PubMed:1560782).Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X61658 Genomic DNA Translation: CAA43838.1
M29703 Genomic DNA Translation: AAA58719.1
X15577 Genomic DNA Translation: CAA33604.1

Protein sequence database of the Protein Information Resource

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PIRi
S20542, YGBSG2

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ag:CAA43838

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61658 Genomic DNA Translation: CAA43838.1
M29703 Genomic DNA Translation: AAA58719.1
X15577 Genomic DNA Translation: CAA33604.1
PIRiS20542, YGBSG2

3D structure databases

SMRiP0C063
ModBaseiSearch...

Protein-protein interaction databases

STRINGi47500.AF333_17645

Proteomic databases

PRIDEiP0C063

Genome annotation databases

KEGGiag:CAA43838

Enzyme and pathway databases

UniPathwayiUPA00102

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.300.30, 4 hits
3.30.559.10, 4 hits
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR001031, Thioesterase
PfamiView protein in Pfam
PF00501, AMP-binding, 4 hits
PF13193, AMP-binding_C, 4 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 4 hits
PF00975, Thioesterase, 1 hit
SMARTiView protein in SMART
SM00823, PKS_PP, 4 hits
SUPFAMiSSF47336, SSF47336, 4 hits
SSF53474, SSF53474, 1 hit
TIGRFAMsiTIGR01733, AA-adenyl-dom, 4 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 4 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 4 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRSB_ANEMI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C063
Secondary accession number(s): P14688, Q44928
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: January 23, 2007
Last modified: February 23, 2022
This is version 69 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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