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Protein

Small heat shock protein IbpB

Gene

ibpB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.3 Publications

Temperature dependencei

Thermostable up to 50 degrees Celsius.

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

GO - Biological processi

  • protein stabilization Source: UniProtKB-UniRule
  • response to heat Source: EcoCyc
  • stress response to copper ion Source: EcoCyc

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

BioCyciEcoCyc:EG11535-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Small heat shock protein IbpB
Alternative name(s):
16 kDa heat shock protein B
Gene namesi
Name:ibpB
Synonyms:hslS, htpE
Ordered Locus Names:b3686, JW3663
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11535 ibpB

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260281 – 142Small heat shock protein IbpBAdd BLAST142

Proteomic databases

PaxDbiP0C058
PRIDEiP0C058

Expressioni

Inductioni

By heat shock.1 Publication

Interactioni

Subunit structurei

Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4260809, 224 interactors
DIPiDIP-48244N
IntActiP0C058, 11 interactors
MINTiP0C058
STRINGi316385.ECDH10B_3872

Structurei

3D structure databases

ProteinModelPortaliP0C058
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 137sHSPPROSITE-ProRule annotationAdd BLAST112

Domaini

The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.1 Publication

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiENOG4108SHS Bacteria
COG0071 LUCA
HOGENOMiHOG000251750
InParanoidiP0C058
KOiK04081
OMAiKASDGYP
PhylomeDBiP0C058

Family and domain databases

CDDicd06470 ACD_IbpA-B_like, 1 hit
Gene3Di2.60.40.790, 1 hit
HAMAPiMF_02001 HSP20_IbpB, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037913 ACD_IbpA/B
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR022848 HSP20_IbpB
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

P0C058-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNFDLSPLM RQWIGFDKLA NALQNAGESQ SFPPYNIEKS DDNHYRITLA
60 70 80 90 100
LAGFRQEDLE IQLEGTRLSV KGTPEQPKEE KKWLHQGLMN QPFSLSFTLA
110 120 130 140
ENMEVSGATF VNGLLHIDLI RNEPEPIAAQ RIAISERPAL NS
Length:142
Mass (Da):16,093
Last modified:July 5, 2005 - v1
Checksum:i7666BB1BDB8A673A
GO

Sequence cautioni

The sequence AAA62038 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94104 Genomic DNA Translation: AAA24425.1
L10328 Genomic DNA Translation: AAA62038.1 Different initiation.
U00096 Genomic DNA Translation: AAC76709.2
AP009048 Genomic DNA Translation: BAE77608.1
RefSeqiNP_418141.2, NC_000913.3
WP_001243431.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76709; AAC76709; b3686
BAE77608; BAE77608; BAE77608
GeneIDi948192
KEGGiecj:JW3663
eco:b3686
PATRICifig|511145.12.peg.3808

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94104 Genomic DNA Translation: AAA24425.1
L10328 Genomic DNA Translation: AAA62038.1 Different initiation.
U00096 Genomic DNA Translation: AAC76709.2
AP009048 Genomic DNA Translation: BAE77608.1
RefSeqiNP_418141.2, NC_000913.3
WP_001243431.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0C058
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260809, 224 interactors
DIPiDIP-48244N
IntActiP0C058, 11 interactors
MINTiP0C058
STRINGi316385.ECDH10B_3872

Proteomic databases

PaxDbiP0C058
PRIDEiP0C058

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76709; AAC76709; b3686
BAE77608; BAE77608; BAE77608
GeneIDi948192
KEGGiecj:JW3663
eco:b3686
PATRICifig|511145.12.peg.3808

Organism-specific databases

EchoBASEiEB1497
EcoGeneiEG11535 ibpB

Phylogenomic databases

eggNOGiENOG4108SHS Bacteria
COG0071 LUCA
HOGENOMiHOG000251750
InParanoidiP0C058
KOiK04081
OMAiKASDGYP
PhylomeDBiP0C058

Enzyme and pathway databases

BioCyciEcoCyc:EG11535-MONOMER

Miscellaneous databases

PROiPR:P0C058

Family and domain databases

CDDicd06470 ACD_IbpA-B_like, 1 hit
Gene3Di2.60.40.790, 1 hit
HAMAPiMF_02001 HSP20_IbpB, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037913 ACD_IbpA/B
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR022848 HSP20_IbpB
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBPB_ECOLI
AccessioniPrimary (citable) accession number: P0C058
Secondary accession number(s): P29210, P76733, Q2M7Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: October 10, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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