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Protein

Small heat shock protein IbpA

Gene

ibpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.2 Publications

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

GO - Biological processi

  • protein stabilization Source: UniProtKB-UniRule
  • response to heat Source: EcoCyc

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

BioCyciEcoCyc:EG11534-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Small heat shock protein IbpA
Alternative name(s):
16 kDa heat shock protein A
Gene namesi
Name:ibpA
Synonyms:hslT, htpN
Ordered Locus Names:b3687, JW3664
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11534 ibpA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260171 – 137Small heat shock protein IbpAAdd BLAST137

Proteomic databases

PaxDbiP0C054
PRIDEiP0C054

2D gel databases

SWISS-2DPAGEiP0C054

Expressioni

Inductioni

By heat shock.

Interactioni

Subunit structurei

Monomer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to monomers at high temperatures or high ionic concentrations.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4262590, 160 interactors
DIPiDIP-47849N
IntActiP0C054, 50 interactors
MINTiP0C054
STRINGi316385.ECDH10B_3873

Structurei

3D structure databases

ProteinModelPortaliP0C054
SMRiP0C054
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 137sHSPPROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiENOG4108ZNX Bacteria
COG0071 LUCA
HOGENOMiHOG000251750
InParanoidiP0C054
KOiK04080
OMAiTAHDNML
PhylomeDBiP0C054

Family and domain databases

CDDicd06470 ACD_IbpA-B_like, 1 hit
Gene3Di2.60.40.790, 1 hit
HAMAPiMF_02000 HSP20_IbpA, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037913 ACD_IbpA/B
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR023728 HSP20_IbpA
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

P0C054-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNFDLSPLY RSAIGFDRLF NHLENNQSQS NGGYPPYNVE LVDENHYRIA
60 70 80 90 100
IAVAGFAESE LEITAQDNLL VVKGAHADEQ KERTYLYQGI AERNFERKFQ
110 120 130
LAENIHVRGA NLVNGLLYID LERVIPEAKK PRRIEIN
Length:137
Mass (Da):15,774
Last modified:July 5, 2005 - v1
Checksum:iE7BB51421F5CEF3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94104 Genomic DNA Translation: AAA24424.1
L10328 Genomic DNA Translation: AAA62039.1
U00096 Genomic DNA Translation: AAC76710.1
AP009048 Genomic DNA Translation: BAE77607.1
PIRiA45245
RefSeqiNP_418142.1, NC_000913.3
WP_001243437.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76710; AAC76710; b3687
BAE77607; BAE77607; BAE77607
GeneIDi948200
KEGGiecj:JW3664
eco:b3687
PATRICifig|511145.12.peg.3809

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94104 Genomic DNA Translation: AAA24424.1
L10328 Genomic DNA Translation: AAA62039.1
U00096 Genomic DNA Translation: AAC76710.1
AP009048 Genomic DNA Translation: BAE77607.1
PIRiA45245
RefSeqiNP_418142.1, NC_000913.3
WP_001243437.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0C054
SMRiP0C054
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262590, 160 interactors
DIPiDIP-47849N
IntActiP0C054, 50 interactors
MINTiP0C054
STRINGi316385.ECDH10B_3873

2D gel databases

SWISS-2DPAGEiP0C054

Proteomic databases

PaxDbiP0C054
PRIDEiP0C054

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76710; AAC76710; b3687
BAE77607; BAE77607; BAE77607
GeneIDi948200
KEGGiecj:JW3664
eco:b3687
PATRICifig|511145.12.peg.3809

Organism-specific databases

EchoBASEiEB1496
EcoGeneiEG11534 ibpA

Phylogenomic databases

eggNOGiENOG4108ZNX Bacteria
COG0071 LUCA
HOGENOMiHOG000251750
InParanoidiP0C054
KOiK04080
OMAiTAHDNML
PhylomeDBiP0C054

Enzyme and pathway databases

BioCyciEcoCyc:EG11534-MONOMER

Miscellaneous databases

PROiPR:P0C054

Family and domain databases

CDDicd06470 ACD_IbpA-B_like, 1 hit
Gene3Di2.60.40.790, 1 hit
HAMAPiMF_02000 HSP20_IbpA, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037913 ACD_IbpA/B
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR023728 HSP20_IbpA
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBPA_ECOLI
AccessioniPrimary (citable) accession number: P0C054
Secondary accession number(s): P29209, Q2M7Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: October 10, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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