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Protein

Nucleoside diphosphate-linked moiety X motif 17

Gene

NUDT17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi142Magnesium or manganeseBy similarity1
Metal bindingi146Magnesium or manganeseBy similarity1

GO - Molecular functioni

  • hydrolase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • NADH pyrophosphatase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 17 (EC:3.6.1.-)
Short name:
Nudix motif 17
Gene namesi
Name:NUDT17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000186364.11
HGNCiHGNC:26618 NUDT17
neXtProtiNX_P0C025

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186364
PharmGKBiPA134890899

Polymorphism and mutation databases

BioMutaiNUDT17
DMDMi254763318

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000199531 – 328Nucleoside diphosphate-linked moiety X motif 17Add BLAST328

Proteomic databases

PaxDbiP0C025
PRIDEiP0C025
ProteomicsDBi52289

PTM databases

iPTMnetiP0C025
PhosphoSitePlusiP0C025

Expressioni

Gene expression databases

BgeeiENSG00000186364 Expressed in 139 organ(s), highest expression level in oviduct epithelium
CleanExiHS_NUDT17
GenevisibleiP0C025 HS

Organism-specific databases

HPAiHPA030145

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334437

Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0C025
SMRiP0C025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 236Nudix hydrolasePROSITE-ProRule annotationAdd BLAST147

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 148Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiENOG410IVB3 Eukaryota
ENOG4111BBY LUCA
GeneTreeiENSGT00390000013847
HOGENOMiHOG000253927
HOVERGENiHBG056751
InParanoidiP0C025
OMAiLPKYHHI
OrthoDBiEOG091G0G7N
PhylomeDBiP0C025
TreeFamiTF313611

Family and domain databases

CDDicd04694 Nudix_Hydrolase_35, 1 hit
InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR033716 Nudt17_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequencei

Sequence statusi: Complete.

P0C025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVRVQLLL SRRPESVSFA RSVCGLLGAG PGLGTWPIHC SLKRGRLVLS
60 70 80 90 100
SRPFPGASAR LPLQRPPFCP FAALEERPRV PGAELPTDRG VDLGVAVILQ
110 120 130 140 150
SSDKTVLLTR RARTLSVSPN LWVPPGGHVE LEEELLDGGL RELWEESGLH
160 170 180 190 200
LPQGQFSWVP LGLWESAYPP RLSWGLPKYH HIVLYLLVIS QESQQQLQAR
210 220 230 240 250
IQPNPNEVSA LMWLTPDVAA AVAAAEDGTE TPGLLPQDLP PSVLAVELEE
260 270 280 290 300
DGRARPLVLH MSTLLRMIPT MAEDKERVST GTKFALKLWL QHLGRTPPPC
310 320
KSAAYLDPGP AKEEWNMDPL PPNQGSGK
Length:328
Mass (Da):35,923
Last modified:July 28, 2009 - v2
Checksum:iFD6FEF1EFB6E842D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160282 Genomic DNA No translation available.
CCDSiCCDS72865.1
RefSeqiNP_001012776.1, NM_001012758.2
UniGeneiHs.585066

Genome annotation databases

EnsembliENST00000334513; ENSP00000334437; ENSG00000186364
GeneIDi200035
KEGGihsa:200035
UCSCiuc001eoe.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160282 Genomic DNA No translation available.
CCDSiCCDS72865.1
RefSeqiNP_001012776.1, NM_001012758.2
UniGeneiHs.585066

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LF8X-ray2.56A1-328[»]
ProteinModelPortaliP0C025
SMRiP0C025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334437

PTM databases

iPTMnetiP0C025
PhosphoSitePlusiP0C025

Polymorphism and mutation databases

BioMutaiNUDT17
DMDMi254763318

Proteomic databases

PaxDbiP0C025
PRIDEiP0C025
ProteomicsDBi52289

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334513; ENSP00000334437; ENSG00000186364
GeneIDi200035
KEGGihsa:200035
UCSCiuc001eoe.4 human

Organism-specific databases

CTDi200035
EuPathDBiHostDB:ENSG00000186364.11
GeneCardsiNUDT17
HGNCiHGNC:26618 NUDT17
HPAiHPA030145
neXtProtiNX_P0C025
OpenTargetsiENSG00000186364
PharmGKBiPA134890899
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB3 Eukaryota
ENOG4111BBY LUCA
GeneTreeiENSGT00390000013847
HOGENOMiHOG000253927
HOVERGENiHBG056751
InParanoidiP0C025
OMAiLPKYHHI
OrthoDBiEOG091G0G7N
PhylomeDBiP0C025
TreeFamiTF313611

Miscellaneous databases

GenomeRNAii200035
PROiPR:P0C025

Gene expression databases

BgeeiENSG00000186364 Expressed in 139 organ(s), highest expression level in oviduct epithelium
CleanExiHS_NUDT17
GenevisibleiP0C025 HS

Family and domain databases

CDDicd04694 Nudix_Hydrolase_35, 1 hit
InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR033716 Nudt17_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUD17_HUMAN
AccessioniPrimary (citable) accession number: P0C025
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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