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Protein

Xanthine permease XanP

Gene

xanP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specific, proton motive force-dependent high-affinity transporter for xanthine.1 Publication

Enzyme regulationi

Inhibited by CCCP and N-ethylmaleimide.1 Publication

Kineticsi

  1. KM=2.9 µM for xanthine1 Publication
  1. Vmax=0.59 nmol/min/mg enzyme1 Publication

GO - Molecular functioni

  • xanthine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • xanthine transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YICE-MONOMER
MetaCyc:YICE-MONOMER

Protein family/group databases

TCDBi2.A.40.4.2 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine permease XanP
Gene namesi
Name:xanP
Synonyms:yicE
Ordered Locus Names:b3654, JW3629
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11194 xanP

Subcellular locationi

  • Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659691 – 463Xanthine permease XanPAdd BLAST463

Proteomic databases

PaxDbiP0AGM9
PRIDEiP0AGM9

Interactioni

Protein-protein interaction databases

BioGridi4262570, 8 interactors
STRINGi316385.ECDH10B_3836

Structurei

3D structure databases

ProteinModelPortaliP0AGM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C2W Bacteria
COG2233 LUCA
HOGENOMiHOG000038198
InParanoidiP0AGM9
KOiK16345
OMAiFAYIGAC
PhylomeDBiP0AGM9

Family and domain databases

InterProiView protein in InterPro
IPR006042 Xan_ur_permease
IPR006043 Xant/urac/vitC
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit
TIGRFAMsiTIGR00801 ncs2, 1 hit
PROSITEiView protein in PROSITE
PS01116 XANTH_URACIL_PERMASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0AGM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSTLESEN AQPVAQTQNS ELIYRLEDRP PLPQTLFAAC QHLLAMFVAV
60 70 80 90 100
ITPALLICQA LGLPAQDTQH IISMSLFASG VASIIQIKAW GPVGSGLLSI
110 120 130 140 150
QGTSFNFVAP LIMGGTALKT GGADVPTMMA ALFGTLMLAS CTEMVISRVL
160 170 180 190 200
HLARRIITPL VSGVVVMIIG LSLIQVGLTS IGGGYAAMSD NTFGAPKNLL
210 220 230 240 250
LAGVVLALII LLNRQRNPYL RVASLVIAMA AGYALAWFMG MLPESNEPMT
260 270 280 290 300
QELIMVPTPL YYGLGIEWSL LLPLMLVFMI TSLETIGDIT ATSDVSEQPV
310 320 330 340 350
SGPLYMKRLK GGVLANGLNS FVSAVFNTFP NSCFGQNNGV IQLTGVASRY
360 370 380 390 400
VGFVVALMLI VLGLFPAVSG FVQHIPEPVL GGATLVMFGT IAASGVRIVS
410 420 430 440 450
REPLNRRAIL IIALSLAVGL GVSQQPLILQ FAPEWLKNLL SSGIAAGGIT
460
AIVLNLIFPP EKQ
Length:463
Mass (Da):48,868
Last modified:December 20, 2005 - v1
Checksum:i868718559103456E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62007.1
U00096 Genomic DNA Translation: AAC76678.1
AP009048 Genomic DNA Translation: BAE77639.1
X17499 Genomic DNA No translation available.
PIRiH65166
RefSeqiNP_418111.1, NC_000913.3
WP_001295238.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76678; AAC76678; b3654
BAE77639; BAE77639; BAE77639
GeneIDi948172
KEGGiecj:JW3629
eco:b3654
PATRICifig|511145.12.peg.3774

Similar proteinsi

Entry informationi

Entry nameiXANP_ECOLI
AccessioniPrimary (citable) accession number: P0AGM9
Secondary accession number(s): P27432, Q2M7W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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