UniProtKB - P0AGM9 (XANP_ECOLI)
Protein
Xanthine permease XanP
Gene
xanP
Organism
Escherichia coli (strain K12)
Status
Functioni
Specific, proton motive force-dependent high-affinity transporter for xanthine.1 Publication
Activity regulationi
Inhibited by CCCP and N-ethylmaleimide.1 Publication
Kineticsi
- KM=2.9 µM for xanthine1 Publication
- Vmax=0.59 nmol/min/mg enzyme1 Publication
GO - Molecular functioni
- xanthine transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- xanthine transport Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YICE-MONOMER MetaCyc:YICE-MONOMER |
Protein family/group databases
TCDBi | 2.A.40.4.2, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family |
Names & Taxonomyi
Protein namesi | Recommended name: Xanthine permease XanP |
Gene namesi | Name:xanP Synonyms:yicE Ordered Locus Names:b3654, JW3629 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 71 – 91 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 156 – 176 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 222 – 242 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 260 – 280 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 352 – 372 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 379 – 399 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 409 – 429 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 439 – 459 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000165969 | 1 – 463 | Xanthine permease XanPAdd BLAST | 463 |
Proteomic databases
PaxDbi | P0AGM9 |
PRIDEi | P0AGM9 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262570, 8 interactors |
STRINGi | 511145.b3654 |
Family & Domainsi
Sequence similaritiesi
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2233, Bacteria |
HOGENOMi | CLU_017959_8_0_6 |
InParanoidi | P0AGM9 |
PhylomeDBi | P0AGM9 |
Family and domain databases
InterProi | View protein in InterPro IPR006042, Xan_ur_permease IPR006043, Xant/urac/vitC |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
TIGRFAMsi | TIGR00801, ncs2, 1 hit |
PROSITEi | View protein in PROSITE PS01116, XANTH_URACIL_PERMASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AGM9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVSTLESEN AQPVAQTQNS ELIYRLEDRP PLPQTLFAAC QHLLAMFVAV
60 70 80 90 100
ITPALLICQA LGLPAQDTQH IISMSLFASG VASIIQIKAW GPVGSGLLSI
110 120 130 140 150
QGTSFNFVAP LIMGGTALKT GGADVPTMMA ALFGTLMLAS CTEMVISRVL
160 170 180 190 200
HLARRIITPL VSGVVVMIIG LSLIQVGLTS IGGGYAAMSD NTFGAPKNLL
210 220 230 240 250
LAGVVLALII LLNRQRNPYL RVASLVIAMA AGYALAWFMG MLPESNEPMT
260 270 280 290 300
QELIMVPTPL YYGLGIEWSL LLPLMLVFMI TSLETIGDIT ATSDVSEQPV
310 320 330 340 350
SGPLYMKRLK GGVLANGLNS FVSAVFNTFP NSCFGQNNGV IQLTGVASRY
360 370 380 390 400
VGFVVALMLI VLGLFPAVSG FVQHIPEPVL GGATLVMFGT IAASGVRIVS
410 420 430 440 450
REPLNRRAIL IIALSLAVGL GVSQQPLILQ FAPEWLKNLL SSGIAAGGIT
460
AIVLNLIFPP EKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62007.1 U00096 Genomic DNA Translation: AAC76678.1 AP009048 Genomic DNA Translation: BAE77639.1 X17499 Genomic DNA No translation available. |
PIRi | H65166 |
RefSeqi | NP_418111.1, NC_000913.3 WP_001295238.1, NZ_SSZK01000043.1 |
Genome annotation databases
EnsemblBacteriai | AAC76678; AAC76678; b3654 BAE77639; BAE77639; BAE77639 |
GeneIDi | 58389950 948172 |
KEGGi | ecj:JW3629 eco:b3654 |
PATRICi | fig|511145.12.peg.3774 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62007.1 U00096 Genomic DNA Translation: AAC76678.1 AP009048 Genomic DNA Translation: BAE77639.1 X17499 Genomic DNA No translation available. |
PIRi | H65166 |
RefSeqi | NP_418111.1, NC_000913.3 WP_001295238.1, NZ_SSZK01000043.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4262570, 8 interactors |
STRINGi | 511145.b3654 |
Protein family/group databases
TCDBi | 2.A.40.4.2, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family |
Proteomic databases
PaxDbi | P0AGM9 |
PRIDEi | P0AGM9 |
Protocols and materials databases
DNASUi | 948172 |
Genome annotation databases
EnsemblBacteriai | AAC76678; AAC76678; b3654 BAE77639; BAE77639; BAE77639 |
GeneIDi | 58389950 948172 |
KEGGi | ecj:JW3629 eco:b3654 |
PATRICi | fig|511145.12.peg.3774 |
Organism-specific databases
EchoBASEi | EB1180 |
Phylogenomic databases
eggNOGi | COG2233, Bacteria |
HOGENOMi | CLU_017959_8_0_6 |
InParanoidi | P0AGM9 |
PhylomeDBi | P0AGM9 |
Enzyme and pathway databases
BioCyci | EcoCyc:YICE-MONOMER MetaCyc:YICE-MONOMER |
Miscellaneous databases
PROi | PR:P0AGM9 |
Family and domain databases
InterProi | View protein in InterPro IPR006042, Xan_ur_permease IPR006043, Xant/urac/vitC |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
TIGRFAMsi | TIGR00801, ncs2, 1 hit |
PROSITEi | View protein in PROSITE PS01116, XANTH_URACIL_PERMASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XANP_ECOLI | |
Accessioni | P0AGM9Primary (citable) accession number: P0AGM9 Secondary accession number(s): P27432, Q2M7W7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families