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Entry version 118 (07 Oct 2020)
Sequence version 1 (20 Dec 2005)
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Protein

Uracil permease

Gene

uraA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transport of uracil in the cell.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei73Uracil; via amide nitrogen1 Publication1
Binding sitei241Uracil1 Publication1
Binding sitei289Uracil; via amide nitrogen1 Publication1
Binding sitei290Uracil1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:URAA-MONOMER
MetaCyc:URAA-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.40.1.1, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uracil permease
Alternative name(s):
Uracil transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uraA
Ordered Locus Names:b2497, JW2482
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13Cytoplasmic1 PublicationAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 37Helical1 PublicationAdd BLAST24
Topological domaini38 – 41Periplasmic1 Publication4
Transmembranei42 – 61Helical1 PublicationAdd BLAST20
Topological domaini62 – 64Cytoplasmic1 Publication3
Transmembranei65 – 81Discontinuously helical1 PublicationAdd BLAST17
Topological domaini82 – 89Periplasmic1 Publication8
Transmembranei90 – 110Helical1 PublicationAdd BLAST21
Topological domaini111 – 122Cytoplasmic1 PublicationAdd BLAST12
Transmembranei123 – 144Helical1 PublicationAdd BLAST22
Topological domaini145 – 155Periplasmic1 PublicationAdd BLAST11
Transmembranei156 – 171Helical1 PublicationAdd BLAST16
Topological domaini172 – 178Cytoplasmic1 Publication7
Transmembranei179 – 199Helical1 PublicationAdd BLAST21
Topological domaini200 – 224Periplasmic1 PublicationAdd BLAST25
Transmembranei225 – 248Helical1 PublicationAdd BLAST24
Topological domaini249 – 261Cytoplasmic1 PublicationAdd BLAST13
Transmembranei262 – 281Helical1 PublicationAdd BLAST20
Transmembranei282 – 298Discontinuously helical1 PublicationAdd BLAST17
Topological domaini299 – 301Cytoplasmic1 Publication3
Transmembranei302 – 319Helical1 PublicationAdd BLAST18
Topological domaini320 – 332Periplasmic1 PublicationAdd BLAST13
Transmembranei333 – 354Helical1 PublicationAdd BLAST22
Topological domaini355 – 365Cytoplasmic1 PublicationAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei366 – 401Discontinuously helical1 PublicationAdd BLAST36
Topological domaini402 – 429Cytoplasmic1 PublicationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi73F → A: Slightly decreased uracil uptake. 1 Publication1
Mutagenesisi241E → A: Abolishes uracil uptake. Abolishes uracil binding. 1 Publication1
Mutagenesisi245H → A: Abolishes uracil uptake. Abolishes uracil binding. 1 Publication1
Mutagenesisi288Y → A: No effect on uracil uptake. 1 Publication1
Mutagenesisi290E → A: Abolishes uracil uptake. Abolishes uracil binding. 1 Publication1
Mutagenesisi291N → A: Slightly decreased uracil uptake. 1 Publication1
Mutagenesisi342Y → A: Slightly decreased uracil uptake. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001659581 – 429Uracil permeaseAdd BLAST429

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AGM7

PRoteomics IDEntifications database

More...
PRIDEi
P0AGM7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261437, 11 interactors

Database of interacting proteins

More...
DIPi
DIP-11094N

Protein interaction database and analysis system

More...
IntActi
P0AGM7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b2497

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1429
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0AGM7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2233, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017959_1_2_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AGM7

KEGG Orthology (KO)

More...
KOi
K02824

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AGM7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029935, Uracil_permease
IPR006042, Xan_ur_permease
IPR006043, Xant/urac/vitC

The PANTHER Classification System

More...
PANTHERi
PTHR11119:SF49, PTHR11119:SF49, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00860, Xan_ur_permease, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00801, ncs2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01116, XANTH_URACIL_PERMASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AGM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRRAIGVSE RPPLLQTIPL SLQHLFAMFG ATVLVPVLFH INPATVLLFN
60 70 80 90 100
GIGTLLYLFI CKGKIPAYLG SSFAFISPVL LLLPLGYEVA LGGFIMCGVL
110 120 130 140 150
FCLVSFIVKK AGTGWLDVLF PPAAMGAIVA VIGLELAGVA AGMAGLLPAE
160 170 180 190 200
GQTPDSKTII ISITTLAVTV LGSVLFRGFL AIIPILIGVL VGYALSFAMG
210 220 230 240 250
IVDTTPIINA HWFALPTLYT PRFEWFAILT ILPAALVVIA EHVGHLVVTA
260 270 280 290 300
NIVKKDLLRD PGLHRSMFAN GLSTVISGFF GSTPNTTYGE NIGVMAITRV
310 320 330 340 350
YSTWVIGGAA IFAILLSCVG KLAAAIQMIP LPVMGGVSLL LYGVIGASGI
360 370 380 390 400
RVLIESKVDY NKAQNLILTS VILIIGVSGA KVNIGAAELK GMALATIVGI
410 420
GLSLIFKLIS VLRPEEVVLD AEDADITDK
Length:429
Mass (Da):45,060
Last modified:December 20, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18045190C960C674
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X73586 Genomic DNA Translation: CAA51992.1
U00096 Genomic DNA Translation: AAC75550.1
AP009048 Genomic DNA Translation: BAA16385.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A56265

NCBI Reference Sequences

More...
RefSeqi
NP_416992.1, NC_000913.3
WP_000198328.1, NZ_STEB01000011.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75550; AAC75550; b2497
BAA16385; BAA16385; BAA16385

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2482
eco:b2497

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.4242

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73586 Genomic DNA Translation: CAA51992.1
U00096 Genomic DNA Translation: AAC75550.1
AP009048 Genomic DNA Translation: BAA16385.1
PIRiA56265
RefSeqiNP_416992.1, NC_000913.3
WP_000198328.1, NZ_STEB01000011.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QE7X-ray2.78A1-429[»]
SMRiP0AGM7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4261437, 11 interactors
DIPiDIP-11094N
IntActiP0AGM7, 1 interactor
STRINGi511145.b2497

Protein family/group databases

TCDBi2.A.40.1.1, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

Proteomic databases

PaxDbiP0AGM7
PRIDEiP0AGM7

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
946978

Genome annotation databases

EnsemblBacteriaiAAC75550; AAC75550; b2497
BAA16385; BAA16385; BAA16385
GeneIDi946978
KEGGiecj:JW2482
eco:b2497
PATRICifig|1411691.4.peg.4242

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2050

Phylogenomic databases

eggNOGiCOG2233, Bacteria
HOGENOMiCLU_017959_1_2_6
InParanoidiP0AGM7
KOiK02824
PhylomeDBiP0AGM7

Enzyme and pathway databases

BioCyciEcoCyc:URAA-MONOMER
MetaCyc:URAA-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AGM7

Family and domain databases

InterProiView protein in InterPro
IPR029935, Uracil_permease
IPR006042, Xan_ur_permease
IPR006043, Xant/urac/vitC
PANTHERiPTHR11119:SF49, PTHR11119:SF49, 1 hit
PfamiView protein in Pfam
PF00860, Xan_ur_permease, 1 hit
TIGRFAMsiTIGR00801, ncs2, 1 hit
PROSITEiView protein in PROSITE
PS01116, XANTH_URACIL_PERMASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiURAA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AGM7
Secondary accession number(s): P33780
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: October 7, 2020
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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