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Entry version 107 (31 Jul 2019)
Sequence version 1 (20 Dec 2005)
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Protein

4-hydroxybenzoate octaprenyltransferase

Gene

ubiA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate (PubMed:4552989). Geranyldiphosphate (GPP), all-trans-farnesyldiphosphate (FPP) and all-trans-solanesyldiphosphate (SPP) are also accepted as side chain precursors (PubMed:8155731).2 Publications

Miscellaneous

The sdgG mutation, which suppresses a conditional mutation in dnaG (DNA primase), has been localized to one of the ubiA, ubiC or yjbI genes.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation2 PublicationsNote: Can also use Mn2+ and Co2+ with lower efficiency.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The reaction is stimulated by 0.01% CHAPS, but strongly inhibited by sodiumdeoxycholate, Tween 80 and Triton X-100.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=255 µM for GPP1 Publication
  2. KM=22 µM for FPP1 Publication
  3. KM=31 µM for SPP1 Publication

    pH dependencei

    Optimum pH is 7.8.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: ubiquinone biosynthesis

    This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation1 Publication
    View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    • ubiquinone biosynthetic process Source: EcoCyc

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    Biological processUbiquinone biosynthesis
    LigandMagnesium

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-MONOMER
    ECOL316407:JW4000-MONOMER
    MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-MONOMER

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00232

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    4-hydroxybenzoate octaprenyltransferase1 PublicationUniRule annotation (EC:2.5.1.39UniRule annotation1 Publication)
    Alternative name(s):
    4-HB polyprenyltransferase1 PublicationUniRule annotation
    PHB octaprenyl transferase1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ubiA1 PublicationUniRule annotation
    Synonyms:cyr
    Ordered Locus Names:b4040, JW4000
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    Escherichia coli strain K12 genome database

    More...
    EcoGenei
    EG11370 ubiA

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 22Periplasmic1 PublicationAdd BLAST22
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 43HelicalUniRule annotationAdd BLAST21
    Topological domaini44 – 45Cytoplasmic1 Publication2
    Transmembranei46 – 66HelicalUniRule annotationAdd BLAST21
    Topological domaini67 – 99Periplasmic1 PublicationAdd BLAST33
    Transmembranei100 – 119HelicalUniRule annotationAdd BLAST20
    Topological domaini120 – 140Cytoplasmic1 PublicationAdd BLAST21
    Transmembranei141 – 161HelicalUniRule annotationAdd BLAST21
    Topological domaini162Periplasmic1 Publication1
    Transmembranei163 – 183HelicalUniRule annotationAdd BLAST21
    Topological domaini184 – 212Cytoplasmic1 PublicationAdd BLAST29
    Transmembranei213 – 233HelicalUniRule annotationAdd BLAST21
    Transmembranei234 – 254HelicalUniRule annotationAdd BLAST21
    Topological domaini255 – 267Cytoplasmic1 PublicationAdd BLAST13
    Transmembranei268 – 288HelicalUniRule annotationAdd BLAST21
    Topological domaini289 – 290Periplasmic1 Publication2

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Mutant is unable to convert 4-hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate and is ubiquinone-deficient.1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001628901 – 2904-hydroxybenzoate octaprenyltransferaseAdd BLAST290

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P0AGK1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P0AGK1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Expression is slightly repressed by glucose.1 Publication

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4259714, 333 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b4040

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the UbiA prenyltransferase family.UniRule annotationCurated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105C4G Bacteria
    COG0382 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000003696

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P0AGK1

    KEGG Orthology (KO)

    More...
    KOi
    K03179

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P0AGK1

    Family and domain databases

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01635 UbiA, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006370 HB_polyprenyltransferase-like
    IPR039653 Prenyltransferase
    IPR000537 UbiA_prenyltransferase
    IPR030470 UbiA_prenylTrfase_CS

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11048 PTHR11048, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01040 UbiA, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01474 ubiA_proteo, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00943 UBIA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P0AGK1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEWSLTQNKL LAFHRLMRTD KPIGALLLLW PTLWALWVAT PGVPQLWILA
    60 70 80 90 100
    VFVAGVWLMR AAGCVVNDYA DRKFDGHVKR TANRPLPSGA VTEKEARALF
    110 120 130 140 150
    VVLVLISFLL VLTLNTMTIL LSIAALALAW VYPFMKRYTH LPQVVLGAAF
    160 170 180 190 200
    GWSIPMAFAA VSESVPLSCW LMFLANILWA VAYDTQYAMV DRDDDVKIGI
    210 220 230 240 250
    KSTAILFGQY DKLIIGILQI GVLALMAIIG ELNGLGWGYY WSILVAGALF
    260 270 280 290
    VYQQKLIANR EREACFKAFM NNNYVGLVLF LGLAMSYWHF
    Length:290
    Mass (Da):32,512
    Last modified:December 20, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF10FED1D7A30E115
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M93136 Genomic DNA Translation: AAA24712.1
    M93413 Genomic DNA Translation: AAA24717.1
    X66619 Genomic DNA Translation: CAA47182.1
    X57434 Genomic DNA Translation: CAA40682.1
    X69522 Genomic DNA Translation: CAA49270.1
    DQ087228 Genomic DNA Translation: AAY88960.1
    U00006 Genomic DNA Translation: AAC43134.1
    U00096 Genomic DNA Translation: AAC77010.1
    AP009048 Genomic DNA Translation: BAE78042.1
    M96268 Unassigned DNA Translation: AAA17028.1
    X63407 Genomic DNA Translation: CAA45003.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    JC2316

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_418464.1, NC_000913.3
    WP_000455227.1, NZ_SSZK01000016.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC77010; AAC77010; b4040
    BAE78042; BAE78042; BAE78042

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    948540

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW4000
    eco:b4040

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.2668

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M93136 Genomic DNA Translation: AAA24712.1
    M93413 Genomic DNA Translation: AAA24717.1
    X66619 Genomic DNA Translation: CAA47182.1
    X57434 Genomic DNA Translation: CAA40682.1
    X69522 Genomic DNA Translation: CAA49270.1
    DQ087228 Genomic DNA Translation: AAY88960.1
    U00006 Genomic DNA Translation: AAC43134.1
    U00096 Genomic DNA Translation: AAC77010.1
    AP009048 Genomic DNA Translation: BAE78042.1
    M96268 Unassigned DNA Translation: AAA17028.1
    X63407 Genomic DNA Translation: CAA45003.1
    PIRiJC2316
    RefSeqiNP_418464.1, NC_000913.3
    WP_000455227.1, NZ_SSZK01000016.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi4259714, 333 interactors
    STRINGi511145.b4040

    Proteomic databases

    PaxDbiP0AGK1
    PRIDEiP0AGK1

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAAC77010; AAC77010; b4040
    BAE78042; BAE78042; BAE78042
    GeneIDi948540
    KEGGiecj:JW4000
    eco:b4040
    PATRICifig|1411691.4.peg.2668

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB1344
    EcoGeneiEG11370 ubiA

    Phylogenomic databases

    eggNOGiENOG4105C4G Bacteria
    COG0382 LUCA
    HOGENOMiHOG000003696
    InParanoidiP0AGK1
    KOiK03179
    PhylomeDBiP0AGK1

    Enzyme and pathway databases

    UniPathwayiUPA00232
    BioCyciEcoCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-MONOMER
    ECOL316407:JW4000-MONOMER
    MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P0AGK1

    Family and domain databases

    HAMAPiMF_01635 UbiA, 1 hit
    InterProiView protein in InterPro
    IPR006370 HB_polyprenyltransferase-like
    IPR039653 Prenyltransferase
    IPR000537 UbiA_prenyltransferase
    IPR030470 UbiA_prenylTrfase_CS
    PANTHERiPTHR11048 PTHR11048, 1 hit
    PfamiView protein in Pfam
    PF01040 UbiA, 1 hit
    TIGRFAMsiTIGR01474 ubiA_proteo, 1 hit
    PROSITEiView protein in PROSITE
    PS00943 UBIA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBIA_ECOLI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AGK1
    Secondary accession number(s): P26601, Q2M6R4, Q4JHR7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: July 31, 2019
    This is version 107 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
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