The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P0AGH5 (SAPC_ECOLI)
Protein
Putrescine export system permease protein SapC
Gene
sapC
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides.
1 PublicationGO - Molecular functioni
- putrescine transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- peptide transport Source: ComplexPortal
- putrescine transport Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:SAPC-MONOMER |
BRENDAi | 7.6.2.11, 2026 |
Protein family/group databases
TCDBi | 3.A.1.5.42, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Putrescine export system permease protein SapCCurated |
Gene namesi | Name:sapC Ordered Locus Names:b1292, JW1285 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing Source: ComplexPortal
- plasma membrane Source: EcoCyc
Other locations
- membrane Source: ComplexPortal
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 49 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 50 – 98 | PeriplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 99 – 119 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 120 – 133 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 134 – 154 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 155 – 196 | PeriplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 197 – 217 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 218 – 222 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 223 – 243 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 244 – 257 | PeriplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 258 – 278 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 279 – 296 | CytoplasmicSequence analysis1 PublicationAdd BLAST | 18 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Single mutation, decreased extracellular putrescine, in an sapBCDF operon deletion no change in resistance to antimicrobial peptide LL-37.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060163 | 1 – 296 | Putrescine export system permease protein SapCAdd BLAST | 296 |
Proteomic databases
jPOSTi | P0AGH5 |
PaxDbi | P0AGH5 |
PRIDEi | P0AGH5 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263003, 195 interactors |
ComplexPortali | CPX-4422, Putative peptide ABC transporter |
DIPi | DIP-10824N |
IntActi | P0AGH5, 1 interactor |
STRINGi | 511145.b1292 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 99 – 284 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 186 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG4171, Bacteria |
HOGENOMi | CLU_028518_1_1_6 |
InParanoidi | P0AGH5 |
OMAi | WFAVLPN |
PhylomeDBi | P0AGH5 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR000515, MetI-like IPR035906, MetI-like_sf IPR025966, OppC_N |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit PF12911, OppC_N, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AGH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPYDSVYSEK RPPGTLRTAW RKFYSDASAM VGLYGCAGLA VLCIFGGWFA
60 70 80 90 100
PYGIDQQFLG YQLLPPSWSR YGEVSFFLGT DDLGRDVLSR LLSGAAPTVG
110 120 130 140 150
GAFVVTLAAT ICGLVLGTFA GATHGLRSAV LNHILDTLLA IPSLLLAIIV
160 170 180 190 200
VAFAGPSLSH AMFAVWLALL PRMVRSIYSM VHDELEKEYV IAARLDGAST
210 220 230 240 250
LNILWFAVMP NITAGLVTEI TRALSMAILD IAALGFLDLG AQLPSPEWGA
260 270 280 290
MLGDALELIY VAPWTVMLPG AAIMISVLLV NLLGDGVRRA IIAGVE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97282 Genomic DNA Translation: CAA65939.1 U00096 Genomic DNA Translation: AAC74374.1 AP009048 Genomic DNA Translation: BAA14845.1 |
PIRi | G64877 |
RefSeqi | NP_415808.1, NC_000913.3 WP_001146163.1, NZ_STEB01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAC74374; AAC74374; b1292 BAA14845; BAA14845; BAA14845 |
GeneIDi | 66674881 945266 |
KEGGi | ecj:JW1285 eco:b1292 |
PATRICi | fig|1411691.4.peg.987 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97282 Genomic DNA Translation: CAA65939.1 U00096 Genomic DNA Translation: AAC74374.1 AP009048 Genomic DNA Translation: BAA14845.1 |
PIRi | G64877 |
RefSeqi | NP_415808.1, NC_000913.3 WP_001146163.1, NZ_STEB01000005.1 |
3D structure databases
AlphaFoldDBi | P0AGH5 |
SMRi | P0AGH5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263003, 195 interactors |
ComplexPortali | CPX-4422, Putative peptide ABC transporter |
DIPi | DIP-10824N |
IntActi | P0AGH5, 1 interactor |
STRINGi | 511145.b1292 |
Protein family/group databases
TCDBi | 3.A.1.5.42, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P0AGH5 |
PaxDbi | P0AGH5 |
PRIDEi | P0AGH5 |
Genome annotation databases
EnsemblBacteriai | AAC74374; AAC74374; b1292 BAA14845; BAA14845; BAA14845 |
GeneIDi | 66674881 945266 |
KEGGi | ecj:JW1285 eco:b1292 |
PATRICi | fig|1411691.4.peg.987 |
Organism-specific databases
EchoBASEi | EB4157 |
Phylogenomic databases
eggNOGi | COG4171, Bacteria |
HOGENOMi | CLU_028518_1_1_6 |
InParanoidi | P0AGH5 |
OMAi | WFAVLPN |
PhylomeDBi | P0AGH5 |
Enzyme and pathway databases
BioCyci | EcoCyc:SAPC-MONOMER |
BRENDAi | 7.6.2.11, 2026 |
Miscellaneous databases
PROi | PR:P0AGH5 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR000515, MetI-like IPR035906, MetI-like_sf IPR025966, OppC_N |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit PF12911, OppC_N, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SAPC_ECOLI | |
Accessioni | P0AGH5Primary (citable) accession number: P0AGH5 Secondary accession number(s): Q47624 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | May 25, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families