UniProtKB - P0AGG4 (THIO2_ECOLI)
Protein
Thioredoxin 2
Gene
trxC
Organism
Escherichia coli (strain K12)
Status
Functioni
Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin.
Catalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 5 – 18 | Sequence analysisAdd BLAST | 14 |
GO - Molecular functioni
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Source: GO_Central
- protein disulfide oxidoreductase activity Source: EcoCyc
- protein-disulfide reductase activity Source: CACAO
- zinc ion binding Source: EcoCyc
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- glycerol ether metabolic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Electron transport, Transport |
Ligand | Metal-binding, NAD, Zinc |
Enzyme and pathway databases
BioCyci | EcoCyc:RED-THIOREDOXIN2-MONOMER MetaCyc:RED-THIOREDOXIN2-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Thioredoxin 2 (EC:1.8.1.8)Short name: Trx-2 Alternative name(s): Protein-disulfide reductase |
Gene namesi | Name:trxC Synonyms:yfiG Ordered Locus Names:b2582, JW2566 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120102 | 1 – 139 | Thioredoxin 2Add BLAST | 139 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 64 ↔ 67 | Redox-activePROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | P0AGG4 |
PaxDbi | P0AGG4 |
PRIDEi | P0AGG4 |
Interactioni
Binary interactionsi
P0AGG4
With | #Exp. | IntAct |
---|---|---|
murD [P14900] | 2 | EBI-549392,EBI-554780 |
Protein-protein interaction databases
BioGRIDi | 4263420, 20 interactors 851399, 2 interactors |
DIPi | DIP-48115N |
IntActi | P0AGG4, 26 interactors |
STRINGi | 511145.b2582 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 139 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 114 |
Sequence similaritiesi
Belongs to the thioredoxin family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 5 – 18 | Sequence analysisAdd BLAST | 14 |
Keywords - Domaini
Redox-active center, Zinc-fingerPhylogenomic databases
eggNOGi | COG3118, Bacteria |
HOGENOMi | CLU_090389_10_0_6 |
InParanoidi | P0AGG4 |
PhylomeDBi | P0AGG4 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AGG4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTVCTHCQA INRIPDDRIE DAAKCGRCGH DLFDGEVINA TGETLDKLLK
60 70 80 90 100
DDLPVVIDFW APWCGPCRNF APIFEDVAQE RSGKVRFVKV NTEAERELSS
110 120 130
RFGIRSIPTI MIFKNGQVVD MLNGAVPKAP FDSWLNESL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U85942 Genomic DNA Translation: AAB88587.1 U00096 Genomic DNA Translation: AAC75635.1 AP009048 Genomic DNA Translation: BAA16469.2 D13169 Genomic DNA No translation available. |
PIRi | E65036 |
RefSeqi | NP_417077.1, NC_000913.3 WP_001098726.1, NZ_STEB01000011.1 |
Genome annotation databases
EnsemblBacteriai | AAC75635; AAC75635; b2582 BAA16469; BAA16469; BAA16469 |
GeneIDi | 58460999 947062 |
KEGGi | ecj:JW2566 eco:b2582 |
PATRICi | fig|1411691.4.peg.4152 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U85942 Genomic DNA Translation: AAB88587.1 U00096 Genomic DNA Translation: AAC75635.1 AP009048 Genomic DNA Translation: BAA16469.2 D13169 Genomic DNA No translation available. |
PIRi | E65036 |
RefSeqi | NP_417077.1, NC_000913.3 WP_001098726.1, NZ_STEB01000011.1 |
3D structure databases
SMRi | P0AGG4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263420, 20 interactors 851399, 2 interactors |
DIPi | DIP-48115N |
IntActi | P0AGG4, 26 interactors |
STRINGi | 511145.b2582 |
Proteomic databases
jPOSTi | P0AGG4 |
PaxDbi | P0AGG4 |
PRIDEi | P0AGG4 |
Genome annotation databases
EnsemblBacteriai | AAC75635; AAC75635; b2582 BAA16469; BAA16469; BAA16469 |
GeneIDi | 58460999 947062 |
KEGGi | ecj:JW2566 eco:b2582 |
PATRICi | fig|1411691.4.peg.4152 |
Organism-specific databases
EchoBASEi | EB1833 |
Phylogenomic databases
eggNOGi | COG3118, Bacteria |
HOGENOMi | CLU_090389_10_0_6 |
InParanoidi | P0AGG4 |
PhylomeDBi | P0AGG4 |
Enzyme and pathway databases
BioCyci | EcoCyc:RED-THIOREDOXIN2-MONOMER MetaCyc:RED-THIOREDOXIN2-MONOMER |
Miscellaneous databases
PROi | PR:P0AGG4 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THIO2_ECOLI | |
Accessioni | P0AGG4Primary (citable) accession number: P0AGG4 Secondary accession number(s): P33636 P77001 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families