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UniProtKB - P0AGA2 (SECY_ECOLI)

Entry version 124 (23 Feb 2022)
Sequence version 1 (21 Jul 1986)
Previous versions | rss
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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. SecY is required to insert newly synthesized SecY into the inner membrane. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true, overexpression also results in FtsH-mediated degradation of SecY.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:SECY

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.5.1.1, the general secretory pathway (sec) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein translocase subunit SecY
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secY
Synonyms:prlA
Ordered Locus Names:b3300, JW3262
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 22CytoplasmicCuratedAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 35Helical; Name=1CuratedAdd BLAST13
Topological domaini36 – 60PeriplasmicBy similarityAdd BLAST25
Transmembranei61 – 96Discontinuously helical; Name=2By similarityAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei61 – 70Helical; Name=Helix 2ACurated10
Intramembranei71 – 76Curated6
Intramembranei77 – 96Helical; Name=Helix 2BCuratedAdd BLAST20
Topological domaini97 – 115CytoplasmicCuratedAdd BLAST19
Transmembranei116 – 131Helical; Name=3CuratedAdd BLAST16
Topological domaini132 – 164PeriplasmicCuratedAdd BLAST33
Transmembranei165 – 178Helical; Name=4CuratedAdd BLAST14
Topological domaini179 – 183CytoplasmicCurated5
Transmembranei184 – 200Helical; Name=5CuratedAdd BLAST17
Topological domaini201 – 223PeriplasmicCuratedAdd BLAST23
Transmembranei224 – 237Helical; Name=6CuratedAdd BLAST14
Topological domaini238 – 273CytoplasmicCuratedAdd BLAST36
Transmembranei274 – 287Helical; Name=7CuratedAdd BLAST14
Topological domaini288 – 313PeriplasmicCuratedAdd BLAST26
Transmembranei314 – 329Helical; Name=8CuratedAdd BLAST16
Topological domaini330 – 380CytoplasmicCuratedAdd BLAST51
Transmembranei381 – 395Helical; Name=9CuratedAdd BLAST15
Topological domaini396PeriplasmicCurated1
Transmembranei397 – 413Helical; Name=10CuratedAdd BLAST17
Topological domaini414 – 443CytoplasmicCuratedAdd BLAST30

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40P → S in secY100; temperature-sensitive. 1
Mutagenesisi60 – 74Missing : Some loss of viability, supports protein translocation; strongly suppresses defective and missing signal sequences; transient transmembrane channels open. 2 PublicationsAdd BLAST15
Mutagenesisi65 – 70Missing : Grows almost as well as wild-type, supports protein translocation; strongly suppresses defective and missing signal sequences; transient transmembrane channels open. 2 Publications6
Mutagenesisi67F → C in prlA3; altered signal sequence interaction, transient channel opening and closing in presence of oxidant; massive ion flux when cross-linked to SecE C-120 mutation. 1 Publication1
Mutagenesisi167G → E in secY100; temperature-sensitive. 1
Mutagenesisi240G → D in secY24; temperature-sensitive at 42 degrees Celsius, impairs interaction with SecE even at 30 degrees in vitro. 1 Publication1
Mutagenesisi282S → R in prlA401; altered signal sequence interaction, transient transmembrane channels open. 1
Mutagenesisi286F → Y in prlA4-1; altered signal sequence interaction. 1
Mutagenesisi287P → L in secY161; altered signal sequence interaction. 1
Mutagenesisi290I → T in secY121; altered signal sequence interaction. 1
Mutagenesisi357R → H in secY39; cold-sensitive. 1
Mutagenesisi363A → S in secY40; cold-sensitive. 1
Mutagenesisi408I → N in prlA4-2; altered signal sequence interaction. 1 Publication1
Mutagenesisi424 – 443Missing : No longer complements secY24, a temperature-sensitive secY mutation. 1 PublicationAdd BLAST20

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001317211 – 443Protein translocase subunit SecYAdd BLAST443

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

SecY that is not part of the protein translocation apparatus is degraded by FtsH. Also degraded by FtsH when the SecYEG complex is jammed, or upon treatment with antibiotics that block translation elongation such as chloramphenicol.

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0AGA2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0AGA2

PRoteomics IDEntifications database

More...PRIDEi		P0AGA2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins.

Interacts with the ribosome.

Interacts with SecDF-YajC and YidC; YidC interacts with nascent inner membrane proteins after SecY. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL) (PubMed:27435098). The stoichiometry of the super complex may be SecYEG:YidC:SecDF 4:3:1, YajC is in the reconstituted complex (with SecDF) but as no antibody is available it could not be quantified (PubMed:27435098). SecY probably contacts the 23S rRNA and possibly also ribosomal protein L23 during ribosome docking. A single SecY molecule forms the translocating pore, although interaction with SecA may require oligomers.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4263404, 365 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1095, Holo-translocon SecYEG-SecDF-YajC-YidC complex
CPX-1096, Protein-conducting channel SecYEG complex

Database of interacting proteins

More...DIPi		DIP-59302N

Protein interaction database and analysis system

More...IntActi		P0AGA2, 5 interactors

STRING: functional protein association networks

More...STRINGi		511145.b3300

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0AGA2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P0AGA2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0201, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030313_0_2_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0AGA2

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0AGA2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.3370.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01465, SecY, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026593, SecY
IPR002208, SecY/SEC61-alpha
IPR030659, SecY_CS
IPR023201, SecY_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR10906, PTHR10906, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00344, SecY, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF004557, SecY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103491, SSF103491, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00967, 3a0501s007, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00755, SECY_1, 1 hit
PS00756, SECY_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AGA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKQPGLDFQ SAKGGLGELK RRLLFVIGAL IVFRIGSFIP IPGIDAAVLA 
        60         70         80         90        100
KLLEQQRGTI IEMFNMFSGG ALSRASIFAL GIMPYISASI IIQLLTVVHP 
       110        120        130        140        150
TLAEIKKEGE SGRRKISQYT RYGTLVLAIF QSIGIATGLP NMPGMQGLVI 
       160        170        180        190        200
NPGFAFYFTA VVSLVTGTMF LMWLGEQITE RGIGNGISII IFAGIVAGLP 
       210        220        230        240        250
PAIAHTIEQA RQGDLHFLVL LLVAVLVFAV TFFVVFVERG QRRIVVNYAK 
       260        270        280        290        300
RQQGRRVYAA QSTHLPLKVN MAGVIPAIFA SSIILFPATI ASWFGGGTGW 
       310        320        330        340        350
NWLTTISLYL QPGQPLYVLL YASAIIFFCF FYTALVFNPR ETADNLKKSG 
       360        370        380        390        400
AFVPGIRPGE QTAKYIDKVM TRLTLVGALY ITFICLIPEF MRDAMKVPFY 
       410        420        430        440 
FGGTSLLIVV VVIMDFMAQV QTLMMSSQYE SALKKANLKG YGR
Length:443
Mass (Da):48,512
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i711CA63CD8809763
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X01563 Genomic DNA Translation: CAA25725.1
U18997 Genomic DNA Translation: AAA58097.1
U00096 Genomic DNA Translation: AAC76325.1
AP009048 Genomic DNA Translation: BAE77991.1

Protein sequence database of the Protein Information Resource

More...PIRi		A04473, QQECSY

NCBI Reference Sequences

More...RefSeqi		NP_417759.1, NC_000913.3
WP_001118861.1, NZ_STEB01000038.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76325; AAC76325; b3300
BAE77991; BAE77991; BAE77991

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67415341
947799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW3262
eco:b3300

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.3431

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01563 Genomic DNA Translation: CAA25725.1
U18997 Genomic DNA Translation: AAA58097.1
U00096 Genomic DNA Translation: AAC76325.1
AP009048 Genomic DNA Translation: BAE77991.1
PIRiA04473, QQECSY
RefSeqiNP_417759.1, NC_000913.3
WP_001118861.1, NZ_STEB01000038.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AKHelectron microscopy14.90B/Y1-436[»]
2AKIelectron microscopy14.90B/Y1-436[»]
3J45electron microscopy9.50y6-440[»]
3J46electron microscopy10.10y6-440[»]
4V6Melectron microscopy-A8-442[»]
5ABBelectron microscopy8.00A1-443[»]
5GAEelectron microscopy3.33g1-443[»]
5MG3electron microscopy14.00Y1-443[»]
5NCOelectron microscopy4.80g14-429[»]
6R7Lelectron microscopy6.00Y1-443[»]
SMRiP0AGA2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4263404, 365 interactors
ComplexPortaliCPX-1095, Holo-translocon SecYEG-SecDF-YajC-YidC complex
CPX-1096, Protein-conducting channel SecYEG complex
DIPiDIP-59302N
IntActiP0AGA2, 5 interactors
STRINGi511145.b3300

Protein family/group databases

TCDBi3.A.5.1.1, the general secretory pathway (sec) family

Proteomic databases

jPOSTiP0AGA2
PaxDbiP0AGA2
PRIDEiP0AGA2

Genome annotation databases

EnsemblBacteriaiAAC76325; AAC76325; b3300
BAE77991; BAE77991; BAE77991
GeneIDi67415341
947799
KEGGiecj:JW3262
eco:b3300
PATRICifig|1411691.4.peg.3431

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0759

Phylogenomic databases

eggNOGiCOG0201, Bacteria
HOGENOMiCLU_030313_0_2_6
InParanoidiP0AGA2
PhylomeDBiP0AGA2

Enzyme and pathway databases

BioCyciEcoCyc:SECY

Miscellaneous databases

EvolutionaryTraceiP0AGA2

Protein Ontology

More...PROi		PR:P0AGA2

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465, SecY, 1 hit
InterProiView protein in InterPro
IPR026593, SecY
IPR002208, SecY/SEC61-alpha
IPR030659, SecY_CS
IPR023201, SecY_dom_sf
PANTHERiPTHR10906, PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344, SecY, 1 hit
PIRSFiPIRSF004557, SecY, 1 hit
SUPFAMiSSF103491, SSF103491, 1 hit
TIGRFAMsiTIGR00967, 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755, SECY_1, 1 hit
PS00756, SECY_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSECY_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AGA2
Secondary accession number(s): P03844, Q2M6W5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 23, 2022
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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