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UniProtKB - P0AFU2 (YFBS_ECOLI)

Entry version 111 (07 Apr 2021)
Sequence version 1 (20 Dec 2005)
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Protein

Uncharacterized transporter YfbS

Gene

yfbS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G7186-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.47.4.8, the divalent anion:na(+) symporter (dass) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized transporter YfbS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yfbS
Ordered Locus Names:b2292, JW2289
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Transmembranei543 – 563HelicalSequence analysisAdd BLAST21
Transmembranei588 – 608HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001725031 – 610Uncharacterized transporter YfbSAdd BLAST610

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0AFU2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0AFU2

PRoteomics IDEntifications database

More...PRIDEi		P0AFU2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262968, 215 interactors

Database of interacting proteins

More...DIPi		DIP-48033N

Protein interaction database and analysis system

More...IntActi		P0AFU2, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b2292

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini218 – 307RCK C-terminal 1PROSITE-ProRule annotationAdd BLAST90
Domaini314 – 398RCK C-terminal 2PROSITE-ProRule annotationAdd BLAST85

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CitM (TC 2.A.11) transporter family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0471, Bacteria
COG0490, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005170_6_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0AFU2

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0AFU2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.1450, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004680, Cit_transptr-like_dom
IPR031312, Na/sul_symport_CS
IPR006037, RCK_C
IPR036721, RCK_C_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03600, CitMHS, 2 hits
PF02080, TrkA_C, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF116726, SSF116726, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01271, NA_SULFATE, 1 hit
PS51202, RCK_C, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AFU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGELIWVLS LLAVAIVLFA TGRVRMDAVA LFVIVAFALS GTLTVPEVFS 
        60         70         80         90        100
GFSDPNVVLI AALFIIGDGL VRTGVATVMG TWLVKVAGNS EIKMLVLLML 
       110        120        130        140        150
TVAGLGAFMS STGVVAIFIP VVLSVAMRMQ TSPSRLMMPL SFAGLISGMM 
       160        170        180        190        200
TLVATPPNLV VNSELLREGY HGFSFFSVTP IGLVVLVLGI LYMLVMRFML 
       210        220        230        240        250
KGDTQTPQRE GWTRRTFRDL IREYRLTGRA RRLAIRPGSP MIGQRLDDLK 
       260        270        280        290        300
LRERYGANVI GVERWRRFRR VIVNVNGVSE FRARDVLLID MSAADVDLRQ 
       310        320        330        340        350
FCSEQLLEPM VLRGEYFSDQ ALDVGMAEIS LIPESELIGK SVREIGFRTR 
       360        370        380        390        400
YGLNVVGLKR NGVALEGSLA DEPLLLGDII LVVGNWKLIG MLAKQGRDFV 
       410        420        430        440        450
ALNLPEEVSE ASPAHSQAPH AIFCLVLMVA LMLTDEIPNP VAAIIACLLM 
       460        470        480        490        500
GKFRCIDAES AYKSIHWPSI ILIVGMMPFA VALQKTGGVA LAVKGLMDIG 
       510        520        530        540        550
GGYGPHMMLG CLFVLSAVIG LFISNTATAV LMAPIALAAA KTMGVSPYPF 
       560        570        580        590        600
AMVVAMAASA AFMTPVSSPV NTLVLGPGNY SFSDFVKLGV PFTIIVMAVC 
       610
VVMIPMLFPF
Length:610
Mass (Da):65,872
Last modified:December 20, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57100587B0F54C9F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75352.1
AP009048 Genomic DNA Translation: BAA16128.1

Protein sequence database of the Protein Information Resource

More...PIRi		B65001

NCBI Reference Sequences

More...RefSeqi		NP_416795.1, NC_000913.3
WP_001012899.1, NZ_STEB01000008.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75352; AAC75352; b2292
BAA16128; BAA16128; BAA16128

Database of genes from NCBI RefSeq genomes

More...GeneIDi		58462917
946766

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2289
eco:b2292

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.4443

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75352.1
AP009048 Genomic DNA Translation: BAA16128.1
PIRiB65001
RefSeqiNP_416795.1, NC_000913.3
WP_001012899.1, NZ_STEB01000008.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4262968, 215 interactors
DIPiDIP-48033N
IntActiP0AFU2, 1 interactor
STRINGi511145.b2292

Protein family/group databases

TCDBi2.A.47.4.8, the divalent anion:na(+) symporter (dass) family

Proteomic databases

jPOSTiP0AFU2
PaxDbiP0AFU2
PRIDEiP0AFU2

Genome annotation databases

EnsemblBacteriaiAAC75352; AAC75352; b2292
BAA16128; BAA16128; BAA16128
GeneIDi58462917
946766
KEGGiecj:JW2289
eco:b2292
PATRICifig|1411691.4.peg.4443

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB3856

Phylogenomic databases

eggNOGiCOG0471, Bacteria
COG0490, Bacteria
HOGENOMiCLU_005170_6_1_6
InParanoidiP0AFU2
PhylomeDBiP0AFU2

Enzyme and pathway databases

BioCyciEcoCyc:G7186-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0AFU2

Family and domain databases

Gene3Di3.30.70.1450, 2 hits
InterProiView protein in InterPro
IPR004680, Cit_transptr-like_dom
IPR031312, Na/sul_symport_CS
IPR006037, RCK_C
IPR036721, RCK_C_sf
PfamiView protein in Pfam
PF03600, CitMHS, 2 hits
PF02080, TrkA_C, 2 hits
SUPFAMiSSF116726, SSF116726, 2 hits
PROSITEiView protein in PROSITE
PS01271, NA_SULFATE, 1 hit
PS51202, RCK_C, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYFBS_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AFU2
Secondary accession number(s): P76935, P77741
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: April 7, 2021
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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