UniProtKB - P0AFR9 (YDCV_ECOLI)
Protein
Inner membrane ABC transporter permease protein YdcV
Gene
ydcV
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in natural transformation (PubMed:26826386). Probably part of the ABC transporter complex YdcSTUV. Probably responsible for the translocation of the substrate across the membrane. During natural transformation, may serve as the channel for dsDNA uptake (Probable).1 Publication1 Publication
GO - Biological processi
- DNA import into cell involved in transformation Source: EcoCyc
- transmembrane transport Source: InterPro
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YDCV-MONOMER MetaCyc:YDCV-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.11.9, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Inner membrane ABC transporter permease protein YdcVCurated |
Gene namesi | Name:ydcV Ordered Locus Names:b1443, JW1438 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | CytoplasmicCuratedAdd BLAST | 12 | |
Transmembranei | 13 – 33 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 34 – 70 | PeriplasmicCuratedAdd BLAST | 37 | |
Transmembranei | 71 – 91 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 92 – 100 | CytoplasmicCurated | 9 | |
Transmembranei | 101 – 121 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 122 – 128 | PeriplasmicCurated | 7 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 150 – 189 | CytoplasmicCuratedAdd BLAST | 40 | |
Transmembranei | 190 – 210 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 211 – 236 | PeriplasmicCuratedAdd BLAST | 26 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 264 | Cytoplasmic1 Publication | 7 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Natural transformation rate of the mutant is reduced by 3.3-9.5 folds. Mutation does not affect chemical transformation.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060243 | 1 – 264 | Inner membrane ABC transporter permease protein YdcVAdd BLAST | 264 |
Proteomic databases
PaxDbi | P0AFR9 |
PRIDEi | P0AFR9 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260190, 44 interactors |
ComplexPortali | CPX-4446, YdcSTUV ABC transporter complex |
STRINGi | 511145.b1443 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 252 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 188 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1177, Bacteria |
HOGENOMi | CLU_016047_3_0_6 |
InParanoidi | P0AFR9 |
PhylomeDBi | P0AFR9 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AFR9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSERAPFFL KLAAWGGVVF LHFPILIIAA YAFNTEDAAF SFPPQGLTLR
60 70 80 90 100
WFSVAAQRSD ILDAVTLSLK VAALATLIAL VLGTLAAAAL WRRDFFGKNA
110 120 130 140 150
ISLLLLLPIA LPGIVTGLAL LTAFKTINLE PGFFTIVVGH ATFCVVVVFN
160 170 180 190 200
NVIARFRRTS WSLVEASMDL GANGWQTFRY VVLPNLSSAL LAGGMLAFAL
210 220 230 240 250
SFDEIIVTTF TAGHERTLPL WLLNQLGRPR DVPVTNVVAL LVMLVTTLPI
260
LGAWWLTREG DNGQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74525.1 AP009048 Genomic DNA Translation: BAA15072.1 |
PIRi | F64896 |
RefSeqi | NP_415960.1, NC_000913.3 WP_000555458.1, NZ_SSZK01000021.1 |
Genome annotation databases
EnsemblBacteriai | AAC74525; AAC74525; b1443 BAA15072; BAA15072; BAA15072 |
GeneIDi | 945903 |
KEGGi | ecj:JW1438 eco:b1443 |
PATRICi | fig|1411691.4.peg.825 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74525.1 AP009048 Genomic DNA Translation: BAA15072.1 |
PIRi | F64896 |
RefSeqi | NP_415960.1, NC_000913.3 WP_000555458.1, NZ_SSZK01000021.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260190, 44 interactors |
ComplexPortali | CPX-4446, YdcSTUV ABC transporter complex |
STRINGi | 511145.b1443 |
Protein family/group databases
TCDBi | 3.A.1.11.9, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P0AFR9 |
PRIDEi | P0AFR9 |
Genome annotation databases
EnsemblBacteriai | AAC74525; AAC74525; b1443 BAA15072; BAA15072; BAA15072 |
GeneIDi | 945903 |
KEGGi | ecj:JW1438 eco:b1443 |
PATRICi | fig|1411691.4.peg.825 |
Organism-specific databases
EchoBASEi | EB3528 |
Phylogenomic databases
eggNOGi | COG1177, Bacteria |
HOGENOMi | CLU_016047_3_0_6 |
InParanoidi | P0AFR9 |
PhylomeDBi | P0AFR9 |
Enzyme and pathway databases
BioCyci | EcoCyc:YDCV-MONOMER MetaCyc:YDCV-MONOMER |
Miscellaneous databases
PROi | PR:P0AFR9 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YDCV_ECOLI | |
Accessioni | P0AFR9Primary (citable) accession number: P0AFR9 Secondary accession number(s): P77505 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families