UniProtKB - P0AFQ2 (YBHS_ECOLI)
Protein
Probable multidrug ABC transporter permease YbhS
Gene
ybhS
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane.1 Publication
GO - Molecular functioni
- efflux transmembrane transporter activity Source: EcoCyc
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- transmembrane transport Source: GO_Central
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YBHS-MONOMER MetaCyc:YBHS-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable multidrug ABC transporter permease YbhSCurated |
Gene namesi | Name:ybhS Ordered Locus Names:b0793, JW0777 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex Source: InterPro
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | CytoplasmicCuratedAdd BLAST | 28 | |
Transmembranei | 29 – 49 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 50 – 181 | PeriplasmicCuratedAdd BLAST | 132 | |
Transmembranei | 182 – 202 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 203 – 234 | CytoplasmicCuratedAdd BLAST | 32 | |
Transmembranei | 235 – 255 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 256 – 261 | PeriplasmicCurated | 6 | |
Transmembranei | 262 – 282 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 283 – 291 | CytoplasmicCurated | 9 | |
Transmembranei | 292 – 312 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 313 – 345 | PeriplasmicCuratedAdd BLAST | 33 | |
Transmembranei | 346 – 366 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 367 – 377 | Cytoplasmic1 PublicationAdd BLAST | 11 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183005 | 1 – 377 | Probable multidrug ABC transporter permease YbhSAdd BLAST | 377 |
Proteomic databases
PaxDbi | P0AFQ2 |
PRIDEi | P0AFQ2 |
Expressioni
Inductioni
Repressed by the transcriptional regulator CecR.1 Publication
Interactioni
Subunit structurei
The complex is probably composed of two ATP-binding proteins (YbhF) and two transmembrane proteins (YbhR and YbhS).
CuratedProtein-protein interaction databases
BioGRIDi | 4261835, 12 interactors |
ComplexPortali | CPX-4443, Sodium/lithium ABC transporter complex |
IntActi | P0AFQ2, 5 interactors |
STRINGi | 511145.b0793 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 145 – 375 | ABC transmembrane type-2PROSITE-ProRule annotationAdd BLAST | 231 |
Sequence similaritiesi
Belongs to the ABC-2 integral membrane protein family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0842, Bacteria |
HOGENOMi | CLU_039483_8_3_6 |
InParanoidi | P0AFQ2 |
PhylomeDBi | P0AFQ2 |
Family and domain databases
InterProi | View protein in InterPro IPR000412, ABC_2_transport |
PROSITEi | View protein in PROSITE PS51012, ABC_TM2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AFQ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNPILSWRR VRALCVKETR QIVRDPSSWL IAVVIPLLLL FIFGYGINLD
60 70 80 90 100
SSKLRVGILL EQRSEAALDF THTMTGSPYI DATISDNRQE LIAKMQAGKI
110 120 130 140 150
RGLVVIPVDF AEQMERANAT APIQVITDGS EPNTANFVQG YVEGIWQIWQ
160 170 180 190 200
MQRAEDNGQT FEPLIDVQTR YWFNPAAISQ HFIIPGAVTI IMTVIGAILT
210 220 230 240 250
SLVVAREWER GTMEALLSTE ITRTELLLCK LIPYYFLGML AMLLCMLVSV
260 270 280 290 300
FILGVPYRGS LLILFFISSL FLLSTLGMGL LISTITRNQF NAAQVALNAA
310 320 330 340 350
FLPSIMLSGF IFQIDSMPAV IRAVTYIIPA RYFVSTLQSL FLAGNIPVVL
360 370
VVNVLFLIAS AVMFIGLTWL KTKRRLD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73880.1 AP009048 Genomic DNA Translation: BAA35453.1 |
PIRi | A64816 |
RefSeqi | NP_415314.1, NC_000913.3 WP_000070131.1, NZ_STEB01000019.1 |
Genome annotation databases
EnsemblBacteriai | AAC73880; AAC73880; b0793 BAA35453; BAA35453; BAA35453 |
GeneIDi | 58347790 945411 |
KEGGi | ecj:JW0777 eco:b0793 |
PATRICi | fig|1411691.4.peg.1485 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73880.1 AP009048 Genomic DNA Translation: BAA35453.1 |
PIRi | A64816 |
RefSeqi | NP_415314.1, NC_000913.3 WP_000070131.1, NZ_STEB01000019.1 |
3D structure databases
SMRi | P0AFQ2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261835, 12 interactors |
ComplexPortali | CPX-4443, Sodium/lithium ABC transporter complex |
IntActi | P0AFQ2, 5 interactors |
STRINGi | 511145.b0793 |
Proteomic databases
PaxDbi | P0AFQ2 |
PRIDEi | P0AFQ2 |
Protocols and materials databases
DNASUi | 945411 |
Genome annotation databases
EnsemblBacteriai | AAC73880; AAC73880; b0793 BAA35453; BAA35453; BAA35453 |
GeneIDi | 58347790 945411 |
KEGGi | ecj:JW0777 eco:b0793 |
PATRICi | fig|1411691.4.peg.1485 |
Organism-specific databases
EchoBASEi | EB3439 |
Phylogenomic databases
eggNOGi | COG0842, Bacteria |
HOGENOMi | CLU_039483_8_3_6 |
InParanoidi | P0AFQ2 |
PhylomeDBi | P0AFQ2 |
Enzyme and pathway databases
BioCyci | EcoCyc:YBHS-MONOMER MetaCyc:YBHS-MONOMER |
Miscellaneous databases
PROi | PR:P0AFQ2 |
Family and domain databases
InterProi | View protein in InterPro IPR000412, ABC_2_transport |
PROSITEi | View protein in PROSITE PS51012, ABC_TM2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YBHS_ECOLI | |
Accessioni | P0AFQ2Primary (citable) accession number: P0AFQ2 Secondary accession number(s): P75775 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families