UniProtKB - P0AFL5 (PPIA_ECO57)
Protein
Peptidyl-prolyl cis-trans isomerase A
Gene
ppiA
Organism
Escherichia coli O157:H7
Status
Functioni
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity
Catalytic activityi
- EC:5.2.1.8
GO - Molecular functioni
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW
GO - Biological processi
- protein folding Source: InterPro
Keywordsi
Molecular function | Isomerase, Rotamase |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomerase A (EC:5.2.1.8)Short name: PPIase A Alternative name(s): Cyclophilin A Rotamase A |
Gene namesi | Name:ppiA Ordered Locus Names:Z4724, ECs4214 |
Organismi | Escherichia coli O157:H7 |
Taxonomic identifieri | 83334 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Periplasm By similarity
GO - Cellular componenti
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000045120 | 25 – 190 | Peptidyl-prolyl cis-trans isomerase AAdd BLAST | 166 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 188 | PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST | 162 |
Sequence similaritiesi
Belongs to the cyclophilin-type PPIase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG0652, Bacteria |
HOGENOMi | CLU_012062_16_9_6 |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR029000, Cyclophilin-like_dom_sf IPR020892, Cyclophilin-type_PPIase_CS IPR002130, Cyclophilin-type_PPIase_dom |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SUPFAMi | SSF50891, SSF50891, 1 hit |
PROSITEi | View protein in PROSITE PS00170, CSA_PPIASE_1, 1 hit PS50072, CSA_PPIASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AFL5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFKSTLAAMA AVFALSALSP AAMAAKGDPH VLLTTSAGNI ELELDKQKAP
60 70 80 90 100
VSVQNFVDYV NSGFYNNTTF HRVIPGFMIQ GGGFTEQMQQ KKPNPPIKNE
110 120 130 140 150
ADNGLRNTRG TIAMARTADK DSATSQFFIN VADNAFLDHG QRDFGYAVFG
160 170 180 190
KVVKGMDVAD KISQVPTHDV GPYQNVPSKP VVILSAKVLP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG58471.1 BA000007 Genomic DNA Translation: BAB37637.1 |
PIRi | C86001 F91155 |
RefSeqi | NP_312241.1, NC_002695.1 WP_000477225.1, NZ_SWKA01000005.1 |
Genome annotation databases
EnsemblBacteriai | AAG58471; AAG58471; Z4724 BAB37637; BAB37637; BAB37637 |
GeneIDi | 58460188 915930 |
KEGGi | ece:Z4724 ecs:ECs4214 |
PATRICi | fig|386585.9.peg.4398 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005174 Genomic DNA Translation: AAG58471.1 BA000007 Genomic DNA Translation: BAB37637.1 |
PIRi | C86001 F91155 |
RefSeqi | NP_312241.1, NC_002695.1 WP_000477225.1, NZ_SWKA01000005.1 |
3D structure databases
BMRBi | P0AFL5 |
SMRi | P0AFL5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 155864.EDL933_4567 |
Genome annotation databases
EnsemblBacteriai | AAG58471; AAG58471; Z4724 BAB37637; BAB37637; BAB37637 |
GeneIDi | 58460188 915930 |
KEGGi | ece:Z4724 ecs:ECs4214 |
PATRICi | fig|386585.9.peg.4398 |
Phylogenomic databases
eggNOGi | COG0652, Bacteria |
HOGENOMi | CLU_012062_16_9_6 |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR029000, Cyclophilin-like_dom_sf IPR020892, Cyclophilin-type_PPIase_CS IPR002130, Cyclophilin-type_PPIase_dom |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SUPFAMi | SSF50891, SSF50891, 1 hit |
PROSITEi | View protein in PROSITE PS00170, CSA_PPIASE_1, 1 hit PS50072, CSA_PPIASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPIA_ECO57 | |
Accessioni | P0AFL5Primary (citable) accession number: P0AFL5 Secondary accession number(s): P20752 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families