potC

Functionⁱ

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine.

GO - Molecular functionⁱ

spermidine-importing ATPase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 8366082

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

putrescine transport
Source: EcoCyc
Inferred from direct assayⁱ
- 1939142
spermidine transmembrane transport
Source: EcoCyc
Inferred from direct assayⁱ
- 1939142

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:POTC-MONOMER MetaCyc:POTC-MONOMER

BioCycⁱ

EcoCyc:POTC-MONOMER
MetaCyc:POTC-MONOMER

Protein family/group databases

TCDBⁱ	3.A.1.11.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.11.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Spermidine/putrescine transport system permease protein PotC
Gene namesⁱ	Name:potC Ordered Locus Names:b1124, JW1110
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10751 potC

EcoGeneⁱ

EG10751 potC

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
; Multi-pass membrane protein
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU00441
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 7	CytoplasmicSequence analysis	7
Transmembraneⁱ	8 – 27	HelicalPROSITE-ProRule annotationAdd BLAST	20
Topological domainⁱ	28 – 65	PeriplasmicSequence analysisAdd BLAST	38
Transmembraneⁱ	66 – 85	HelicalPROSITE-ProRule annotationAdd BLAST	20
Topological domainⁱ	86 – 100	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	101 – 120	HelicalPROSITE-ProRule annotationAdd BLAST	20
Topological domainⁱ	121 – 128	PeriplasmicSequence analysis	8
Transmembraneⁱ	129 – 148	HelicalPROSITE-ProRule annotationAdd BLAST	20
Topological domainⁱ	149 – 176	CytoplasmicSequence analysisAdd BLAST	28
Transmembraneⁱ	177 – 196	HelicalPROSITE-ProRule annotationAdd BLAST	20
Topological domainⁱ	197 – 231	PeriplasmicSequence analysisAdd BLAST	35
Transmembraneⁱ	232 – 251	HelicalPROSITE-ProRule annotationAdd BLAST	20
Topological domainⁱ	252 – 264	CytoplasmicSequence analysisAdd BLAST	13

GO - Cellular componentⁱ

ATP-binding cassette (ABC) transporter complex
Source: EcoCyc
Traceable author statementⁱ
- 10585849
integral component of plasma membrane
Source: EcoCyc
Inferred from sequence modelⁱ
- 1939142
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996
- 17309111

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000060181	1 – 264	Spermidine/putrescine transport system permease protein PotCAdd BLAST		264

Proteomic databases

PaxDbⁱ	P0AFK6
PRIDEⁱ	P0AFK6

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4260092, 49 interactors
Database of interacting proteins More...DIPⁱ	DIP-48152N
IntActⁱ	P0AFK6, 1 interactor
STRINGⁱ	316385.ECDH10B_1196

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0AFK6
SMRⁱ	P0AFK6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	60 – 248	ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST		189

Sequence similaritiesⁱ

Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105D38 Bacteria COG1177 LUCA
HOGENOMⁱ	HOG000263700
InParanoidⁱ	P0AFK6
KEGG Orthology (KO) More...KOⁱ	K11070
PhylomeDBⁱ	P0AFK6

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06261 TM_PBP2, 1 hit
Gene3Dⁱ	1.10.3720.10, 1 hit
InterProⁱ	View protein in InterPro IPR000515 MetI-like IPR035906 MetI-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00528 BPD_transp_1, 1 hit
SUPFAMⁱ	SSF161098 SSF161098, 1 hit
PROSITEⁱ	View protein in PROSITE PS50928 ABC_TM1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0AFK6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIGRLLRGGF MTAIYAYLYI PIIILIVNSF NSSRFGINWQ GFTTKWYSLL 
        60         70         80         90        100
MNNDSLLQAA QHSLTMAVFS ATFATLIGSL TAVALYRYRF RGKPFVSGML 
       110        120        130        140        150
FVVMMSPDIV MAISLLVLFM LLGIQLGFWS LLFSHITFCL PFVVVTVYSR 
       160        170        180        190        200
LKGFDVRMLE AAKDLGASEF TILRKIILPL AMPAVAAGWV LSFTLSMDDV 
       210        220        230        240        250
VVSSFVTGPS YEILPLKIYS MVKVGVSPEV NALATILLVL SLVMVIASQL 
       260 
IARDKTKGNT GDVK

Length:264

Mass (Da):29,111

Last modified:December 20, 2005 - v1

Checksum:ⁱD21619C91184BB59

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M64519 Genomic DNA Translation: AAC37040.1 U00096 Genomic DNA Translation: AAC74208.1 AP009048 Genomic DNA Translation: BAA35944.1
PIRⁱ	C40840
NCBI Reference Sequences More...RefSeqⁱ	NP_415642.1, NC_000913.3 WP_000580316.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC74208; AAC74208; b1124 BAA35944; BAA35944; BAA35944
GeneIDⁱ	945691
KEGGⁱ	ecj:JW1110 eco:b1124
PATRICⁱ	fig\|1411691.4.peg.1143

Protein	Similar proteins		Species	Score	Length	Source
P0AFK6	Spermidine/putrescine transport system permease protein PotC		ECO57		264	UniRef100_P0AFK8
Spermidine/putrescine transport system permease protein PotC		ECOL6		264
Spermidine/putrescine ABC transporter permease		Shigella sp.		264
Spermidine/putrescine ABC transporter permease		Escherichia coli O145 str. RM9872		264
Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1)		Klebsiella pneumoniae IS22		264
+222

Protein	Similar proteins		Species	Score	Length	Source
P0AFK6	Spermidine/putrescine transport system permease protein PotC		ECO57		264	UniRef90_P0AFK8
Spermidine/putrescine transport system permease protein PotC		ECOL6		264
Spermidine/putrescine transport system permease protein PotC		SHIFL		264
Spermidine/putrescine ABC transporter permease		Shigella sp.		264
Spermidine/putrescine ABC transporter permease		Escherichia coli O145 str. RM9872		264
+995

Protein	Similar proteins		Species	Score	Length	Source
P0AFK6	Spermidine/putrescine transport system permease protein PotC		HAEIN		257	UniRef50_P45169
Spermidine/putrescine transport system permease protein PotC		ECO57		264
Spermidine/putrescine transport system permease protein PotC		ECOL6		264
Spermidine/putrescine transport system permease protein PotC		SHIFL		264
Spermidine/putrescine ABC transporter permease PotC		AGGAC		257
+2232

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M64519 Genomic DNA Translation: AAC37040.1 U00096 Genomic DNA Translation: AAC74208.1 AP009048 Genomic DNA Translation: BAA35944.1
PIRⁱ	C40840
RefSeqⁱ	NP_415642.1, NC_000913.3 WP_000580316.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0AFK6
SMRⁱ	P0AFK6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260092, 49 interactors
DIPⁱ	DIP-48152N
IntActⁱ	P0AFK6, 1 interactor
STRINGⁱ	316385.ECDH10B_1196

Protein family/group databases

TCDBⁱ	3.A.1.11.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.11.1 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbⁱ	P0AFK6
PRIDEⁱ	P0AFK6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC74208; AAC74208; b1124 BAA35944; BAA35944; BAA35944
GeneIDⁱ	945691
KEGGⁱ	ecj:JW1110 eco:b1124
PATRICⁱ	fig\|1411691.4.peg.1143

Organism-specific databases

EchoBASEⁱ	EB0744
EcoGeneⁱ	EG10751 potC

Phylogenomic databases

eggNOGⁱ	ENOG4105D38 Bacteria COG1177 LUCA
HOGENOMⁱ	HOG000263700
InParanoidⁱ	P0AFK6
KOⁱ	K11070
PhylomeDBⁱ	P0AFK6

Enzyme and pathway databases

BioCycⁱ	EcoCyc:POTC-MONOMER MetaCyc:POTC-MONOMER

BioCycⁱ

EcoCyc:POTC-MONOMER
MetaCyc:POTC-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0AFK6

PROⁱ

PR:P0AFK6

Family and domain databases

CDDⁱ	cd06261 TM_PBP2, 1 hit
Gene3Dⁱ	1.10.3720.10, 1 hit
InterProⁱ	View protein in InterPro IPR000515 MetI-like IPR035906 MetI-like_sf
Pfamⁱ	View protein in Pfam PF00528 BPD_transp_1, 1 hit
SUPFAMⁱ	SSF161098 SSF161098, 1 hit
PROSITEⁱ	View protein in PROSITE PS50928 ABC_TM1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	POTC_ECOLI
Accessionⁱ	P0AFK6Primary (citable) accession number: P0AFK6 Secondary accession number(s): P23859
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	December 20, 2005
	Last modified:	November 7, 2018
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0AFK6 (POTC_ECOLI)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Spermidine/putrescine transport system permease protein PotC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ