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Protein

Spermidine/putrescine transport system permease protein PotC

Gene

potC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine.

GO - Molecular functioni

  • spermidine-importing ATPase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:POTC-MONOMER
MetaCyc:POTC-MONOMER

Protein family/group databases

TCDBi3.A.1.11.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine/putrescine transport system permease protein PotC
Gene namesi
Name:potC
Ordered Locus Names:b1124, JW1110
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10751 potC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 27HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini28 – 65PeriplasmicSequence analysisAdd BLAST38
Transmembranei66 – 85HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini86 – 100CytoplasmicSequence analysisAdd BLAST15
Transmembranei101 – 120HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini121 – 128PeriplasmicSequence analysis8
Transmembranei129 – 148HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini149 – 176CytoplasmicSequence analysisAdd BLAST28
Transmembranei177 – 196HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini197 – 231PeriplasmicSequence analysisAdd BLAST35
Transmembranei232 – 251HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini252 – 264CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000601811 – 264Spermidine/putrescine transport system permease protein PotCAdd BLAST264

Proteomic databases

PaxDbiP0AFK6
PRIDEiP0AFK6

Interactioni

Protein-protein interaction databases

BioGridi4260092, 49 interactors
DIPiDIP-48152N
IntActiP0AFK6, 1 interactor
STRINGi316385.ECDH10B_1196

Structurei

3D structure databases

ProteinModelPortaliP0AFK6
SMRiP0AFK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 248ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST189

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D38 Bacteria
COG1177 LUCA
HOGENOMiHOG000263700
InParanoidiP0AFK6
KOiK11070
PhylomeDBiP0AFK6

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR000515 MetI-like
IPR035906 MetI-like_sf
PfamiView protein in Pfam
PF00528 BPD_transp_1, 1 hit
SUPFAMiSSF161098 SSF161098, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 1 hit

Sequencei

Sequence statusi: Complete.

P0AFK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGRLLRGGF MTAIYAYLYI PIIILIVNSF NSSRFGINWQ GFTTKWYSLL
60 70 80 90 100
MNNDSLLQAA QHSLTMAVFS ATFATLIGSL TAVALYRYRF RGKPFVSGML
110 120 130 140 150
FVVMMSPDIV MAISLLVLFM LLGIQLGFWS LLFSHITFCL PFVVVTVYSR
160 170 180 190 200
LKGFDVRMLE AAKDLGASEF TILRKIILPL AMPAVAAGWV LSFTLSMDDV
210 220 230 240 250
VVSSFVTGPS YEILPLKIYS MVKVGVSPEV NALATILLVL SLVMVIASQL
260
IARDKTKGNT GDVK
Length:264
Mass (Da):29,111
Last modified:December 20, 2005 - v1
Checksum:iD21619C91184BB59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64519 Genomic DNA Translation: AAC37040.1
U00096 Genomic DNA Translation: AAC74208.1
AP009048 Genomic DNA Translation: BAA35944.1
PIRiC40840
RefSeqiNP_415642.1, NC_000913.3
WP_000580316.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74208; AAC74208; b1124
BAA35944; BAA35944; BAA35944
GeneIDi945691
KEGGiecj:JW1110
eco:b1124
PATRICifig|1411691.4.peg.1143

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64519 Genomic DNA Translation: AAC37040.1
U00096 Genomic DNA Translation: AAC74208.1
AP009048 Genomic DNA Translation: BAA35944.1
PIRiC40840
RefSeqiNP_415642.1, NC_000913.3
WP_000580316.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AFK6
SMRiP0AFK6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260092, 49 interactors
DIPiDIP-48152N
IntActiP0AFK6, 1 interactor
STRINGi316385.ECDH10B_1196

Protein family/group databases

TCDBi3.A.1.11.1 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP0AFK6
PRIDEiP0AFK6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74208; AAC74208; b1124
BAA35944; BAA35944; BAA35944
GeneIDi945691
KEGGiecj:JW1110
eco:b1124
PATRICifig|1411691.4.peg.1143

Organism-specific databases

EchoBASEiEB0744
EcoGeneiEG10751 potC

Phylogenomic databases

eggNOGiENOG4105D38 Bacteria
COG1177 LUCA
HOGENOMiHOG000263700
InParanoidiP0AFK6
KOiK11070
PhylomeDBiP0AFK6

Enzyme and pathway databases

BioCyciEcoCyc:POTC-MONOMER
MetaCyc:POTC-MONOMER

Miscellaneous databases

PROiPR:P0AFK6

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR000515 MetI-like
IPR035906 MetI-like_sf
PfamiView protein in Pfam
PF00528 BPD_transp_1, 1 hit
SUPFAMiSSF161098 SSF161098, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOTC_ECOLI
AccessioniPrimary (citable) accession number: P0AFK6
Secondary accession number(s): P23859
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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