UniProtKB - P0AFK6 (POTC_ECOLI)
Protein
Spermidine/putrescine transport system permease protein PotC
Gene
potC
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine.
GO - Molecular functioni
- ABC-type polyamine transporter activity Source: EcoCyc
GO - Biological processi
- putrescine transport Source: EcoCyc
- spermidine transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:POTC-MONOMER MetaCyc:POTC-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.11.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Spermidine/putrescine transport system permease protein PotC |
Gene namesi | Name:potC Ordered Locus Names:b1124, JW1110 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein PROSITE-ProRule annotation1 Publication
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex Source: EcoCyc
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 8 – 27 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 28 – 65 | PeriplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 66 – 85 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 86 – 100 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 101 – 120 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 121 – 128 | PeriplasmicSequence analysis | 8 | |
Transmembranei | 129 – 148 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 149 – 176 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 177 – 196 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 197 – 231 | PeriplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 232 – 251 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 252 – 264 | CytoplasmicSequence analysisAdd BLAST | 13 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060181 | 1 – 264 | Spermidine/putrescine transport system permease protein PotCAdd BLAST | 264 |
Proteomic databases
jPOSTi | P0AFK6 |
PaxDbi | P0AFK6 |
PRIDEi | P0AFK6 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260092, 49 interactors |
ComplexPortali | CPX-4383, Spermidine ABC transporter complex |
DIPi | DIP-48152N |
IntActi | P0AFK6, 1 interactor |
STRINGi | 511145.b1124 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 248 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 189 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1177, Bacteria |
HOGENOMi | CLU_016047_3_0_6 |
InParanoidi | P0AFK6 |
PhylomeDBi | P0AFK6 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AFK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIGRLLRGGF MTAIYAYLYI PIIILIVNSF NSSRFGINWQ GFTTKWYSLL
60 70 80 90 100
MNNDSLLQAA QHSLTMAVFS ATFATLIGSL TAVALYRYRF RGKPFVSGML
110 120 130 140 150
FVVMMSPDIV MAISLLVLFM LLGIQLGFWS LLFSHITFCL PFVVVTVYSR
160 170 180 190 200
LKGFDVRMLE AAKDLGASEF TILRKIILPL AMPAVAAGWV LSFTLSMDDV
210 220 230 240 250
VVSSFVTGPS YEILPLKIYS MVKVGVSPEV NALATILLVL SLVMVIASQL
260
IARDKTKGNT GDVK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64519 Genomic DNA Translation: AAC37040.1 U00096 Genomic DNA Translation: AAC74208.1 AP009048 Genomic DNA Translation: BAA35944.1 |
PIRi | C40840 |
RefSeqi | NP_415642.1, NC_000913.3 WP_000580316.1, NZ_SSUV01000046.1 |
Genome annotation databases
EnsemblBacteriai | AAC74208; AAC74208; b1124 BAA35944; BAA35944; BAA35944 |
GeneIDi | 58461242 945691 |
KEGGi | ecj:JW1110 eco:b1124 |
PATRICi | fig|1411691.4.peg.1143 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64519 Genomic DNA Translation: AAC37040.1 U00096 Genomic DNA Translation: AAC74208.1 AP009048 Genomic DNA Translation: BAA35944.1 |
PIRi | C40840 |
RefSeqi | NP_415642.1, NC_000913.3 WP_000580316.1, NZ_SSUV01000046.1 |
3D structure databases
SMRi | P0AFK6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260092, 49 interactors |
ComplexPortali | CPX-4383, Spermidine ABC transporter complex |
DIPi | DIP-48152N |
IntActi | P0AFK6, 1 interactor |
STRINGi | 511145.b1124 |
Protein family/group databases
TCDBi | 3.A.1.11.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P0AFK6 |
PaxDbi | P0AFK6 |
PRIDEi | P0AFK6 |
Genome annotation databases
EnsemblBacteriai | AAC74208; AAC74208; b1124 BAA35944; BAA35944; BAA35944 |
GeneIDi | 58461242 945691 |
KEGGi | ecj:JW1110 eco:b1124 |
PATRICi | fig|1411691.4.peg.1143 |
Organism-specific databases
EchoBASEi | EB0744 |
Phylogenomic databases
eggNOGi | COG1177, Bacteria |
HOGENOMi | CLU_016047_3_0_6 |
InParanoidi | P0AFK6 |
PhylomeDBi | P0AFK6 |
Enzyme and pathway databases
BioCyci | EcoCyc:POTC-MONOMER MetaCyc:POTC-MONOMER |
Miscellaneous databases
PROi | PR:P0AFK6 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | POTC_ECOLI | |
Accessioni | P0AFK6Primary (citable) accession number: P0AFK6 Secondary accession number(s): P23859 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | April 7, 2021 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families