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Protein

Transcription termination/antitermination protein NusG

Gene

nusG

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination.UniRule annotation

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription antitermination, Transcription regulation, Transcription termination

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination/antitermination protein NusGUniRule annotation
Gene namesi
Name:nusGUniRule annotation
Ordered Locus Names:Z5555, ECs4905
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001139272 – 181Transcription termination/antitermination protein NusGAdd BLAST180

Proteomic databases

PRIDEiP0AFG1

Interactioni

Subunit structurei

Monomer. Interacts with the transcription termination factor Rho and with RNA polymerase.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z5555

Structurei

3D structure databases

ProteinModelPortaliP0AFG1
SMRiP0AFG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 161KOWUniRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the NusG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E5V Bacteria
COG0250 LUCA
HOGENOMiHOG000219264
KOiK02601
OMAiDGPFNGF

Family and domain databases

Gene3Di2.30.30.30, 1 hit
3.30.70.940, 1 hit
HAMAPiMF_00948 NusG, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR006645 NGN_dom
IPR036735 NGN_dom_sf
IPR014722 Rib_L2_dom2
IPR001062 Transcrpt_antiterm_NusG
IPR015869 Transcrpt_antiterm_NusG_bac_CS
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR30265:SF2 PTHR30265:SF2, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF02357 NusG, 1 hit
PRINTSiPR00338 NUSGTNSCPFCT
SMARTiView protein in SMART
SM00739 KOW, 1 hit
SM00738 NGN, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF82679 SSF82679, 1 hit
TIGRFAMsiTIGR00922 nusG, 1 hit
PROSITEiView protein in PROSITE
PS01014 NUSG, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AFG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAPKKRWY VVQAFSGFEG RVATSLREHI KLHNMEDLFG EVMVPTEEVV
60 70 80 90 100
EIRGGQRRKS ERKFFPGYVL VQMVMNDASW HLVRSVPRVM GFIGGTSDRP
110 120 130 140 150
APISDKEVDA IMNRLQQVGD KPRPKTLFEP GEMVRVNDGP FADFNGVVEE
160 170 180
VDYEKSRLKV SVSIFGRATP VELDFSQVEK A
Length:181
Mass (Da):20,532
Last modified:January 23, 2007 - v2
Checksum:iB3AF94284CC17B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59178.1
BA000007 Genomic DNA Translation: BAB38328.1
PIRiA98242
F86089
RefSeqiNP_312932.1, NC_002695.1
WP_001287516.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG59178; AAG59178; Z5555
BAB38328; BAB38328; BAB38328
GeneIDi914947
KEGGiece:Z5555
ecs:ECs4905
PATRICifig|386585.9.peg.5129

Similar proteinsi

Entry informationi

Entry nameiNUSG_ECO57
AccessioniPrimary (citable) accession number: P0AFG1
Secondary accession number(s): P16921
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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