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Protein

Nucleoside permease NupC

Gene

nupC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force. Transports cytidine, uridine, thymidine, adenosine and inosine. Can also transport xanthosine, but with a very low affinity.3 Publications

Miscellaneous

Binding of nucleosides to NupC requires the presence of hydroxyl groups at the C-3' position of ribose.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytidine transmembrane transporter activity Source: EcoliWiki
  • nucleoside:proton symporter activity Source: EcoCyc
  • nucleoside transmembrane transporter activity Source: GO_Central
  • uridine transmembrane transporter activity Source: EcoliWiki

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:NUPC-MONOMER
MetaCyc:NUPC-MONOMER

Protein family/group databases

Transport Classification Database

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TCDBi
2.A.41.1.1 the concentrative nucleoside transporter (cnt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoside permease NupCCurated
Alternative name(s):
Nucleoside-transport system protein NupCCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nupC1 Publication
Synonyms:cru
Ordered Locus Names:b2393, JW2389
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG11971 nupC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 3CytoplasmicCurated3
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 36PeriplasmicCuratedAdd BLAST12
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 86CytoplasmicCuratedAdd BLAST29
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 168PeriplasmicCuratedAdd BLAST61
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 192CytoplasmicCurated3
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 250PeriplasmicCuratedAdd BLAST37
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 281CytoplasmicCurated10
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 341PeriplasmicCuratedAdd BLAST39
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 378CytoplasmicCuratedAdd BLAST16
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400Periplasmic1 Publication1

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000704541 – 400Nucleoside permease NupCAdd BLAST400

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P0AFF2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AFF2

PRoteomics IDEntifications database

More...
PRIDEi
P0AFF2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
4259184, 18 interactors

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_2557

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P0AFF2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0AFF2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4105D9N Bacteria
COG1972 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000267657

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AFF2

KEGG Orthology (KO)

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KOi
K11535

Database for complete collections of gene phylogenies

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PhylomeDBi
P0AFF2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10590 PTHR10590, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00804 nupC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AFF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRVLHFVLA LAVVAILALL VSSDRKKIRI RYVIQLLVIE VLLAWFFLNS
60 70 80 90 100
DVGLGFVKGF SEMFEKLLGF ANEGTNFVFG SMNDQGLAFF FLKVLCPIVF
110 120 130 140 150
ISALIGILQH IRVLPVIIRA IGFLLSKVNG MGKLESFNAV SSLILGQSEN
160 170 180 190 200
FIAYKDILGK ISRNRMYTMA ATAMSTVSMS IVGAYMTMLE PKYVVAALVL
210 220 230 240 250
NMFSTFIVLS LINPYRVDAS EENIQMSNLH EGQSFFEMLG EYILAGFKVA
260 270 280 290 300
IIVAAMLIGF IALIAALNAL FATVTGWFGY SISFQGILGY IFYPIAWVMG
310 320 330 340 350
VPSSEALQVG SIMATKLVSN EFVAMMDLQK IASTLSPRAE GIISVFLVSF
360 370 380 390 400
ANFSSIGIIA GAVKGLNEEQ GNVVSRFGLK LVYGSTLVSV LSASIAALVL
Length:400
Mass (Da):43,476
Last modified:December 20, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EA1DE138C4351CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82Missing in CAA52821 (PubMed:8022285).Curated1
Sequence conflicti88A → AE in CAA52821 (PubMed:8022285).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X74825 Genomic DNA Translation: CAA52821.1
U00096 Genomic DNA Translation: AAC75452.1
AP009048 Genomic DNA Translation: BAA16263.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F65013

NCBI Reference Sequences

More...
RefSeqi
NP_416894.1, NC_000913.3
WP_000376337.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75452; AAC75452; b2393
BAA16263; BAA16263; BAA16263

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946895

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2389
eco:b2393

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.4336

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74825 Genomic DNA Translation: CAA52821.1
U00096 Genomic DNA Translation: AAC75452.1
AP009048 Genomic DNA Translation: BAA16263.1
PIRiF65013
RefSeqiNP_416894.1, NC_000913.3
WP_000376337.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AFF2
SMRiP0AFF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259184, 18 interactors
STRINGi316385.ECDH10B_2557

Protein family/group databases

TCDBi2.A.41.1.1 the concentrative nucleoside transporter (cnt) family

Proteomic databases

jPOSTiP0AFF2
PaxDbiP0AFF2
PRIDEiP0AFF2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75452; AAC75452; b2393
BAA16263; BAA16263; BAA16263
GeneIDi946895
KEGGiecj:JW2389
eco:b2393
PATRICifig|1411691.4.peg.4336

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1914
EcoGeneiEG11971 nupC

Phylogenomic databases

eggNOGiENOG4105D9N Bacteria
COG1972 LUCA
HOGENOMiHOG000267657
InParanoidiP0AFF2
KOiK11535
PhylomeDBiP0AFF2

Enzyme and pathway databases

BioCyciEcoCyc:NUPC-MONOMER
MetaCyc:NUPC-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AFF2

Family and domain databases

InterProiView protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom
PANTHERiPTHR10590 PTHR10590, 1 hit
PfamiView protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804 nupC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUPC_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AFF2
Secondary accession number(s): P33031, P77236
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 16, 2019
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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