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UniProtKB - P0AF63 (NSRR_ECOLI)
Protein
HTH-type transcriptional repressor NsrR
Gene
nsrR
Organism
Escherichia coli (strain K12)
Status
Functioni
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress, such as ytfE, hmpA and ygbA. May require iron for activity. Does not regulates its own transcription.
1 PublicationCofactori
[2Fe-2S] clusterCuratedNote: Binds 1 [2Fe-2S] cluster per subunit.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 91 | Iron-sulfur (2Fe-2S)Sequence analysis | 1 | |
Metal bindingi | 96 | Iron-sulfur (2Fe-2S)Sequence analysis | 1 | |
Metal bindingi | 102 | Iron-sulfur (2Fe-2S)Sequence analysis | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 28 – 51 | H-T-H motifBy similarityAdd BLAST | 24 |
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: GO_Central
- double-stranded DNA binding Source: UniProtKB-UniRule
- iron ion binding Source: UniProtKB-UniRule
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: InterPro
- regulation of transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | 2Fe-2S, Iron, Iron-sulfur, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11212-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional repressor NsrR |
Gene namesi | Name:nsrR Synonyms:yjeB Ordered Locus Names:b4178, JW4136 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000109555 | 1 – 141 | HTH-type transcriptional repressor NsrRAdd BLAST | 141 |
Proteomic databases
jPOSTi | P0AF63 |
PaxDbi | P0AF63 |
PRIDEi | P0AF63 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262026, 16 interactors |
DIPi | DIP-48211N |
IntActi | P0AF63, 1 interactor |
STRINGi | 511145.b4178 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 129 | HTH rrf2-typeAdd BLAST | 128 |
Phylogenomic databases
eggNOGi | COG1959, Bacteria |
HOGENOMi | CLU_107144_2_1_6 |
InParanoidi | P0AF63 |
PhylomeDBi | P0AF63 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_01177, HTH_type_NsrR, 1 hit |
InterProi | View protein in InterPro IPR030489, TR_Rrf2-type_CS IPR000944, Tscrpt_reg_Rrf2 IPR023761, Tscrpt_rep_HTH_NsrR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR33221, PTHR33221, 1 hit |
Pfami | View protein in Pfam PF02082, Rrf2, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR00738, rrf2_super, 1 hit |
PROSITEi | View protein in PROSITE PS01332, HTH_RRF2_1, 1 hit PS51197, HTH_RRF2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AF63-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQLTSFTDYG LRALIYMASL PEGRMTSISE VTDVYGVSRN HMVKIINQLS
60 70 80 90 100
RAGYVTAVRG KNGGIRLGKP ASAIRIGDVV RELEPLSLVN CSSEFCHITP
110 120 130 140
ACRLKQALSK AVQSFLTELD NYTLADLVEE NQPLYKLLLV E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04199 Genomic DNA No translation available. U14003 Genomic DNA Translation: AAA97074.1 U00096 Genomic DNA Translation: AAC77135.1 AP009048 Genomic DNA Translation: BAE78179.1 |
PIRi | S56403 |
RefSeqi | NP_418599.1, NC_000913.3 WP_001177639.1, NZ_SSZK01000052.1 |
Genome annotation databases
EnsemblBacteriai | AAC77135; AAC77135; b4178 BAE78179; BAE78179; BAE78179 |
GeneIDi | 67414796 948693 |
KEGGi | ecj:JW4136 eco:b4178 |
PATRICi | fig|1411691.4.peg.2523 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04199 Genomic DNA No translation available. U14003 Genomic DNA Translation: AAA97074.1 U00096 Genomic DNA Translation: AAC77135.1 AP009048 Genomic DNA Translation: BAE78179.1 |
PIRi | S56403 |
RefSeqi | NP_418599.1, NC_000913.3 WP_001177639.1, NZ_SSZK01000052.1 |
3D structure databases
SMRi | P0AF63 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262026, 16 interactors |
DIPi | DIP-48211N |
IntActi | P0AF63, 1 interactor |
STRINGi | 511145.b4178 |
Proteomic databases
jPOSTi | P0AF63 |
PaxDbi | P0AF63 |
PRIDEi | P0AF63 |
Protocols and materials databases
DNASUi | 948693 |
Genome annotation databases
EnsemblBacteriai | AAC77135; AAC77135; b4178 BAE78179; BAE78179; BAE78179 |
GeneIDi | 67414796 948693 |
KEGGi | ecj:JW4136 eco:b4178 |
PATRICi | fig|1411691.4.peg.2523 |
Organism-specific databases
EchoBASEi | EB1197 |
Phylogenomic databases
eggNOGi | COG1959, Bacteria |
HOGENOMi | CLU_107144_2_1_6 |
InParanoidi | P0AF63 |
PhylomeDBi | P0AF63 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11212-MONOMER |
Miscellaneous databases
PROi | PR:P0AF63 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_01177, HTH_type_NsrR, 1 hit |
InterProi | View protein in InterPro IPR030489, TR_Rrf2-type_CS IPR000944, Tscrpt_reg_Rrf2 IPR023761, Tscrpt_rep_HTH_NsrR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR33221, PTHR33221, 1 hit |
Pfami | View protein in Pfam PF02082, Rrf2, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR00738, rrf2_super, 1 hit |
PROSITEi | View protein in PROSITE PS01332, HTH_RRF2_1, 1 hit PS51197, HTH_RRF2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NSRR_ECOLI | |
Accessioni | P0AF63Primary (citable) accession number: P0AF63 Secondary accession number(s): P21498, P72442, Q2M6C7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 23, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |