UniProtKB - P0AF10 (MTLR_ECOLI)
Protein
Mannitol operon repressor
Gene
mtlR
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in the repression of the expression of the mannitol mtlADR operon (PubMed:8300537). Does not bind the operator/promoter regulatory region of this operon (PubMed:19840941). Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex.2 Publications
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:PD00369 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannitol operon repressor1 PublicationAlternative name(s): Mannitol repressor protein1 Publication |
Gene namesi | Name:mtlR1 Publication Ordered Locus Names:b3601, JW3575 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Inactivation of this gene leads to the constitutive expression of the mannitol operon.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096628 | 1 – 195 | Mannitol operon repressorAdd BLAST | 195 |
Proteomic databases
PaxDbi | P0AF10 |
PRIDEi | P0AF10 |
Interactioni
Subunit structurei
Homodimer. Can also form higher level multimer aggregates.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4263545, 10 interactors 852423, 3 interactors |
IntActi | P0AF10, 11 interactors |
STRINGi | 511145.b3601 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0AF10 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the MtlR/FumE family.Curated
Phylogenomic databases
eggNOGi | COG3722, Bacteria |
HOGENOMi | CLU_099448_0_0_6 |
Family and domain databases
InterProi | View protein in InterPro IPR007761, MtlR-like IPR038026, MtlR-like_sf |
PANTHERi | PTHR37941, PTHR37941, 1 hit |
Pfami | View protein in Pfam PF05068, MtlR, 1 hit |
SUPFAMi | SSF158668, SSF158668, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AF10-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDQAQDTLR PNNRLSDMQA TMEQTQAFEN RVLERLNAGK TVRSFLITAV
60 70 80 90 100
ELLTEAVNLL VLQVFRKDDY AVKYAVEPLL DGDGPLGDLS VRLKLIYGLG
110 120 130 140 150
VINRQEYEDA ELLMALREEL NHDGNEYAFT DDEILGPFGE LHCVAALPPP
160 170 180 190
PQFEPADSSL YAMQIQRYQQ AVRSTMVLSL TELISKISLK KAFQK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03845 Genomic DNA Translation: AAA92662.1 X51359 Genomic DNA No translation available. U00039 Genomic DNA Translation: AAB18578.1 U00096 Genomic DNA Translation: AAC76625.1 AP009048 Genomic DNA Translation: BAE77692.1 |
PIRi | B36970 |
RefSeqi | NP_418058.1, NC_000913.3 WP_000228269.1, NZ_SSZK01000022.1 |
Genome annotation databases
EnsemblBacteriai | AAC76625; AAC76625; b3601 BAE77692; BAE77692; BAE77692 |
GeneIDi | 49582428 948116 |
KEGGi | ecj:JW3575 eco:b3601 |
PATRICi | fig|1411691.4.peg.3106 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03845 Genomic DNA Translation: AAA92662.1 X51359 Genomic DNA No translation available. U00039 Genomic DNA Translation: AAB18578.1 U00096 Genomic DNA Translation: AAC76625.1 AP009048 Genomic DNA Translation: BAE77692.1 |
PIRi | B36970 |
RefSeqi | NP_418058.1, NC_000913.3 WP_000228269.1, NZ_SSZK01000022.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6KCR | X-ray | 3.50 | A/C | 1-195 | [»] | |
SMRi | P0AF10 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4263545, 10 interactors 852423, 3 interactors |
IntActi | P0AF10, 11 interactors |
STRINGi | 511145.b3601 |
Proteomic databases
PaxDbi | P0AF10 |
PRIDEi | P0AF10 |
Genome annotation databases
EnsemblBacteriai | AAC76625; AAC76625; b3601 BAE77692; BAE77692; BAE77692 |
GeneIDi | 49582428 948116 |
KEGGi | ecj:JW3575 eco:b3601 |
PATRICi | fig|1411691.4.peg.3106 |
Organism-specific databases
EchoBASEi | EB1908 |
Phylogenomic databases
eggNOGi | COG3722, Bacteria |
HOGENOMi | CLU_099448_0_0_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:PD00369 |
Miscellaneous databases
PROi | PR:P0AF10 |
Family and domain databases
InterProi | View protein in InterPro IPR007761, MtlR-like IPR038026, MtlR-like_sf |
PANTHERi | PTHR37941, PTHR37941, 1 hit |
Pfami | View protein in Pfam PF05068, MtlR, 1 hit |
SUPFAMi | SSF158668, SSF158668, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTLR_ECOLI | |
Accessioni | P0AF10Primary (citable) accession number: P0AF10 Secondary accession number(s): P36563, Q2M7R4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families