UniProtKB - P0AF08 (APBC_ECOLI)
Protein
Iron-sulfur cluster carrier protein
Gene
mrp
Organism
Escherichia coli (strain K12)
Status
Functioni
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 115 – 122 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: GO_Central
- ATPase activity Source: UniProtKB-UniRule
- ATP binding Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- iron-sulfur cluster assembly Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10611-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Iron-sulfur cluster carrier proteinUniRule annotation |
Gene namesi | Name:mrp Ordered Locus Names:b2113, JW2100 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184932 | 1 – 369 | Iron-sulfur cluster carrier proteinAdd BLAST | 369 |
Proteomic databases
jPOSTi | P0AF08 |
PaxDbi | P0AF08 |
PRIDEi | P0AF08 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
BioGRIDi | 4259514, 62 interactors |
IntActi | P0AF08, 6 interactors |
STRINGi | 511145.b2113 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Mrp/NBP35 ATP-binding proteins family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0489, Bacteria |
HOGENOMi | CLU_024839_0_0_6 |
InParanoidi | P0AF08 |
PhylomeDBi | P0AF08 |
Family and domain databases
HAMAPi | MF_02040, Mrp_NBP35, 1 hit |
InterProi | View protein in InterPro IPR034904, FSCA_dom_sf IPR019591, Mrp/NBP35_ATP-bd IPR000808, Mrp_CS IPR027417, P-loop_NTPase IPR033756, YlxH/NBP35 |
Pfami | View protein in Pfam PF10609, ParA, 1 hit |
SUPFAMi | SSF117916, SSF117916, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS01215, MRP, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AF08-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNEQSQAKSP EALRAMVAGT LANFQHPTLK HNLTTLKALH HVAWMDDTLH
60 70 80 90 100
VELVMPFVWH SAFEELKEQC SAELLRITGA KAIDWKLSHN IATLKRVKNQ
110 120 130 140 150
PGINGVKNII AVSSGKGGVG KSSTAVNLAL ALAAEGAKVG ILDADIYGPS
160 170 180 190 200
IPTMLGAENQ RPTSPDGTHM APIMSHGLAT NSIGYLVTDD NAMVWRGPMA
210 220 230 240 250
SKALMQMLQE TLWPDLDYLV LDMPPGTGDI QLTLAQNIPV TGAVVVTTPQ
260 270 280 290 300
DIALIDAKKG IVMFEKVEVP VLGIVENMSV HICSNCGHHE PIFGTGGAEK
310 320 330 340 350
LAEKYHTQLL GQMPLHISLR EDLDKGTPTV ISRPESEFTA IYRQLADRVA
360
AQLYWQGEVI PGEISFRAV
Sequence cautioni
The sequence AAA60527 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00007 Genomic DNA Translation: AAA60527.1 Different initiation. X55791 Genomic DNA Translation: CAA39316.1 U00096 Genomic DNA Translation: AAC75174.2 AP009048 Genomic DNA Translation: BAE76591.1 |
RefSeqi | NP_416616.4, NC_000913.3 WP_001005448.1, NZ_STEB01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC75174; AAC75174; b2113 BAE76591; BAE76591; BAE76591 |
GeneIDi | 49584066 946627 |
KEGGi | ecj:JW2100 eco:b2113 |
PATRICi | fig|1411691.4.peg.134 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00007 Genomic DNA Translation: AAA60527.1 Different initiation. X55791 Genomic DNA Translation: CAA39316.1 U00096 Genomic DNA Translation: AAC75174.2 AP009048 Genomic DNA Translation: BAE76591.1 |
RefSeqi | NP_416616.4, NC_000913.3 WP_001005448.1, NZ_STEB01000002.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259514, 62 interactors |
IntActi | P0AF08, 6 interactors |
STRINGi | 511145.b2113 |
Proteomic databases
jPOSTi | P0AF08 |
PaxDbi | P0AF08 |
PRIDEi | P0AF08 |
Genome annotation databases
EnsemblBacteriai | AAC75174; AAC75174; b2113 BAE76591; BAE76591; BAE76591 |
GeneIDi | 49584066 946627 |
KEGGi | ecj:JW2100 eco:b2113 |
PATRICi | fig|1411691.4.peg.134 |
Organism-specific databases
EchoBASEi | EB0606 |
Phylogenomic databases
eggNOGi | COG0489, Bacteria |
HOGENOMi | CLU_024839_0_0_6 |
InParanoidi | P0AF08 |
PhylomeDBi | P0AF08 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10611-MONOMER |
Miscellaneous databases
PROi | PR:P0AF08 |
Family and domain databases
HAMAPi | MF_02040, Mrp_NBP35, 1 hit |
InterProi | View protein in InterPro IPR034904, FSCA_dom_sf IPR019591, Mrp/NBP35_ATP-bd IPR000808, Mrp_CS IPR027417, P-loop_NTPase IPR033756, YlxH/NBP35 |
Pfami | View protein in Pfam PF10609, ParA, 1 hit |
SUPFAMi | SSF117916, SSF117916, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS01215, MRP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | APBC_ECOLI | |
Accessioni | P0AF08Primary (citable) accession number: P0AF08 Secondary accession number(s): P21590, Q2MAW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families