UniProtKB - P0AEZ9 (MOAB_ECOLI)
Protein
Molybdenum cofactor biosynthesis protein B
Gene
moaB
Organism
Escherichia coli (strain K12)
Status
Functioni
May be involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity.
: molybdopterin biosynthesis Pathwayi
This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 110 | GTPCurated | 1 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
- identical protein binding Source: EcoCyc
GO - Biological processi
- Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-KW
- protein hexamerization Source: EcoCyc
Keywordsi
Biological process | Molybdenum cofactor biosynthesis |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:MONOMER0-1501 |
UniPathwayi | UPA00344 |
Names & Taxonomyi
Protein namesi | Recommended name: Molybdenum cofactor biosynthesis protein B |
Gene namesi | Name:moaB Synonyms:chlA2 Ordered Locus Names:b0782, JW0765 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000170970 | 2 – 170 | Molybdenum cofactor biosynthesis protein BAdd BLAST | 169 |
Proteomic databases
jPOSTi | P0AEZ9 |
PaxDbi | P0AEZ9 |
PRIDEi | P0AEZ9 |
2D gel databases
SWISS-2DPAGEi | P0AEZ9 |
Expressioni
Inductioni
By anaerobiosis, repressed by the molybdenum cofactor.
Interactioni
Subunit structurei
Homohexamer. Dimer of trimers.
1 PublicationGO - Molecular functioni
- identical protein binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4259950, 23 interactors |
IntActi | P0AEZ9, 4 interactors |
STRINGi | 511145.b0782 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0AEZ9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0AEZ9 |
Family & Domainsi
Sequence similaritiesi
Belongs to the MoaB/Mog family.Curated
Phylogenomic databases
eggNOGi | COG0521, Bacteria |
HOGENOMi | CLU_077358_2_2_6 |
InParanoidi | P0AEZ9 |
PhylomeDBi | P0AEZ9 |
Family and domain databases
CDDi | cd00886, MogA_MoaB, 1 hit |
Gene3Di | 3.40.980.10, 1 hit |
InterProi | View protein in InterPro IPR012245, MoaB IPR036425, MoaB/Mog-like_dom_sf IPR001453, MoaB/Mog_dom IPR013484, MoaB_proteobac IPR008284, MoCF_biosynth_CS |
PANTHERi | PTHR43232, PTHR43232, 1 hit |
Pfami | View protein in Pfam PF00994, MoCF_biosynth, 1 hit |
PIRSFi | PIRSF006443, MoaB, 1 hit |
SMARTi | View protein in SMART SM00852, MoCF_biosynth, 1 hit |
SUPFAMi | SSF53218, SSF53218, 1 hit |
TIGRFAMsi | TIGR02667, moaB_proteo, 1 hit TIGR00177, molyb_syn, 1 hit |
PROSITEi | View protein in PROSITE PS01078, MOCF_BIOSYNTHESIS_1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0AEZ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQVSTEFIP TRIAILTVSN RRGEEDDTSG HYLRDSAQEA GHHVVDKAIV
60 70 80 90 100
KENRYAIRAQ VSAWIASDDV QVVLITGGTG LTEGDQAPEA LLPLFDREVE
110 120 130 140 150
GFGEVFRMLS FEEIGTSTLQ SRAVAGVANK TLIFAMPGST KACRTAWENI
160 170
IAPQLDARTR PCNFHPHLKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70420 Genomic DNA Translation: CAA49862.1 U00096 Genomic DNA Translation: AAC73869.1 AP009048 Genomic DNA Translation: BAA35440.1 |
PIRi | S34999, S31880 |
RefSeqi | NP_415303.1, NC_000913.3 WP_000084639.1, NZ_SSZK01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC73869; AAC73869; b0782 BAA35440; BAA35440; BAA35440 |
GeneIDi | 49585469 945396 |
KEGGi | ecj:JW0765 eco:b0782 |
PATRICi | fig|1411691.4.peg.1496 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70420 Genomic DNA Translation: CAA49862.1 U00096 Genomic DNA Translation: AAC73869.1 AP009048 Genomic DNA Translation: BAA35440.1 |
PIRi | S34999, S31880 |
RefSeqi | NP_415303.1, NC_000913.3 WP_000084639.1, NZ_SSZK01000002.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MKZ | X-ray | 1.60 | A/B | 1-170 | [»] | |
1R2K | X-ray | 2.10 | A/B | 2-170 | [»] | |
SMRi | P0AEZ9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4259950, 23 interactors |
IntActi | P0AEZ9, 4 interactors |
STRINGi | 511145.b0782 |
2D gel databases
SWISS-2DPAGEi | P0AEZ9 |
Proteomic databases
jPOSTi | P0AEZ9 |
PaxDbi | P0AEZ9 |
PRIDEi | P0AEZ9 |
Genome annotation databases
EnsemblBacteriai | AAC73869; AAC73869; b0782 BAA35440; BAA35440; BAA35440 |
GeneIDi | 49585469 945396 |
KEGGi | ecj:JW0765 eco:b0782 |
PATRICi | fig|1411691.4.peg.1496 |
Organism-specific databases
EchoBASEi | EB1553 |
Phylogenomic databases
eggNOGi | COG0521, Bacteria |
HOGENOMi | CLU_077358_2_2_6 |
InParanoidi | P0AEZ9 |
PhylomeDBi | P0AEZ9 |
Enzyme and pathway databases
UniPathwayi | UPA00344 |
BioCyci | EcoCyc:MONOMER0-1501 |
Miscellaneous databases
EvolutionaryTracei | P0AEZ9 |
PROi | PR:P0AEZ9 |
Family and domain databases
CDDi | cd00886, MogA_MoaB, 1 hit |
Gene3Di | 3.40.980.10, 1 hit |
InterProi | View protein in InterPro IPR012245, MoaB IPR036425, MoaB/Mog-like_dom_sf IPR001453, MoaB/Mog_dom IPR013484, MoaB_proteobac IPR008284, MoCF_biosynth_CS |
PANTHERi | PTHR43232, PTHR43232, 1 hit |
Pfami | View protein in Pfam PF00994, MoCF_biosynth, 1 hit |
PIRSFi | PIRSF006443, MoaB, 1 hit |
SMARTi | View protein in SMART SM00852, MoCF_biosynth, 1 hit |
SUPFAMi | SSF53218, SSF53218, 1 hit |
TIGRFAMsi | TIGR02667, moaB_proteo, 1 hit TIGR00177, molyb_syn, 1 hit |
PROSITEi | View protein in PROSITE PS01078, MOCF_BIOSYNTHESIS_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MOAB_ECOLI | |
Accessioni | P0AEZ9Primary (citable) accession number: P0AEZ9 Secondary accession number(s): P30746 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families