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Protein

Modulator of drug activity B

Gene

mdaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: EcoCyc
  • NADPH dehydrogenase (quinone) activity Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:EG12656-MONOMER
MetaCyc:EG12656-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator of drug activity B
Gene namesi
Name:mdaB
Synonyms:mda66
Ordered Locus Names:b3028, JW2996
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12656 mdaB

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963121 – 193Modulator of drug activity BAdd BLAST193

Proteomic databases

PaxDbiP0AEY5
PRIDEiP0AEY5

Interactioni

Protein-protein interaction databases

BioGridi4263034, 19 interactors
IntActiP0AEY5, 3 interactors
STRINGi316385.ECDH10B_3202

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi19 – 34Combined sources16
Beta strandi38 – 46Combined sources9
Helixi50 – 59Combined sources10
Beta strandi61 – 68Combined sources8
Helixi76 – 88Combined sources13
Turni89 – 92Combined sources4
Beta strandi93 – 98Combined sources6
Beta strandi118 – 124Combined sources7
Helixi130 – 133Combined sources4
Turni138 – 141Combined sources4
Helixi144 – 147Combined sources4
Helixi149 – 157Combined sources9
Beta strandi166 – 168Combined sources3
Turni171 – 173Combined sources3
Turni177 – 179Combined sources3
Helixi180 – 192Combined sources13

3D structure databases

ProteinModelPortaliP0AEY5
SMRiP0AEY5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AEY5

Family & Domainsi

Sequence similaritiesi

To H.influenzae HI_0648 and S.pombe SPAC5H10.05c.Curated

Phylogenomic databases

eggNOGiENOG4105NF4 Bacteria
COG2249 LUCA
HOGENOMiHOG000063966
InParanoidiP0AEY5
KOiK03923
OMAiVYLHLHK
PhylomeDBiP0AEY5

Family and domain databases

Gene3Di3.40.50.360, 1 hit
InterProiView protein in InterPro
IPR003680 Flavodoxin_fold
IPR029039 Flavoprotein-like_sf
PfamiView protein in Pfam
PF02525 Flavodoxin_2, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNILIINGA KKFAHSNGQL NDTLTEVADG TLRDLGHDVR IVRADSDYDV
60 70 80 90 100
KAEVQNFLWA DVVIWQMPGW WMGAPWTVKK YIDDVFTEGH GTLYASDGRT
110 120 130 140 150
RKDPSKKYGS GGLVQGKKYM LSLTWNAPME AFTEKDQFFH GVGVDGVYLP
160 170 180 190
FHKANQFLGM EPLPTFIAND VIKMPDVPRY TEEYRKHLVE IFG
Length:193
Mass (Da):21,891
Last modified:December 20, 2005 - v1
Checksum:iFEE3B4D13C2733CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18656 Genomic DNA Translation: AAC43451.1
U28377 Genomic DNA Translation: AAA69196.1
U00096 Genomic DNA Translation: AAC76064.1
AP009048 Genomic DNA Translation: BAE77084.1
PIRiI80319
RefSeqiNP_417500.1, NC_000913.3
WP_000065430.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76064; AAC76064; b3028
BAE77084; BAE77084; BAE77084
GeneIDi947512
KEGGiecj:JW2996
eco:b3028
PATRICifig|1411691.4.peg.3703

Similar proteinsi

Entry informationi

Entry nameiMDAB_ECOLI
AccessioniPrimary (citable) accession number: P0AEY5
Secondary accession number(s): P40717, Q2M9H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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