UniProtKB - P0AEX7 (LIVH_ECOLI)
Protein
High-affinity branched-chain amino acid transport system permease protein LivH
Gene
livH
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.
GO - Molecular functioni
- branched-chain amino acid transmembrane transporter activity Source: EcoCyc
- L-isoleucine transmembrane transporter activity Source: EcoCyc
- L-leucine transmembrane transporter activity Source: EcoCyc
- L-phenylalanine transmembrane transporter activity Source: EcoCyc
- L-valine transmembrane transporter activity Source: EcoCyc
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- branched-chain amino acid transport Source: EcoCyc
- D-alanine transport Source: GO_Central
- isoleucine transmembrane transport Source: EcoCyc
- L-alanine transport Source: GO_Central
- leucine import across plasma membrane Source: EcoCyc
- L-isoleucine import across plasma membrane Source: GO_Central
- L-valine transmembrane transport Source: EcoCyc
- phenylalanine transport Source: EcoCyc
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:LIVH-MONOMER MetaCyc:LIVH-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.4.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: High-affinity branched-chain amino acid transport system permease protein LivHAlternative name(s): LIV-I protein H |
Gene namesi | Name:livH Ordered Locus Names:b3457, JW3422 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 21 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 22 – 42 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 43 – 45 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 46 – 66 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 67 – 68 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 90 – 104 | PeriplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 126 – 154 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 203 | PeriplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 225 – 245 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 246 – 266 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 267 – 280 | PeriplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 281 – 301 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 302 – 308 | CytoplasmicSequence analysis | 7 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060058 | 1 – 308 | High-affinity branched-chain amino acid transport system permease protein LivHAdd BLAST | 308 |
Proteomic databases
PaxDbi | P0AEX7 |
PRIDEi | P0AEX7 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262494, 24 interactors |
ComplexPortali | CPX-4316, Branched chain amino acid ABC transporter complex CPX-4317, Branched chain amino acid, leucine-specific ABC transporter complex |
STRINGi | 511145.b3457 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0559, Bacteria |
HOGENOMi | CLU_039929_3_1_6 |
InParanoidi | P0AEX7 |
PhylomeDBi | P0AEX7 |
Family and domain databases
InterProi | View protein in InterPro IPR001851, ABC_transp_permease |
Pfami | View protein in Pfam PF02653, BPD_transp_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AEX7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEQFLYFLQ QMFNGVTLGS TYALIAIGYT MVYGIIGMIN FAHGEVYMIG
60 70 80 90 100
SYVSFMIIAA LMMMGIDTGW LLVAAGFVGA IVIASAYGWS IERVAYRPVR
110 120 130 140 150
NSKRLIALIS AIGMSIFLQN YVSLTEGSRD VALPSLFNGQ WVVGHSENFS
160 170 180 190 200
ASITTMQAVI WIVTFLAMLA LTIFIRYSRM GRACRACAED LKMASLLGIN
210 220 230 240 250
TDRVIALTFV IGAAMAAVAG VLLGQFYGVI NPYIGFMAGM KAFTAAVLGG
260 270 280 290 300
IGSIPGAMIG GLILGIAEAL SSAYLSTEYK DVVSFALLIL VLLVMPTGIL
GRPEVEKV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 253 | S → G (PubMed:3009409).Curated | 1 | |
Sequence conflicti | 253 | S → G (PubMed:2195019).Curated | 1 | |
Sequence conflicti | 288 | L → P (PubMed:3009409).Curated | 1 | |
Sequence conflicti | 288 | L → P (PubMed:2195019).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05516 Genomic DNA Translation: AAA83884.1 U00039 Genomic DNA Translation: AAB18432.1 U00096 Genomic DNA Translation: AAC76482.1 AP009048 Genomic DNA Translation: BAE77836.1 |
PIRi | S47676, QRECLH |
RefSeqi | NP_417914.1, NC_000913.3 WP_001295111.1, NZ_SSZK01000008.1 |
Genome annotation databases
EnsemblBacteriai | AAC76482; AAC76482; b3457 BAE77836; BAE77836; BAE77836 |
GeneIDi | 58462558 947965 |
KEGGi | ecj:JW3422 eco:b3457 |
PATRICi | fig|1411691.4.peg.3269 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05516 Genomic DNA Translation: AAA83884.1 U00039 Genomic DNA Translation: AAB18432.1 U00096 Genomic DNA Translation: AAC76482.1 AP009048 Genomic DNA Translation: BAE77836.1 |
PIRi | S47676, QRECLH |
RefSeqi | NP_417914.1, NC_000913.3 WP_001295111.1, NZ_SSZK01000008.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4262494, 24 interactors |
ComplexPortali | CPX-4316, Branched chain amino acid ABC transporter complex CPX-4317, Branched chain amino acid, leucine-specific ABC transporter complex |
STRINGi | 511145.b3457 |
Protein family/group databases
TCDBi | 3.A.1.4.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P0AEX7 |
PRIDEi | P0AEX7 |
Genome annotation databases
EnsemblBacteriai | AAC76482; AAC76482; b3457 BAE77836; BAE77836; BAE77836 |
GeneIDi | 58462558 947965 |
KEGGi | ecj:JW3422 eco:b3457 |
PATRICi | fig|1411691.4.peg.3269 |
Organism-specific databases
EchoBASEi | EB0533 |
Phylogenomic databases
eggNOGi | COG0559, Bacteria |
HOGENOMi | CLU_039929_3_1_6 |
InParanoidi | P0AEX7 |
PhylomeDBi | P0AEX7 |
Enzyme and pathway databases
BioCyci | EcoCyc:LIVH-MONOMER MetaCyc:LIVH-MONOMER |
Miscellaneous databases
PROi | PR:P0AEX7 |
Family and domain databases
InterProi | View protein in InterPro IPR001851, ABC_transp_permease |
Pfami | View protein in Pfam PF02653, BPD_transp_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIVH_ECOLI | |
Accessioni | P0AEX7Primary (citable) accession number: P0AEX7 Secondary accession number(s): P08340, Q2M7C0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families