livH

Functionⁱ

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.

GO - Molecular functionⁱ

branched-chain amino acid transmembrane transporter activity
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 323236
L-isoleucine transmembrane transporter activity
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 323236
L-leucine transmembrane transporter activity
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 323236
L-phenylalanine transmembrane transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302
L-valine transmembrane transporter activity
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 323236

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

branched-chain amino acid transport
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 323236
isoleucine transmembrane transport
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 323236
leucine import across plasma membrane
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 323236
L-valine transmembrane transport
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 323236
phenylalanine transport
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Amino-acid transport, Transport

Biological process

Amino-acid transport, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:LIVH-MONOMER MetaCyc:LIVH-MONOMER

BioCycⁱ

EcoCyc:LIVH-MONOMER
MetaCyc:LIVH-MONOMER

Protein family/group databases

TCDBⁱ	3.A.1.4.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.4.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: High-affinity branched-chain amino acid transport system permease protein LivH Alternative name(s): LIV-I protein H
Gene namesⁱ	Name:livH Ordered Locus Names:b3457, JW3422
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10538 livH

EcoGeneⁱ

EG10538 livH

Subcellular locationⁱ

Cell inner membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 21	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	22 – 42	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	43 – 45	PeriplasmicSequence analysis	3
Transmembraneⁱ	46 – 66	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	67 – 68	CytoplasmicSequence analysis	2
Transmembraneⁱ	69 – 89	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	90 – 104	PeriplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	105 – 125	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	126 – 154	CytoplasmicSequence analysisAdd BLAST	29
Transmembraneⁱ	155 – 175	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	176 – 203	PeriplasmicSequence analysisAdd BLAST	28
Transmembraneⁱ	204 – 224	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	225 – 245	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	246 – 266	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	267 – 280	PeriplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	281 – 301	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	302 – 308	CytoplasmicSequence analysis	7

GO - Cellular componentⁱ

integral component of plasma membrane
Source: EcoCyc
Inferred from sequence modelⁱ
- 3009409
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000060058	1 – 308	High-affinity branched-chain amino acid transport system permease protein LivHAdd BLAST		308

Proteomic databases

PaxDbⁱ	P0AEX7
PRIDEⁱ	P0AEX7

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4262494, 24 interactors
STRINGⁱ	316385.ECDH10B_3631

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0AEX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105C32 Bacteria COG0559 LUCA
HOGENOMⁱ	HOG000202530
InParanoidⁱ	P0AEX7
KEGG Orthology (KO) More...KOⁱ	K01997
OMAⁱ	NMGWFLI
PhylomeDBⁱ	P0AEX7

Family and domain databases

InterProⁱ	View protein in InterPro IPR001851 ABC_transp_permease
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02653 BPD_transp_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0AEX7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSEQFLYFLQ QMFNGVTLGS TYALIAIGYT MVYGIIGMIN FAHGEVYMIG 
        60         70         80         90        100
SYVSFMIIAA LMMMGIDTGW LLVAAGFVGA IVIASAYGWS IERVAYRPVR 
       110        120        130        140        150
NSKRLIALIS AIGMSIFLQN YVSLTEGSRD VALPSLFNGQ WVVGHSENFS 
       160        170        180        190        200
ASITTMQAVI WIVTFLAMLA LTIFIRYSRM GRACRACAED LKMASLLGIN 
       210        220        230        240        250
TDRVIALTFV IGAAMAAVAG VLLGQFYGVI NPYIGFMAGM KAFTAAVLGG 
       260        270        280        290        300
IGSIPGAMIG GLILGIAEAL SSAYLSTEYK DVVSFALLIL VLLVMPTGIL 

GRPEVEKV

Length:308

Mass (Da):32,982

Last modified:December 20, 2005 - v1

Checksum:ⁱ8C8A4BD56718A4BE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	253	S → G (PubMed:3009409).Curated	1
Sequence conflictⁱ	253	S → G (PubMed:2195019).Curated	1
Sequence conflictⁱ	288	L → P (PubMed:3009409).Curated	1
Sequence conflictⁱ	288	L → P (PubMed:2195019).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05516 Genomic DNA Translation: AAA83884.1 U00039 Genomic DNA Translation: AAB18432.1 U00096 Genomic DNA Translation: AAC76482.1 AP009048 Genomic DNA Translation: BAE77836.1
PIRⁱ	S47676 QRECLH
NCBI Reference Sequences More...RefSeqⁱ	NP_417914.1, NC_000913.3 WP_001295111.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC76482; AAC76482; b3457 BAE77836; BAE77836; BAE77836
GeneIDⁱ	947965
KEGGⁱ	ecj:JW3422 eco:b3457
PATRICⁱ	fig\|1411691.4.peg.3269

Protein	Similar proteins		Species	Score	Length
P0AEX7	High-affinity branched-chain amino acid transport system permease protein LivH		ECO57		308
Leucine/isoleucine/valine transporter subunit membrane component of ABC superfamily		Escherichia coli NCCP15648		308
High-affinity branched-chain amino acid transport system		Escherichia coli D6-113.11		308
Branched-chain amino acid ABC transporter permease		Escherichia coli M8		308
Branched-chain amino acid ABC transporter permease		SHIBO		308
+111

Protein	Similar proteins		Species	Score	Length
P0AEX7	High-affinity branched-chain amino acid transport system permease protein LivH		SALTI		308
High-affinity branched-chain amino acid transport system permease protein LivH		SALTY		308
Branched-chain amino acid ABC transporter permease		SALON		308
Branched-chain amino acid ABC transporter permease		SALMO		308
Branched-chain amino acid ABC transporter permease		Salmonella enterica subsp. enterica serovar 4,12:i:-		308
+892

Protein	Similar proteins		Species	Score	Length
P0AEX7	High-affinity branched-chain amino acid transport system permease protein LivH		SALTI		308
High-affinity branched-chain amino acid transport system permease protein LivH		SALTY		308
Branched-chain amino acid ABC transporter permease		SALON		308
Branched-chain amino acid ABC transporter permease		SALMO		308
Branched-chain amino acid ABC transporter permease		Salmonella enterica subsp. enterica serovar 4,12:i:-		308
+4437

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05516 Genomic DNA Translation: AAA83884.1 U00039 Genomic DNA Translation: AAB18432.1 U00096 Genomic DNA Translation: AAC76482.1 AP009048 Genomic DNA Translation: BAE77836.1
PIRⁱ	S47676 QRECLH
NCBI Reference Sequences More...RefSeqⁱ	NP_417914.1, NC_000913.3 WP_001295111.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0AEX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4262494, 24 interactors
STRINGⁱ	316385.ECDH10B_3631

Protein family/group databases

TCDBⁱ	3.A.1.4.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.4.1 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbⁱ	P0AEX7
PRIDEⁱ	P0AEX7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC76482; AAC76482; b3457 BAE77836; BAE77836; BAE77836
GeneIDⁱ	947965
KEGGⁱ	ecj:JW3422 eco:b3457
PATRICⁱ	fig\|1411691.4.peg.3269

Organism-specific databases

EchoBASEⁱ	EB0533
EcoGeneⁱ	EG10538 livH

Phylogenomic databases

eggNOGⁱ	ENOG4105C32 Bacteria COG0559 LUCA
HOGENOMⁱ	HOG000202530
InParanoidⁱ	P0AEX7
KEGG Orthology (KO) More...KOⁱ	K01997
OMAⁱ	NMGWFLI
PhylomeDBⁱ	P0AEX7

Enzyme and pathway databases

BioCycⁱ	EcoCyc:LIVH-MONOMER MetaCyc:LIVH-MONOMER

BioCycⁱ

EcoCyc:LIVH-MONOMER
MetaCyc:LIVH-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0AEX7

PROⁱ

PR:P0AEX7

Family and domain databases

InterProⁱ	View protein in InterPro IPR001851 ABC_transp_permease
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02653 BPD_transp_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LIVH_ECOLI
Accessionⁱ	P0AEX7Primary (citable) accession number: P0AEX7 Secondary accession number(s): P08340, Q2M7C0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	December 20, 2005
	Last modified:	March 28, 2018
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0AEX7 (LIVH_ECOLI)

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High-affinity branched-chain amino acid transport system permease protein LivH

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ