High-affinity branched-chain amino acid transport system permease protein LivH

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• branched-chain amino acid transmembrane transporter activity Source: EcoCyc <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Escherichia coli transport mutants lacking binding protein and other components of the branched-chain amino acid transport systems."
    Anderson J.J., Oxender D.L.
    J. Bacteriol. 130:384-392(1977) [PubMed] [Europe PMC] [Abstract]
• L-isoleucine transmembrane transporter activity Source: EcoCycInferred from mutant phenotypeⁱ
  • "Escherichia coli transport mutants lacking binding protein and other components of the branched-chain amino acid transport systems."
    Anderson J.J., Oxender D.L.
    J. Bacteriol. 130:384-392(1977) [PubMed] [Europe PMC] [Abstract]
• L-leucine transmembrane transporter activity Source: EcoCycInferred from mutant phenotypeⁱ
  • "Escherichia coli transport mutants lacking binding protein and other components of the branched-chain amino acid transport systems."
    Anderson J.J., Oxender D.L.
    J. Bacteriol. 130:384-392(1977) [PubMed] [Europe PMC] [Abstract]
• L-phenylalanine transmembrane transporter activity Source: EcoCyc <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of the LIV-I/LS system as the third phenylalanine transporter in Escherichia coli K-12."
    Koyanagi T., Katayama T., Suzuki H., Kumagai H.
    J. Bacteriol. 186:343-350(2004) [PubMed] [Europe PMC] [Abstract]
• L-valine transmembrane transporter activity Source: EcoCycInferred from mutant phenotypeⁱ
  • "Escherichia coli transport mutants lacking binding protein and other components of the branched-chain amino acid transport systems."
    Anderson J.J., Oxender D.L.
    J. Bacteriol. 130:384-392(1977) [PubMed] [Europe PMC] [Abstract]
• transmembrane transporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• branched-chain amino acid transport Source: EcoCycInferred from mutant phenotypeⁱ
  • "Escherichia coli transport mutants lacking binding protein and other components of the branched-chain amino acid transport systems."
    Anderson J.J., Oxender D.L.
    J. Bacteriol. 130:384-392(1977) [PubMed] [Europe PMC] [Abstract]
• D-alanine transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• isoleucine transmembrane transport Source: EcoCycInferred from mutant phenotypeⁱ
  • "Escherichia coli transport mutants lacking binding protein and other components of the branched-chain amino acid transport systems."
    Anderson J.J., Oxender D.L.
    J. Bacteriol. 130:384-392(1977) [PubMed] [Europe PMC] [Abstract]
• L-alanine transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• leucine import across plasma membrane Source: EcoCycInferred from mutant phenotypeⁱ
  • "Escherichia coli transport mutants lacking binding protein and other components of the branched-chain amino acid transport systems."
    Anderson J.J., Oxender D.L.
    J. Bacteriol. 130:384-392(1977) [PubMed] [Europe PMC] [Abstract]
• L-isoleucine import across plasma membrane Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• L-valine transmembrane transport Source: EcoCycInferred from mutant phenotypeⁱ
  • "Escherichia coli transport mutants lacking binding protein and other components of the branched-chain amino acid transport systems."
    Anderson J.J., Oxender D.L.
    J. Bacteriol. 130:384-392(1977) [PubMed] [Europe PMC] [Abstract]
• phenylalanine transport Source: EcoCycInferred from direct assayⁱ
  • "Identification of the LIV-I/LS system as the third phenylalanine transporter in Escherichia coli K-12."
    Koyanagi T., Katayama T., Suzuki H., Kumagai H.
    J. Bacteriol. 186:343-350(2004) [PubMed] [Europe PMC] [Abstract]
• transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

• integral component of plasma membrane Source: EcoCycInferred from sequence modelⁱ
  • Ref.1

    "Cloning and characterization of livH, the structural gene encoding a component of the leucine transport system in Escherichia coli."
    Nazos P.M., Antonucci T.K., Landick R., Oxender D.L.
    J. Bacteriol. 166:565-573(1986) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• plasma membrane Source: EcoCycInferred from direct assayⁱ
  • Ref.6

    "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSEQFLYFLQ QMFNGVTLGS TYALIAIGYT MVYGIIGMIN FAHGEVYMIG 
        60         70         80         90        100
SYVSFMIIAA LMMMGIDTGW LLVAAGFVGA IVIASAYGWS IERVAYRPVR 
       110        120        130        140        150
NSKRLIALIS AIGMSIFLQN YVSLTEGSRD VALPSLFNGQ WVVGHSENFS 
       160        170        180        190        200
ASITTMQAVI WIVTFLAMLA LTIFIRYSRM GRACRACAED LKMASLLGIN 
       210        220        230        240        250
TDRVIALTFV IGAAMAAVAG VLLGQFYGVI NPYIGFMAGM KAFTAAVLGG 
       260        270        280        290        300
IGSIPGAMIG GLILGIAEAL SSAYLSTEYK DVVSFALLIL VLLVMPTGIL 

GRPEVEKV                                               

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families