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Entry version 114 (02 Dec 2020)
Sequence version 1 (20 Dec 2005)
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Protein

Alpha-ketoglutarate permease

Gene

kgtP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • solute:cation symporter activity Source: EcoCyc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:KGTP-MONOMER
MetaCyc:KGTP-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.6.2, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-ketoglutarate permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kgtP
Synonyms:witA
Ordered Locus Names:b2587, JW2571
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32Cytoplasmic1 PublicationAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53Helical; Name=1CuratedAdd BLAST21
Topological domaini54 – 62Periplasmic1 Publication9
Transmembranei63 – 83Helical; Name=2CuratedAdd BLAST21
Topological domaini84 – 95Cytoplasmic1 PublicationAdd BLAST12
Transmembranei96 – 116Helical; Name=3CuratedAdd BLAST21
Topological domaini117 – 118Periplasmic1 Publication2
Transmembranei119 – 139Helical; Name=4CuratedAdd BLAST21
Topological domaini140 – 162Cytoplasmic1 PublicationAdd BLAST23
Transmembranei163 – 183Helical; Name=5CuratedAdd BLAST21
Topological domaini184 – 193Periplasmic1 Publication10
Transmembranei194 – 214Helical; Name=6CuratedAdd BLAST21
Topological domaini215 – 243Cytoplasmic1 PublicationAdd BLAST29
Transmembranei244 – 264Helical; Name=7CuratedAdd BLAST21
Topological domaini265 – 279Periplasmic1 PublicationAdd BLAST15
Transmembranei280 – 300Helical; Name=8CuratedAdd BLAST21
Topological domaini301 – 309Cytoplasmic1 Publication9
Transmembranei310 – 330Helical; Name=9CuratedAdd BLAST21
Topological domaini331 – 339Periplasmic1 Publication9
Transmembranei340 – 360Helical; Name=10CuratedAdd BLAST21
Topological domaini361 – 373Cytoplasmic1 PublicationAdd BLAST13
Transmembranei374 – 394Helical; Name=11CuratedAdd BLAST21
Topological domaini395 – 402Periplasmic1 Publication8
Transmembranei403 – 423Helical; Name=12CuratedAdd BLAST21
Topological domaini424 – 432Cytoplasmic1 Publication9

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503061 – 432Alpha-ketoglutarate permeaseAdd BLAST432

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0AEX3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0AEX3

PRoteomics IDEntifications database

More...
PRIDEi
P0AEX3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260613, 10 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2587

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0477, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001265_39_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0AEX3

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0AEX3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR004736, MHS_symport
IPR005829, Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083, Sugar_tr, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00883, 2A0106, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit
PS00217, SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0AEX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESTVTADS KLTSSDTRRR IWAIVGASSG NLVEWFDFYV YSFCSLYFAH
60 70 80 90 100
IFFPSGNTTT QLLQTAGVFA AGFLMRPIGG WLFGRIADKH GRKKSMLLSV
110 120 130 140 150
CMMCFGSLVI ACLPGYETIG TWAPALLLLA RLFQGLSVGG EYGTSATYMS
160 170 180 190 200
EVAVEGRKGF YASFQYVTLI GGQLLALLVV VVLQHTMEDA ALREWGWRIP
210 220 230 240 250
FALGAVLAVV ALWLRRQLDE TSQQETRALK EAGSLKGLWR NRRAFIMVLG
260 270 280 290 300
FTAAGSLCFY TFTTYMQKYL VNTAGMHANV ASGIMTAALF VFMLIQPLIG
310 320 330 340 350
ALSDKIGRRT SMLCFGSLAA IFTVPILSAL QNVSSPYAAF GLVMCALLIV
360 370 380 390 400
SFYTSISGIL KAEMFPAQVR ALGVGLSYAV ANAIFGGSAE YVALSLKSIG
410 420 430
METAFFWYVT LMAVVAFLVS LMLHRKGKGM RL
Length:432
Mass (Da):47,052
Last modified:December 20, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i264B8473195765DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X53027 Genomic DNA Translation: CAA37198.1
U00096 Genomic DNA Translation: AAC75640.1
AP009048 Genomic DNA Translation: BAA16472.1
X56780 Genomic DNA Translation: CAA40099.1 Different termination.
X52363 Genomic DNA Translation: CAA36589.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JN0080

NCBI Reference Sequences

More...
RefSeqi
NP_417082.1, NC_000913.3
WP_000841103.1, NZ_STEB01000011.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75640; AAC75640; b2587
BAA16472; BAA16472; BAA16472

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
48726545
947069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2571
eco:b2587

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.4147

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53027 Genomic DNA Translation: CAA37198.1
U00096 Genomic DNA Translation: AAC75640.1
AP009048 Genomic DNA Translation: BAA16472.1
X56780 Genomic DNA Translation: CAA40099.1 Different termination.
X52363 Genomic DNA Translation: CAA36589.1
PIRiJN0080
RefSeqiNP_417082.1, NC_000913.3
WP_000841103.1, NZ_STEB01000011.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4260613, 10 interactors
STRINGi511145.b2587

Protein family/group databases

TCDBi2.A.1.6.2, the major facilitator superfamily (mfs)

Proteomic databases

jPOSTiP0AEX3
PaxDbiP0AEX3
PRIDEiP0AEX3

Genome annotation databases

EnsemblBacteriaiAAC75640; AAC75640; b2587
BAA16472; BAA16472; BAA16472
GeneIDi48726545
947069
KEGGiecj:JW2571
eco:b2587
PATRICifig|1411691.4.peg.4147

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0517

Phylogenomic databases

eggNOGiCOG0477, Bacteria
HOGENOMiCLU_001265_39_0_6
InParanoidiP0AEX3
PhylomeDBiP0AEX3

Enzyme and pathway databases

BioCyciEcoCyc:KGTP-MONOMER
MetaCyc:KGTP-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0AEX3

Family and domain databases

InterProiView protein in InterPro
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR004736, MHS_symport
IPR005829, Sugar_transporter_CS
PfamiView protein in Pfam
PF00083, Sugar_tr, 2 hits
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00883, 2A0106, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit
PS00217, SUGAR_TRANSPORT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKGTP_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AEX3
Secondary accession number(s): P17448
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: December 2, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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