UniProtKB - P0AEX3 (KGTP_ECOLI)
Protein
Alpha-ketoglutarate permease
Gene
kgtP
Organism
Escherichia coli (strain K12)
Status
Functioni
Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system).1 Publication
GO - Molecular functioni
- solute:cation symporter activity Source: EcoCyc
Keywordsi
Biological process | Symport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:KGTP-MONOMER MetaCyc:KGTP-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.6.2, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-ketoglutarate permease |
Gene namesi | Name:kgtP Synonyms:witA Ordered Locus Names:b2587, JW2571 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | Cytoplasmic1 PublicationAdd BLAST | 32 | |
Transmembranei | 33 – 53 | Helical; Name=1CuratedAdd BLAST | 21 | |
Topological domaini | 54 – 62 | Periplasmic1 Publication | 9 | |
Transmembranei | 63 – 83 | Helical; Name=2CuratedAdd BLAST | 21 | |
Topological domaini | 84 – 95 | Cytoplasmic1 PublicationAdd BLAST | 12 | |
Transmembranei | 96 – 116 | Helical; Name=3CuratedAdd BLAST | 21 | |
Topological domaini | 117 – 118 | Periplasmic1 Publication | 2 | |
Transmembranei | 119 – 139 | Helical; Name=4CuratedAdd BLAST | 21 | |
Topological domaini | 140 – 162 | Cytoplasmic1 PublicationAdd BLAST | 23 | |
Transmembranei | 163 – 183 | Helical; Name=5CuratedAdd BLAST | 21 | |
Topological domaini | 184 – 193 | Periplasmic1 Publication | 10 | |
Transmembranei | 194 – 214 | Helical; Name=6CuratedAdd BLAST | 21 | |
Topological domaini | 215 – 243 | Cytoplasmic1 PublicationAdd BLAST | 29 | |
Transmembranei | 244 – 264 | Helical; Name=7CuratedAdd BLAST | 21 | |
Topological domaini | 265 – 279 | Periplasmic1 PublicationAdd BLAST | 15 | |
Transmembranei | 280 – 300 | Helical; Name=8CuratedAdd BLAST | 21 | |
Topological domaini | 301 – 309 | Cytoplasmic1 Publication | 9 | |
Transmembranei | 310 – 330 | Helical; Name=9CuratedAdd BLAST | 21 | |
Topological domaini | 331 – 339 | Periplasmic1 Publication | 9 | |
Transmembranei | 340 – 360 | Helical; Name=10CuratedAdd BLAST | 21 | |
Topological domaini | 361 – 373 | Cytoplasmic1 PublicationAdd BLAST | 13 | |
Transmembranei | 374 – 394 | Helical; Name=11CuratedAdd BLAST | 21 | |
Topological domaini | 395 – 402 | Periplasmic1 Publication | 8 | |
Transmembranei | 403 – 423 | Helical; Name=12CuratedAdd BLAST | 21 | |
Topological domaini | 424 – 432 | Cytoplasmic1 Publication | 9 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050306 | 1 – 432 | Alpha-ketoglutarate permeaseAdd BLAST | 432 |
Proteomic databases
jPOSTi | P0AEX3 |
PaxDbi | P0AEX3 |
PRIDEi | P0AEX3 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260613, 10 interactors |
STRINGi | 511145.b2587 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0477, Bacteria |
HOGENOMi | CLU_001265_39_0_6 |
InParanoidi | P0AEX3 |
PhylomeDBi | P0AEX3 |
Family and domain databases
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004736, MHS_symport IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 2 hits |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00883, 2A0106, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AEX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAESTVTADS KLTSSDTRRR IWAIVGASSG NLVEWFDFYV YSFCSLYFAH
60 70 80 90 100
IFFPSGNTTT QLLQTAGVFA AGFLMRPIGG WLFGRIADKH GRKKSMLLSV
110 120 130 140 150
CMMCFGSLVI ACLPGYETIG TWAPALLLLA RLFQGLSVGG EYGTSATYMS
160 170 180 190 200
EVAVEGRKGF YASFQYVTLI GGQLLALLVV VVLQHTMEDA ALREWGWRIP
210 220 230 240 250
FALGAVLAVV ALWLRRQLDE TSQQETRALK EAGSLKGLWR NRRAFIMVLG
260 270 280 290 300
FTAAGSLCFY TFTTYMQKYL VNTAGMHANV ASGIMTAALF VFMLIQPLIG
310 320 330 340 350
ALSDKIGRRT SMLCFGSLAA IFTVPILSAL QNVSSPYAAF GLVMCALLIV
360 370 380 390 400
SFYTSISGIL KAEMFPAQVR ALGVGLSYAV ANAIFGGSAE YVALSLKSIG
410 420 430
METAFFWYVT LMAVVAFLVS LMLHRKGKGM RL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53027 Genomic DNA Translation: CAA37198.1 U00096 Genomic DNA Translation: AAC75640.1 AP009048 Genomic DNA Translation: BAA16472.1 X56780 Genomic DNA Translation: CAA40099.1 Different termination. X52363 Genomic DNA Translation: CAA36589.1 |
PIRi | JN0080 |
RefSeqi | NP_417082.1, NC_000913.3 WP_000841103.1, NZ_STEB01000011.1 |
Genome annotation databases
EnsemblBacteriai | AAC75640; AAC75640; b2587 BAA16472; BAA16472; BAA16472 |
GeneIDi | 48726545 947069 |
KEGGi | ecj:JW2571 eco:b2587 |
PATRICi | fig|1411691.4.peg.4147 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53027 Genomic DNA Translation: CAA37198.1 U00096 Genomic DNA Translation: AAC75640.1 AP009048 Genomic DNA Translation: BAA16472.1 X56780 Genomic DNA Translation: CAA40099.1 Different termination. X52363 Genomic DNA Translation: CAA36589.1 |
PIRi | JN0080 |
RefSeqi | NP_417082.1, NC_000913.3 WP_000841103.1, NZ_STEB01000011.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260613, 10 interactors |
STRINGi | 511145.b2587 |
Protein family/group databases
TCDBi | 2.A.1.6.2, the major facilitator superfamily (mfs) |
Proteomic databases
jPOSTi | P0AEX3 |
PaxDbi | P0AEX3 |
PRIDEi | P0AEX3 |
Genome annotation databases
EnsemblBacteriai | AAC75640; AAC75640; b2587 BAA16472; BAA16472; BAA16472 |
GeneIDi | 48726545 947069 |
KEGGi | ecj:JW2571 eco:b2587 |
PATRICi | fig|1411691.4.peg.4147 |
Organism-specific databases
EchoBASEi | EB0517 |
Phylogenomic databases
eggNOGi | COG0477, Bacteria |
HOGENOMi | CLU_001265_39_0_6 |
InParanoidi | P0AEX3 |
PhylomeDBi | P0AEX3 |
Enzyme and pathway databases
BioCyci | EcoCyc:KGTP-MONOMER MetaCyc:KGTP-MONOMER |
Miscellaneous databases
PROi | PR:P0AEX3 |
Family and domain databases
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004736, MHS_symport IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 2 hits |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00883, 2A0106, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KGTP_ECOLI | |
Accessioni | P0AEX3Primary (citable) accession number: P0AEX3 Secondary accession number(s): P17448 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | December 2, 2020 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families