UniProtKB - P0AEV4 (HYCA_ECOLI)
Protein
Formate hydrogenlyase regulatory protein HycA
Gene
hycA
Organism
Escherichia coli (strain K12)
Status
Functioni
Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence (PubMed:1625581). Also down-regulates expression of the hyf operon (PubMed:12426353).2 Publications
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10474-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Formate hydrogenlyase regulatory protein HycA |
Gene namesi | Name:hycA Synonyms:hevA Ordered Locus Names:b2725, JW2695 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Increased expression of the hyf operon (PubMed:12426353).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084100 | 1 – 153 | Formate hydrogenlyase regulatory protein HycAAdd BLAST | 153 |
Proteomic databases
PaxDbi | P0AEV4 |
PRIDEi | P0AEV4 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262102, 11 interactors 851525, 1 interactor |
IntActi | P0AEV4, 1 interactor |
STRINGi | 511145.b2725 |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG50305VH, Bacteria |
HOGENOMi | CLU_115336_0_0_6 |
Family and domain databases
InterProi | View protein in InterPro IPR021285, Tscrpt_reg_HycA |
Pfami | View protein in Pfam PF11046, HycA_repressor, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AEV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTIWEISEKA DYIAQRHRRL QDQWHIYCNS LVQGITLSKA RLHHAMSCAP
60 70 80 90 100
DKELCFVLFE HFRIYVTLAD GFNSHTIEYY VETKDGEDKQ RIAQAQLSID
110 120 130 140 150
GMIDGKVNIR DREQVLEHYL EKIAGVYDSL YTAIENNVPV NLSQLVKGQS
PAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17506 Genomic DNA Translation: CAA35546.1 U29579 Genomic DNA Translation: AAA69235.1 U00096 Genomic DNA Translation: AAC75767.1 AP009048 Genomic DNA Translation: BAE76802.1 |
PIRi | S08619 |
RefSeqi | NP_417205.1, NC_000913.3 WP_000158056.1, NZ_STEB01000027.1 |
Genome annotation databases
EnsemblBacteriai | AAC75767; AAC75767; b2725 BAE76802; BAE76802; BAE76802 |
GeneIDi | 48109255 947193 |
KEGGi | ecj:JW2695 eco:b2725 |
PATRICi | fig|1411691.4.peg.4016 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17506 Genomic DNA Translation: CAA35546.1 U29579 Genomic DNA Translation: AAA69235.1 U00096 Genomic DNA Translation: AAC75767.1 AP009048 Genomic DNA Translation: BAE76802.1 |
PIRi | S08619 |
RefSeqi | NP_417205.1, NC_000913.3 WP_000158056.1, NZ_STEB01000027.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4262102, 11 interactors 851525, 1 interactor |
IntActi | P0AEV4, 1 interactor |
STRINGi | 511145.b2725 |
Proteomic databases
PaxDbi | P0AEV4 |
PRIDEi | P0AEV4 |
Genome annotation databases
EnsemblBacteriai | AAC75767; AAC75767; b2725 BAE76802; BAE76802; BAE76802 |
GeneIDi | 48109255 947193 |
KEGGi | ecj:JW2695 eco:b2725 |
PATRICi | fig|1411691.4.peg.4016 |
Organism-specific databases
EchoBASEi | EB0469 |
Phylogenomic databases
eggNOGi | ENOG50305VH, Bacteria |
HOGENOMi | CLU_115336_0_0_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10474-MONOMER |
Miscellaneous databases
PROi | PR:P0AEV4 |
Family and domain databases
InterProi | View protein in InterPro IPR021285, Tscrpt_reg_HycA |
Pfami | View protein in Pfam PF11046, HycA_repressor, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HYCA_ECOLI | |
Accessioni | P0AEV4Primary (citable) accession number: P0AEV4 Secondary accession number(s): P16427, Q2MAA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |