UniProtKB - P0AEU3 (HISM_ECOLI)
Protein
Histidine transport system permease protein HisM
Gene
hisM
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity).By similarity
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- amino acid transport Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:HISM-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.3.29, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Histidine transport system permease protein HisM |
Gene namesi | Name:hisM Ordered Locus Names:b2307, JW2304 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein PROSITE-ProRule annotation1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | PeriplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 47 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 48 – 58 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 59 – 79 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 80 – 104 | PeriplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 105 – 125 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 126 – 157 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 158 – 178 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 179 – 200 | PeriplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 201 – 221 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 222 – 238 | CytoplasmicSequence analysisAdd BLAST | 17 |
GO - Cellular componenti
- ATP-binding cassette (ABC) transporter complex Source: InterPro
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060044 | 1 – 238 | Histidine transport system permease protein HisMAdd BLAST | 238 |
Proteomic databases
PaxDbi | P0AEU3 |
PRIDEi | P0AEU3 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).
By similarityProtein-protein interaction databases
BioGRIDi | 4260522, 5 interactors |
ComplexPortali | CPX-4328, Histidine ABC transporter complex CPX-4329, Polar amino acid ABC transporter complex |
STRINGi | 511145.b2307 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 221 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 199 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG4160, Bacteria |
HOGENOMi | CLU_019602_1_4_6 |
InParanoidi | P0AEU3 |
PhylomeDBi | P0AEU3 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR010065, AA_ABC_transptr_permease_3TM IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
TIGRFAMsi | TIGR01726, HEQRo_perm_3TM, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AEU3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIEILHEYWK PLLWTDGYRF TGVAITLWLL ILSVVIGGVL ALFLAIGRVS
60 70 80 90 100
SNKYIQFPIW LFTYIFRGTP LYVQLLVFYS GMYTLEIVKG TEFLNAFFRS
110 120 130 140 150
GLNCTVLALT LNTCAYTTEI FAGAIRSVPH GEIEAARAYG FSTFKMYRCI
160 170 180 190 200
ILPSALRIAL PAYSNEVILM LHSTALAFTA TVPDLLKIAR DINAATYQPF
210 220 230
TAFGIAAVLY LIISYVLISL FRRAEKRWLQ HVKPSSTH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75367.1 AP009048 Genomic DNA Translation: BAA16153.1 U47027 Genomic DNA Translation: AAA85771.1 Y00455 Genomic DNA Translation: CAA68510.1 |
PIRi | A65003, B27835 |
RefSeqi | NP_416810.1, NC_000913.3 WP_000569958.1, NZ_STEB01000008.1 |
Genome annotation databases
EnsemblBacteriai | AAC75367; AAC75367; b2307 BAA16153; BAA16153; BAA16153 |
GeneIDi | 49583878 946790 |
KEGGi | ecj:JW2304 eco:b2307 |
PATRICi | fig|1411691.4.peg.4427 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75367.1 AP009048 Genomic DNA Translation: BAA16153.1 U47027 Genomic DNA Translation: AAA85771.1 Y00455 Genomic DNA Translation: CAA68510.1 |
PIRi | A65003, B27835 |
RefSeqi | NP_416810.1, NC_000913.3 WP_000569958.1, NZ_STEB01000008.1 |
3D structure databases
SMRi | P0AEU3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260522, 5 interactors |
ComplexPortali | CPX-4328, Histidine ABC transporter complex CPX-4329, Polar amino acid ABC transporter complex |
STRINGi | 511145.b2307 |
Protein family/group databases
TCDBi | 3.A.1.3.29, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P0AEU3 |
PRIDEi | P0AEU3 |
Genome annotation databases
EnsemblBacteriai | AAC75367; AAC75367; b2307 BAA16153; BAA16153; BAA16153 |
GeneIDi | 49583878 946790 |
KEGGi | ecj:JW2304 eco:b2307 |
PATRICi | fig|1411691.4.peg.4427 |
Organism-specific databases
EchoBASEi | EB0007 |
Phylogenomic databases
eggNOGi | COG4160, Bacteria |
HOGENOMi | CLU_019602_1_4_6 |
InParanoidi | P0AEU3 |
PhylomeDBi | P0AEU3 |
Enzyme and pathway databases
BioCyci | EcoCyc:HISM-MONOMER |
Miscellaneous databases
PROi | PR:P0AEU3 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR010065, AA_ABC_transptr_permease_3TM IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
TIGRFAMsi | TIGR01726, HEQRo_perm_3TM, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HISM_ECOLI | |
Accessioni | P0AEU3Primary (citable) accession number: P0AEU3 Secondary accession number(s): P20091, P76936 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | December 2, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families