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Entry version 110 (13 Nov 2019)
Sequence version 1 (20 Dec 2005)
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Protein

Sodium/glutamate symporter

Gene

gltS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the sodium-dependent, binding-protein-independent transport of glutamate.UniRule annotation3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the uncoupler carbonylcyanide m-chlorophenylhydrazone (CCCP) and the ionophore monensin.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=5.2 nmol/min/mg enzyme1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Ion transport, Sodium transport, Symport, Transport
    LigandSodium

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:GLTS-MONOMER
    ECOL316407:JW3628-MONOMER
    MetaCyc:GLTS-MONOMER

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.27.1.1 the glutamate:na(+) symporter (ess) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sodium/glutamate symporterUniRule annotationCurated
    Alternative name(s):
    Glutamate permease1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:gltSUniRule annotation
    Synonyms:gltC
    Ordered Locus Names:b3653, JW3628
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6Periplasmic2 Publications6
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 24HelicalSequence analysisAdd BLAST18
    Topological domaini25 – 32Cytoplasmic2 Publications8
    Transmembranei33 – 52HelicalSequence analysisAdd BLAST20
    Topological domaini53 – 69Periplasmic2 PublicationsAdd BLAST17
    Transmembranei70 – 87HelicalSequence analysisAdd BLAST18
    Topological domaini88 – 93Cytoplasmic2 Publications6
    Transmembranei94 – 116HelicalSequence analysisAdd BLAST23
    Topological domaini117 – 156Periplasmic1 PublicationAdd BLAST40
    Transmembranei157 – 179HelicalSequence analysisAdd BLAST23
    Topological domaini180 – 212Cytoplasmic1 PublicationAdd BLAST33
    Transmembranei213 – 235HelicalSequence analysisAdd BLAST23
    Topological domaini236 – 244Periplasmic2 Publications9
    Transmembranei245 – 267HelicalSequence analysisAdd BLAST23
    Topological domaini268 – 276Cytoplasmic2 Publications9
    Transmembranei277 – 292HelicalSequence analysisAdd BLAST16
    Topological domaini293 – 301Periplasmic2 Publications9
    Transmembranei302 – 324HelicalSequence analysisAdd BLAST23
    Topological domaini325 – 367Cytoplasmic2 PublicationsAdd BLAST43
    Transmembranei368 – 390HelicalSequence analysisAdd BLAST23
    Topological domaini391 – 401Periplasmic2 Publications1 PublicationAdd BLAST11

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523321 – 401Sodium/glutamate symporterAdd BLAST401

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P0AER8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P0AER8

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4262574, 14 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-48023N

    Protein interaction database and analysis system

    More...
    IntActi
    P0AER8, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b3653

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. [View classification]UniRule annotationCurated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105D6U Bacteria
    COG0786 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000282013

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P0AER8

    KEGG Orthology (KO)

    More...
    KOi
    K03312

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P0AER8

    Family and domain databases

    HAMAP database of protein families

    More...
    HAMAPi
    MF_02062 GltS, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR004445 GltS

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR36178 PTHR36178, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03616 Glt_symporter, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00210 gltS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P0AER8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MFHLDTLATL VAATLTLLLG RKLVHSVSFL KKYTIPEPVA GGLLVALALL
    60 70 80 90 100
    VLKKSMGWEV NFDMSLRDPL MLAFFATIGL NANIASLRAG GRVVGIFLIV
    110 120 130 140 150
    VVGLLVMQNA IGIGMASLLG LDPLMGLLAG SITLSGGHGT GAAWSKLFIE
    160 170 180 190 200
    RYGFTNATEV AMACATFGLV LGGLIGGPVA RYLVKHSTTP NGIPDDQEVP
    210 220 230 240 250
    TAFEKPDVGR MITSLVLIET IALIAICLTV GKIVAQLLAG TAFELPTFVC
    260 270 280 290 300
    VLFVGVILSN GLSIMGFYRV FERAVSVLGN VSLSLFLAMA LMGLKLWELA
    310 320 330 340 350
    SLALPMLAIL VVQTIFMALY AIFVTWRMMG KNYDAAVLAA GHCGFGLGAT
    360 370 380 390 400
    PTAIANMQAI TERFGPSHMA FLVVPMVGAF FIDIVNALVI KLYLMLPIFA

    G
    Length:401
    Mass (Da):42,425
    Last modified:December 20, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9569AE0AF75634EC
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti378G → S in BAA00517 (PubMed:2254324).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D00626 Genomic DNA Translation: BAA00517.1
    X17499 Genomic DNA Translation: CAA35540.1
    L10328 Genomic DNA Translation: AAA62006.1
    U00096 Genomic DNA Translation: AAC76677.1
    AP009048 Genomic DNA Translation: BAE77640.1
    M64367 Genomic DNA Translation: AAA24514.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    G65166 YOECNQ

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_418110.1, NC_000913.3
    WP_000468833.1, NZ_SSZK01000043.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC76677; AAC76677; b3653
    BAE77640; BAE77640; BAE77640

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    948166

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW3628
    eco:b3653

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.3053

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D00626 Genomic DNA Translation: BAA00517.1
    X17499 Genomic DNA Translation: CAA35540.1
    L10328 Genomic DNA Translation: AAA62006.1
    U00096 Genomic DNA Translation: AAC76677.1
    AP009048 Genomic DNA Translation: BAE77640.1
    M64367 Genomic DNA Translation: AAA24514.1
    PIRiG65166 YOECNQ
    RefSeqiNP_418110.1, NC_000913.3
    WP_000468833.1, NZ_SSZK01000043.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi4262574, 14 interactors
    DIPiDIP-48023N
    IntActiP0AER8, 1 interactor
    STRINGi511145.b3653

    Protein family/group databases

    TCDBi2.A.27.1.1 the glutamate:na(+) symporter (ess) family

    Proteomic databases

    PaxDbiP0AER8
    PRIDEiP0AER8

    Genome annotation databases

    EnsemblBacteriaiAAC76677; AAC76677; b3653
    BAE77640; BAE77640; BAE77640
    GeneIDi948166
    KEGGiecj:JW3628
    eco:b3653
    PATRICifig|1411691.4.peg.3053

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0401

    Phylogenomic databases

    eggNOGiENOG4105D6U Bacteria
    COG0786 LUCA
    HOGENOMiHOG000282013
    InParanoidiP0AER8
    KOiK03312
    PhylomeDBiP0AER8

    Enzyme and pathway databases

    BioCyciEcoCyc:GLTS-MONOMER
    ECOL316407:JW3628-MONOMER
    MetaCyc:GLTS-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P0AER8

    Family and domain databases

    HAMAPiMF_02062 GltS, 1 hit
    InterProiView protein in InterPro
    IPR004445 GltS
    PANTHERiPTHR36178 PTHR36178, 1 hit
    PfamiView protein in Pfam
    PF03616 Glt_symporter, 1 hit
    TIGRFAMsiTIGR00210 gltS, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLTS_ECOLI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0AER8
    Secondary accession number(s): P19933, Q2M7W6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: November 13, 2019
    This is version 110 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
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