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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galU

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in stationary phase survival.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Cofactori

GO - Molecular functioni

  • identical protein binding Source: EcoCyc
  • magnesium ion binding Source: EcoCyc
  • UTP:glucose-1-phosphate uridylyltransferase activity Source: EcoCyc

GO - Biological processi

  • colanic acid biosynthetic process Source: EcoCyc
  • galactose catabolic process via UDP-galactose Source: EcoCyc
  • lipopolysaccharide core region biosynthetic process Source: EcoCyc
  • osmoregulated periplasmic glucan biosynthetic process Source: EcoCyc
  • protein homotetramerization Source: EcoCyc
  • UDP-glucose metabolic process Source: EcoCyc

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandMagnesium

Enzyme and pathway databases

BioCyciEcoCyc:GLUC1PURIDYLTRANS-MONOMER
MetaCyc:GLUC1PURIDYLTRANS-MONOMER
BRENDAi2.7.7.9 2026
SABIO-RKiP0AEP3

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galU
Synonyms:ychD
Ordered Locus Names:b1236, JW1224
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11319 galU

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002013542 – 302UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST301

Proteomic databases

EPDiP0AEP3
PaxDbiP0AEP3
PRIDEiP0AEP3

Interactioni

Subunit structurei

Homotetramer or homopentamer.

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4260121, 447 interactors
DIPiDIP-35950N
IntActiP0AEP3, 3 interactors
STRINGi316385.ECDH10B_1296

Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 14Combined sources5
Helixi20 – 22Combined sources3
Turni23 – 26Combined sources4
Beta strandi27 – 29Combined sources3
Helixi31 – 33Combined sources3
Helixi41 – 51Combined sources11
Beta strandi56 – 61Combined sources6
Helixi63 – 65Combined sources3
Helixi66 – 72Combined sources7
Helixi76 – 82Combined sources7
Helixi89 – 96Combined sources8
Beta strandi103 – 108Combined sources6
Helixi115 – 121Combined sources7
Helixi123 – 126Combined sources4
Beta strandi131 – 134Combined sources4
Beta strandi138 – 140Combined sources3
Turni147 – 149Combined sources3
Helixi152 – 162Combined sources11
Beta strandi165 – 171Combined sources7
Helixi175 – 177Combined sources3
Beta strandi178 – 182Combined sources5
Beta strandi193 – 196Combined sources4
Beta strandi198 – 202Combined sources5
Turni205 – 207Combined sources3
Beta strandi211 – 220Combined sources10
Helixi224 – 228Combined sources5
Helixi235 – 237Combined sources3
Helixi241 – 251Combined sources11
Beta strandi254 – 258Combined sources5
Beta strandi263 – 265Combined sources3
Helixi269 – 282Combined sources14
Turni284 – 286Combined sources3
Helixi287 – 297Combined sources11

3D structure databases

ProteinModelPortaliP0AEP3
SMRiP0AEP3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AEP3

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105C3Y Bacteria
COG1210 LUCA
HOGENOMiHOG000283477
InParanoidiP0AEP3
KOiK00963
OMAiKRYDVGN
PhylomeDBiP0AEP3

Family and domain databases

CDDicd02541 UGPase_prokaryotic, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR005771 GalU_uridylyltTrfase_bac/arc
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR43197 PTHR43197, 1 hit
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR01099 galU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAINTKVKK AVIPVAGLGT RMLPATKAIP KEMLPLVDKP LIQYVVNECI
60 70 80 90 100
AAGITEIVLV THSSKNSIEN HFDTSFELEA MLEKRVKRQL LDEVQSICPP
110 120 130 140 150
HVTIMQVRQG LAKGLGHAVL CAHPVVGDEP VAVILPDVIL DEYESDLSQD
160 170 180 190 200
NLAEMIRRFD ETGHSQIMVE PVADVTAYGV VDCKGVELAP GESVPMVGVV
210 220 230 240 250
EKPKADVAPS NLAIVGRYVL SADIWPLLAK TPPGAGDEIQ LTDAIDMLIE
260 270 280 290 300
KETVEAYHMK GKSHDCGNKL GYMQAFVEYG IRHNTLGTEF KAWLEEEMGI

KK
Length:302
Mass (Da):32,942
Last modified:January 23, 2007 - v2
Checksum:iADEAEB3F6A1194CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59940 Genomic DNA Translation: CAA42564.1
M98830 Unassigned DNA Translation: AAA20118.1
U00096 Genomic DNA Translation: AAC74318.1
AP009048 Genomic DNA Translation: BAA36104.1
PIRiG64870 JC2265
RefSeqiNP_415752.1, NC_000913.3
WP_000718995.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74318; AAC74318; b1236
BAA36104; BAA36104; BAA36104
GeneIDi945730
KEGGiecj:JW1224
eco:b1236
PATRICifig|1411691.4.peg.1049

Similar proteinsi

Entry informationi

Entry nameiGALU_ECOLI
AccessioniPrimary (citable) accession number: P0AEP3
Secondary accession number(s): P25520
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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