galP

Functionⁱ

Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system).

GO - Molecular functionⁱ

carbohydrate:proton symporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
galactose:proton symporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 15558

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

galactose transmembrane transport
Source: EcoCyc
Inferred from direct assayⁱ
- 10830123

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Sugar transport, Symport, Transport

Biological process

Sugar transport, Symport, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:GALP-MONOMER MetaCyc:GALP-MONOMER

BioCycⁱ

EcoCyc:GALP-MONOMER
MetaCyc:GALP-MONOMER

Protein family/group databases

TCDBⁱ	2.A.1.1.1 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.1.1 the major facilitator superfamily (mfs)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Galactose-proton symporter Alternative name(s): Galactose transporter
Gene namesⁱ	Name:galP Ordered Locus Names:b2943, JW2910
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG12148 galP

EcoGeneⁱ

EG12148 galP

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
; Multi-pass membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 15	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	16 – 36	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	37 – 56	PeriplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	57 – 77	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	78 – 84	CytoplasmicSequence analysis	7
Transmembraneⁱ	85 – 105	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	106 – 112	PeriplasmicSequence analysis	7
Transmembraneⁱ	113 – 133	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	134 – 139	CytoplasmicSequence analysis	6
Transmembraneⁱ	140 – 160	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	161 – 171	PeriplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	172 – 192	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	193 – 250	CytoplasmicSequence analysisAdd BLAST	58
Transmembraneⁱ	251 – 271	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	272 – 290	PeriplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	291 – 311	Helical; Name=8Sequence analysisAdd BLAST	21
Topological domainⁱ	312 – 321	CytoplasmicSequence analysis	10
Transmembraneⁱ	322 – 342	Helical; Name=9Sequence analysisAdd BLAST	21
Topological domainⁱ	343 – 351	PeriplasmicSequence analysis	9
Transmembraneⁱ	352 – 372	Helical; Name=10Sequence analysisAdd BLAST	21
Topological domainⁱ	373 – 394	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	395 – 415	Helical; Name=11Sequence analysisAdd BLAST	21
Topological domainⁱ	416	PeriplasmicSequence analysis	1
Transmembraneⁱ	417 – 437	Helical; Name=12Sequence analysisAdd BLAST	21
Topological domainⁱ	438 – 464	CytoplasmicSequence analysisAdd BLAST	27

GO - Cellular componentⁱ

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050292	1 – 464	Galactose-proton symporterAdd BLAST		464

Proteomic databases

PaxDbⁱ	P0AEP1
PRIDEⁱ	P0AEP1

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4260658, 17 interactors
STRINGⁱ	316407.85675753

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0AEP1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4107QNK Bacteria ENOG410XNQK LUCA
HOGENOMⁱ	HOG000202868
InParanoidⁱ	P0AEP1
KEGG Orthology (KO) More...KOⁱ	K08137
PhylomeDBⁱ	P0AEP1

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0AEP1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPDAKKQGRS NKAMTFFVCF LAALAGLLFG LDIGVIAGAL PFIADEFQIT 
        60         70         80         90        100
SHTQEWVVSS MMFGAAVGAV GSGWLSFKLG RKKSLMIGAI LFVAGSLFSA 
       110        120        130        140        150
AAPNVEVLIL SRVLLGLAVG VASYTAPLYL SEIAPEKIRG SMISMYQLMI 
       160        170        180        190        200
TIGILGAYLS DTAFSYTGAW RWMLGVIIIP AILLLIGVFF LPDSPRWFAA 
       210        220        230        240        250
KRRFVDAERV LLRLRDTSAE AKRELDEIRE SLQVKQSGWA LFKENSNFRR 
       260        270        280        290        300
AVFLGVLLQV MQQFTGMNVI MYYAPKIFEL AGYTNTTEQM WGTVIVGLTN 
       310        320        330        340        350
VLATFIAIGL VDRWGRKPTL TLGFLVMAAG MGVLGTMMHI GIHSPSAQYF 
       360        370        380        390        400
AIAMLLMFIV GFAMSAGPLI WVLCSEIQPL KGRDFGITCS TATNWIANMI 
       410        420        430        440        450
VGATFLTMLN TLGNANTFWV YAALNVLFIL LTLWLVPETK HVSLEHIERN 
       460 
LMKGRKLREI GAHD

Length:464

Mass (Da):50,983

Last modified:December 20, 2005 - v1

Checksum:ⁱ07E08935BD8E3F8E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28377 Genomic DNA Translation: AAA69110.1 U00096 Genomic DNA Translation: AAC75980.1 AP009048 Genomic DNA Translation: BAE77006.1
PIRⁱ	F65079
NCBI Reference Sequences More...RefSeqⁱ	NP_417418.1, NC_000913.3 WP_001112301.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75980; AAC75980; b2943 BAE77006; BAE77006; BAE77006
GeneIDⁱ	947434
KEGGⁱ	ecj:JW2910 eco:b2943
PATRICⁱ	fig\|1411691.4.peg.3790

Protein	Similar proteins		Species	Score	Length	Source
P0AEP1	Galactose-proton symporter		ECOL6		464	UniRef100_P0AEP2
Galactose-proton symporter		Escherichia coli O25b:H4-ST131		468
GalP		Escherichia coli O25b:H4		468
Galactose-proton symporter		Shigella dysenteriae WRSd3		468
Galactose-proton symporter		Shigella dysenteriae 1617		468
+186

Protein	Similar proteins		Species	Score	Length	Source
P0AEP1	Galactose-proton symporter		ECOL6		464	UniRef90_P0AEP2
Galactose-proton symporter		Escherichia coli O25b:H4-ST131		468
GalP		Escherichia coli O25b:H4		468
Galactose-proton symporter		Shigella dysenteriae WRSd3		468
Galactose-proton symporter		Shigella dysenteriae 1617		468
+1109

Protein	Similar proteins		Species	Score	Length	Source
P0AEP1	Galactose-proton symporter		ECOL6		464	UniRef50_P0AEP2
Galactose-proton symporter		Escherichia coli O25b:H4-ST131		468
GalP		Escherichia coli O25b:H4		468
Galactose-proton symporter		Shigella dysenteriae WRSd3		468
Galactose-proton symporter		Shigella dysenteriae 1617		468
+1604

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28377 Genomic DNA Translation: AAA69110.1 U00096 Genomic DNA Translation: AAC75980.1 AP009048 Genomic DNA Translation: BAE77006.1
PIRⁱ	F65079
RefSeqⁱ	NP_417418.1, NC_000913.3 WP_001112301.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P0AEP1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260658, 17 interactors
STRINGⁱ	316407.85675753

Protein family/group databases

TCDBⁱ	2.A.1.1.1 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.1.1 the major facilitator superfamily (mfs)

Proteomic databases

PaxDbⁱ	P0AEP1
PRIDEⁱ	P0AEP1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75980; AAC75980; b2943 BAE77006; BAE77006; BAE77006
GeneIDⁱ	947434
KEGGⁱ	ecj:JW2910 eco:b2943
PATRICⁱ	fig\|1411691.4.peg.3790

Organism-specific databases

EchoBASEⁱ	EB2068
EcoGeneⁱ	EG12148 galP

Phylogenomic databases

eggNOGⁱ	ENOG4107QNK Bacteria ENOG410XNQK LUCA
HOGENOMⁱ	HOG000202868
InParanoidⁱ	P0AEP1
KOⁱ	K08137
PhylomeDBⁱ	P0AEP1

Enzyme and pathway databases

BioCycⁱ	EcoCyc:GALP-MONOMER MetaCyc:GALP-MONOMER

BioCycⁱ

EcoCyc:GALP-MONOMER
MetaCyc:GALP-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0AEP1

PROⁱ

PR:P0AEP1

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GALP_ECOLI
Accessionⁱ	P0AEP1Primary (citable) accession number: P0AEP1 Secondary accession number(s): P37021, Q2M9Q0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	December 20, 2005
	Last modified:	November 7, 2018
	This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0AEP1 (GALP_ECOLI)

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Galactose-proton symporter

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ