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Protein

Galactose-proton symporter

Gene

galP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system).

GO - Molecular functioni

  • carbohydrate:proton symporter activity Source: GO_Central
  • galactose:proton symporter activity Source: EcoCyc

GO - Biological processi

Keywordsi

Biological processSugar transport, Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GALP-MONOMER
MetaCyc:GALP-MONOMER

Protein family/group databases

TCDBi2.A.1.1.1 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-proton symporter
Alternative name(s):
Galactose transporter
Gene namesi
Name:galP
Ordered Locus Names:b2943, JW2910
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12148 galP

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini37 – 56PeriplasmicSequence analysisAdd BLAST20
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 84CytoplasmicSequence analysis7
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 112PeriplasmicSequence analysis7
Transmembranei113 – 133Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini134 – 139CytoplasmicSequence analysis6
Transmembranei140 – 160Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini161 – 171PeriplasmicSequence analysisAdd BLAST11
Transmembranei172 – 192Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini193 – 250CytoplasmicSequence analysisAdd BLAST58
Transmembranei251 – 271Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini272 – 290PeriplasmicSequence analysisAdd BLAST19
Transmembranei291 – 311Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini312 – 321CytoplasmicSequence analysis10
Transmembranei322 – 342Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini343 – 351PeriplasmicSequence analysis9
Transmembranei352 – 372Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini373 – 394CytoplasmicSequence analysisAdd BLAST22
Transmembranei395 – 415Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini416PeriplasmicSequence analysis1
Transmembranei417 – 437Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini438 – 464CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502921 – 464Galactose-proton symporterAdd BLAST464

Proteomic databases

PaxDbiP0AEP1
PRIDEiP0AEP1

Interactioni

Protein-protein interaction databases

BioGridi4260658, 17 interactors
STRINGi316407.85675753

Structurei

3D structure databases

ProteinModelPortaliP0AEP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QNK Bacteria
ENOG410XNQK LUCA
HOGENOMiHOG000202868
InParanoidiP0AEP1
KOiK08137
PhylomeDBiP0AEP1

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDAKKQGRS NKAMTFFVCF LAALAGLLFG LDIGVIAGAL PFIADEFQIT
60 70 80 90 100
SHTQEWVVSS MMFGAAVGAV GSGWLSFKLG RKKSLMIGAI LFVAGSLFSA
110 120 130 140 150
AAPNVEVLIL SRVLLGLAVG VASYTAPLYL SEIAPEKIRG SMISMYQLMI
160 170 180 190 200
TIGILGAYLS DTAFSYTGAW RWMLGVIIIP AILLLIGVFF LPDSPRWFAA
210 220 230 240 250
KRRFVDAERV LLRLRDTSAE AKRELDEIRE SLQVKQSGWA LFKENSNFRR
260 270 280 290 300
AVFLGVLLQV MQQFTGMNVI MYYAPKIFEL AGYTNTTEQM WGTVIVGLTN
310 320 330 340 350
VLATFIAIGL VDRWGRKPTL TLGFLVMAAG MGVLGTMMHI GIHSPSAQYF
360 370 380 390 400
AIAMLLMFIV GFAMSAGPLI WVLCSEIQPL KGRDFGITCS TATNWIANMI
410 420 430 440 450
VGATFLTMLN TLGNANTFWV YAALNVLFIL LTLWLVPETK HVSLEHIERN
460
LMKGRKLREI GAHD
Length:464
Mass (Da):50,983
Last modified:December 20, 2005 - v1
Checksum:i07E08935BD8E3F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69110.1
U00096 Genomic DNA Translation: AAC75980.1
AP009048 Genomic DNA Translation: BAE77006.1
PIRiF65079
RefSeqiNP_417418.1, NC_000913.3
WP_001112301.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75980; AAC75980; b2943
BAE77006; BAE77006; BAE77006
GeneIDi947434
KEGGiecj:JW2910
eco:b2943
PATRICifig|1411691.4.peg.3790

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69110.1
U00096 Genomic DNA Translation: AAC75980.1
AP009048 Genomic DNA Translation: BAE77006.1
PIRiF65079
RefSeqiNP_417418.1, NC_000913.3
WP_001112301.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP0AEP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260658, 17 interactors
STRINGi316407.85675753

Protein family/group databases

TCDBi2.A.1.1.1 the major facilitator superfamily (mfs)

Proteomic databases

PaxDbiP0AEP1
PRIDEiP0AEP1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75980; AAC75980; b2943
BAE77006; BAE77006; BAE77006
GeneIDi947434
KEGGiecj:JW2910
eco:b2943
PATRICifig|1411691.4.peg.3790

Organism-specific databases

EchoBASEiEB2068
EcoGeneiEG12148 galP

Phylogenomic databases

eggNOGiENOG4107QNK Bacteria
ENOG410XNQK LUCA
HOGENOMiHOG000202868
InParanoidiP0AEP1
KOiK08137
PhylomeDBiP0AEP1

Enzyme and pathway databases

BioCyciEcoCyc:GALP-MONOMER
MetaCyc:GALP-MONOMER

Miscellaneous databases

PROiPR:P0AEP1

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGALP_ECOLI
AccessioniPrimary (citable) accession number: P0AEP1
Secondary accession number(s): P37021, Q2M9Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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