UniProtKB - P0AEP1 (GALP_ECOLI)
Protein
Galactose-proton symporter
Gene
galP
Organism
Escherichia coli (strain K12)
Status
Functioni
Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
GO - Molecular functioni
- galactose:proton symporter activity Source: EcoCyc
GO - Biological processi
- galactose transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Sugar transport, Symport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:GALP-MONOMER MetaCyc:GALP-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.1.1, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Galactose-proton symporterAlternative name(s): Galactose transporter |
Gene namesi | Name:galP Ordered Locus Names:b2943, JW2910 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 15 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 16 – 36 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 37 – 56 | PeriplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 57 – 77 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 84 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 85 – 105 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 106 – 112 | PeriplasmicSequence analysis | 7 | |
Transmembranei | 113 – 133 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 139 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 140 – 160 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 171 | PeriplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 172 – 192 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 193 – 250 | CytoplasmicSequence analysisAdd BLAST | 58 | |
Transmembranei | 251 – 271 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 272 – 290 | PeriplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 291 – 311 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 312 – 321 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 322 – 342 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 343 – 351 | PeriplasmicSequence analysis | 9 | |
Transmembranei | 352 – 372 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 373 – 394 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 395 – 415 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 416 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 417 – 437 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 438 – 464 | CytoplasmicSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050292 | 1 – 464 | Galactose-proton symporterAdd BLAST | 464 |
Proteomic databases
PaxDbi | P0AEP1 |
PRIDEi | P0AEP1 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260658, 17 interactors |
STRINGi | 511145.b2943 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_30_5_6 |
InParanoidi | P0AEP1 |
PhylomeDBi | P0AEP1 |
Family and domain databases
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0AEP1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPDAKKQGRS NKAMTFFVCF LAALAGLLFG LDIGVIAGAL PFIADEFQIT
60 70 80 90 100
SHTQEWVVSS MMFGAAVGAV GSGWLSFKLG RKKSLMIGAI LFVAGSLFSA
110 120 130 140 150
AAPNVEVLIL SRVLLGLAVG VASYTAPLYL SEIAPEKIRG SMISMYQLMI
160 170 180 190 200
TIGILGAYLS DTAFSYTGAW RWMLGVIIIP AILLLIGVFF LPDSPRWFAA
210 220 230 240 250
KRRFVDAERV LLRLRDTSAE AKRELDEIRE SLQVKQSGWA LFKENSNFRR
260 270 280 290 300
AVFLGVLLQV MQQFTGMNVI MYYAPKIFEL AGYTNTTEQM WGTVIVGLTN
310 320 330 340 350
VLATFIAIGL VDRWGRKPTL TLGFLVMAAG MGVLGTMMHI GIHSPSAQYF
360 370 380 390 400
AIAMLLMFIV GFAMSAGPLI WVLCSEIQPL KGRDFGITCS TATNWIANMI
410 420 430 440 450
VGATFLTMLN TLGNANTFWV YAALNVLFIL LTLWLVPETK HVSLEHIERN
460
LMKGRKLREI GAHD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69110.1 U00096 Genomic DNA Translation: AAC75980.1 AP009048 Genomic DNA Translation: BAE77006.1 |
PIRi | F65079 |
RefSeqi | NP_417418.1, NC_000913.3 WP_001112301.1, NZ_STEB01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC75980; AAC75980; b2943 BAE77006; BAE77006; BAE77006 |
GeneIDi | 58463733 947434 |
KEGGi | ecj:JW2910 eco:b2943 |
PATRICi | fig|1411691.4.peg.3790 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69110.1 U00096 Genomic DNA Translation: AAC75980.1 AP009048 Genomic DNA Translation: BAE77006.1 |
PIRi | F65079 |
RefSeqi | NP_417418.1, NC_000913.3 WP_001112301.1, NZ_STEB01000001.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260658, 17 interactors |
STRINGi | 511145.b2943 |
Protein family/group databases
TCDBi | 2.A.1.1.1, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P0AEP1 |
PRIDEi | P0AEP1 |
Genome annotation databases
EnsemblBacteriai | AAC75980; AAC75980; b2943 BAE77006; BAE77006; BAE77006 |
GeneIDi | 58463733 947434 |
KEGGi | ecj:JW2910 eco:b2943 |
PATRICi | fig|1411691.4.peg.3790 |
Organism-specific databases
EchoBASEi | EB2068 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_30_5_6 |
InParanoidi | P0AEP1 |
PhylomeDBi | P0AEP1 |
Enzyme and pathway databases
BioCyci | EcoCyc:GALP-MONOMER MetaCyc:GALP-MONOMER |
Miscellaneous databases
PROi | PR:P0AEP1 |
Family and domain databases
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GALP_ECOLI | |
Accessioni | P0AEP1Primary (citable) accession number: P0AEP1 Secondary accession number(s): P37021, Q2M9Q0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families